A5088199602- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Antibiotic Resistance in Bacteria
- Intensive Care Unit Cognitive Disorders
- COVID-19 diagnosis using AI
- Antibiotics Pharmacokinetics and Efficacy
- Hemodynamic Monitoring and Therapy
- Respiratory viral infections research
- Diabetes and associated disorders
- Pneumothorax, Barotrauma, Emphysema
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- interferon and immune responses
- Non-Invasive Vital Sign Monitoring
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Fernand-Widal
2020-2025
Hôpital Lariboisière
2016-2024
Université Paris Cité
2020-2024
Inserm
2019-2024
Aix-Marseille Université
2023-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2024
Hôpital Saint-Louis
2018-2024
Sorbonne Paris Cité
2024
Marqueurs cardiovasculaires en situation de stress
2023
Diagnosis of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) remains unclear especially in nonimmunocompromised patients. The aim this study was to evaluate seven mycological criteria and their combination a large homogenous cohort All successive patients (n = 176) hospitalized for COVID-19 requiring mechanical ventilation who clinically worsened despite appropriate standard care were included over 1-year period. Direct examination, culture, Aspergillus...
Ketamine, a nonbarbiturate general anaesthetic drug, has been proposed, off-label, as second-line agent for maintenance sedation of patients with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, including those Coronavirus infectious disease 2019 (COVID-19).1 Cholangiopathy is reported after chronic exposure to ketamine, in drug users and burned patients.2,3 We observed 5 COVID-19 from distinct tertiary centers (1 Germany, 4 France) cholangiopathy intravenous...
The SARS-CoV-2 pandemic is a worldwide challenge. CRIT-CoV-U pilot study generated urinary proteomic biomarker consisting of 50 peptides (COV50), which predicted death and disease progression from SARS-CoV-2. After the interim analysis presented for German Government, here, we aimed to analyse full dataset consolidate findings propose potential clinical applications this biomarker.CRIT-CoV-U was prospective multicentre cohort study. In eight European countries (Austria, France, Germany,...
Abstract Background Burns intensive care units (BICU) have reduced mortality in burns patients, but infections and sepsis remain the leading causes of death. Infections with multidrug-resistant (MDR) bacteria increase risk death whose acquiring such is higher due to various factors, including prolonged hospitalization invasive procedures. Methods A retrospective study was performed a French BICU over eight years, analyze epidemiology factors for bloodstream (BSI). Results In total, 1402...
Candida auris is a recently described emerging pathogen in hospital settings. Five genetic clades have been delineated, with each clade being isolated from specific geographic regions. We here describe the first transmission between 2 patients (P0 and P1) of I C. strain imported into our burn intensive care unit Middle East. The strains investigated whole-genome sequencing, which validated high similarity genomes isolates P0 P1. repeatedly screened two contact (i.e., other present same ward...
Abstract Importance Information about the severity of Omicron is scarce. Objective To report respective risk ICU admission in patients hospitalized with Delta and variants to compare characteristics disease critically ill infected both according vaccination status. Design Analysis from APHP database, called Reality, prospectively recording following information consecutive admitted for COVID-19: age, sex, immunosuppression, vaccination, pneumonia, need invasive mechanical ventilation, time...
Introduction Dipeptidyl peptidase-3 (DPP3) is a protease involved in the degradation of several cardiovascular mediators. Adrenomedullin (bio-ADM) peptide essential for regulation endothelial barrier function. In different shock-pathologies, both biomarkers are associated with disease severity, organ dysfunction and mortality. Associations outcome critically ill COVID-19 patients unknown. The objectives present study were to investigate associations bio-ADM “circulating DPP3” (cDPP3)...
Background/Objectives: Survival prospects following SARS-CoV-2 infection may extend beyond the acute phase, influenced by various factors including age, health conditions, and se-verity. However, this topic has not been studied in detail. We therefore investigated mortality risk post-acute COVID-19 CRIT-COV-U cohort. Methods: could retrieve survival data from 651 patients also assess association between urinary peptides future death. Data spanning until December 2023 were collected six...
ObjectivesThis study aimed to evaluate the performance of FilmArray Pneumonia Panel Plus (FA-PP) for detection typical bacterial pathogens in respiratory samples from patients hospitalized intensive care units (ICUs).MethodsFA-PP was implemented clinical use microbiology laboratory March 2020. A retrospective analysis on a consecutive cohort adult ICUs between 2020 and May undertaken. The included sputum, blind bronchoalveolar lavage (BBAL) protected specimen brush (PSB). Conventional...
Patients with extensive burns are at risk of developing candidemia.To identify potentially modifiable factors and outcomes candidemia in critically ill patients.Retrospective matched cohort study including adult patients. who developed were patients Candida spp colonisation sepsis or septic shock without a ratio 1:3 (same severity scores index). Univariate multiple regression analyses performed.Of 130 severely burned least one episode shock, 14 diagnosed candidemia. In the group, had median...