A5019528756- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Anesthesia and Neurotoxicity Research
- Topic Modeling
- Tissue Engineering and Regenerative Medicine
- Respiratory Support and Mechanisms
- Artificial Intelligence in Healthcare and Education
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Animal Genetics and Reproduction
- Renal and Vascular Pathologies
- Antibiotic Use and Resistance
- Virus-based gene therapy research
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Intensive Care Unit Cognitive Disorders
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Biomedical and Engineering Education
- 3D Printing in Biomedical Research
- Neuroethics, Human Enhancement, Biomedical Innovations
NYU Langone Health
2024-2025
New York University
2021-2025
Miami Transplant Institute
2024-2025
Columbia University Irving Medical Center
2023
Winterthur Museum Garden and Library
2023
Yale University
2023
University of Minnesota
2023
Washington University in St. Louis
2023
Angion (United States)
2023
University of Colorado System
2023
This manuscript aims to examine key scientific milestones leading human decedent studies and the compassionate use of cardiac xenografts in recipients. It also evaluates peri-operative considerations necessary before initiating large-scale clinical trials. The early functionality humans was initially demonstrated two brain-dead decedents through transplantation 10-gene-edited hearts from porcine donors. Subsequently, living patients received heart similarly constructed pigs. Although both...
ABSTRACT Introduction Some living organ donors will decide to donate again at a later date. Evidence has indicated that this practice may have increased in recent years. We evaluated the incidence and outcomes of inform counseling potential repeat donors. Methods Using SRTR data from 1994 2023, we identified 220 their 415 recipients. constructed donor comparison groups using weighting by odds. described clinical lab results 6 months, 1 year, 2 years post‐donation separately for kidney‐second...
Imlifidase is an IgG-cleaving endopeptidase conditionally approved in Europe for desensitization of highly sensitized patients before kidney transplantation. We present 5-y outcomes and donor-specific antibody (DSA) levels clinical trial participants from a single site who received imlifidase incompatible transplantation (NCT02790437). was administered up to 24 h living or deceased donor DSAs were monitored transplantation, at days 7 28, 5 y posttransplant. At y, 8 alive. One these had...
ABSTRACT Introduction Predicting graft failure risk in pediatric liver transplantation (LT) recipients could identify areas for improving management. Persistent cognitive, motor, academic, and functional deficits are common their impact on survival following LT helps inform prediction. Methods Using SRTR data 2008–2023, we evaluated the of at time transplant to 14 years post‐LT. We compared all cause (ACGF) among patients with versus without pre‐LT 1‐year post‐LT using Cox regression,...
Abstract Importance Large language models (LLMs) are crucial for medical tasks. Ensuring their reliability is vital to avoid false results. Our study assesses two state-of-the-art LLMs (ChatGPT and LlaMA-2) extracting clinical information, focusing on cognitive tests like MMSE CDR. Objective Evaluate ChatGPT LlaMA-2 performance in CDR scores, including associated dates. Methods data consisted of 135,307 notes (Jan 12th, 2010 May 24th, 2023) mentioning MMSE, CDR, or MoCA. After applying...
Ensuring reliability of Large Language Models (LLMs) in clinical tasks is crucial. Our study assesses two state-of-the-art LLMs (ChatGPT and LlaMA-2) for extracting information, focusing on cognitive tests like MMSE CDR. data consisted 135,307 notes (Jan 12th, 2010 to May 24th, 2023) mentioning MMSE, CDR, or MoCA. After applying inclusion criteria 34,465 remained, which 765 underwent ChatGPT (GPT-4) LlaMA-2, 22 experts reviewed the responses. successfully extracted CDR instances with dates...
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Abstract Introduction Thoracoabdominal normothermic regional perfusion (TA‐NRP) following cardiac death is an emerging multivisceral organ procurement technique. Recent national studies on outcomes of presumptive TA‐NRP‐procured organs are limited by potential misclassification since TA‐NRP not differentiated from donation after (DCD) in registry data. Methods We studied 22 donors whose designees consented to and performed at our institution between January 20, 2020 July 3, 2022. identified...
Registration of interventional trials Food and Drug Administration-regulated drug biological products devices became a legal requirement in 2007; the vast majority these are registered ClinicalTrials.gov. An analysis ClinicalTrials.gov offers an opportunity to define clinical research landscape; here we analyze 10 years infectious disease (ID) trial research.Beginning with 166 415 from 2007-2017, ID were selected by study conditions interventions. Relevance was confirmed through manual...