A5036837016- Transplantation: Methods and Outcomes
- Burn Injury Management and Outcomes
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- Central Venous Catheters and Hemodialysis
- Disaster Response and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Innovations in Medical Education
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Blood transfusion and management
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotic Use and Resistance
- Diversity and Career in Medicine
- Pneumothorax, Barotrauma, Emphysema
Hôpital Bichat-Claude-Bernard
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Inserm
2018-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Louis-Mourier
2023-2025
Centre de Recherche sur l'Inflammation
2018-2025
Centre National de la Recherche Scientifique
2018-2025
Hôpital Fernand-Widal
2025
Université Paris Cité
2015-2024
Sorbonne Paris Cité
2018-2024
Severe acute respiratory syndrome coronavirus2 has caused a global pandemic of coronavirus disease 2019 (COVID-19). High-density lipoproteins (HDLs), particles chiefly known for their reverse cholesterol transport function, also display pleiotropic properties, including anti-inflammatory or antioxidant functions. HDLs and low-density (LDLs) can neutralize lipopolysaccharides increase bacterial clearance. HDL (HDL-C) LDL (LDL-C) decrease during sepsis, an association been reported between low...
Abstract Background Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines but still misdiagnosed in elderly. The primary objective was compare all-cause mortality at day 30. Secondary objectives were clinical presentation and rates consolidative pneumonia, hospitalization, intensive care unit (ICU) admission. Methods A single-center retrospective study conducted a French university hospital during 7 epidemic seasons including 558 patients...
Deep sternal wound infection after cardiac surgery remains a serious complication associated with poor prognosis. is classified by the Centers for Disease Control and Prevention as deep incisional surgical site-infection mediastinitis. This study aims to describe incidence, perioperative characteristics, outcomes of on basis clinical presentations. monocentric retrospective included all consecutive patients who underwent cardiopulmonary bypass between 2006 2019 in tertiary teaching hospital....
Background High-density lipoproteins (HDLs) are synthesized by the liver and display endothelioprotective properties, including anti-inflammatory, antiapoptotic, antithrombotic antioxidant effects. In both septic chronic failure patients, a low HDL cholesterol (HDL-C) concentration is associated with overmortality. Whereas sepsis-associated dysfunction poorly defined, aim of this study was to characterize relationship between dysfunction, lipoprotein concentrations mortality in patients...
Abstract OBJECTIVES Following the reintroduction of aprotinin into European market, French Society Cardiovascular and Thoracic Anaesthesiologists recommended its prophylactic use at half-dose for high-risk cardiac surgery patients. We examined whether instead tranexamic acid could significantly reduce severe perioperative bleeding. METHODS This multicentre, retrospective, historical study included patients treated with or between December 2017 September 2020. The primary efficacy end point...
Abstract Background Burns intensive care units (BICU) have reduced mortality in burns patients, but infections and sepsis remain the leading causes of death. Infections with multidrug-resistant (MDR) bacteria increase risk death whose acquiring such is higher due to various factors, including prolonged hospitalization invasive procedures. Methods A retrospective study was performed a French BICU over eight years, analyze epidemiology factors for bloodstream (BSI). Results In total, 1402...
Metabolic disorders and fluid overload are indications of continuous renal replacement therapy (CRRT) including venovenous hemofiltration in patients on extracorporeal membrane oxygenation (ECMO). Direct connection CRRT machine to the ECMO circuit provides many advantages. Nevertheless, because pressures lines relate blood flow, high flow may be associated with lines. Thus, management pressure becomes challenging. We evaluated a protocol for managing pressures. Connections were performed...
Risk factors and the incidence of prolonged mechanical ventilation (PMV) after lung transplantation (LT) have been poorly described. The study assessed predictive PMV LT.This observational, retrospective, monocentric included all patients who received LT in Bichat Claude Bernard Hospital between January 2016 December 2020. was defined as a duration MV > 14 days. Independent risk for were studied using multivariate analysis. One-year survival depending on Kaplan Meier log-rank tests. A p...
Burn-induced shock can lead to tissue hypoperfusion, including the gut. We performed this study describe burn patients at risk of acute mesenteric ischemia (AMI) with aim identify potential modifiable factors.Retrospective case-control adult severely burned between August 2012 and March 2017. Patients who developed AMI were matched without a ratio 1:3 (same year admission, Abbreviated Burn Severity Index [ABSI], Simplified Acute Physiology Score II [SAPSII]). Univariate multiple regression...
Highlights•CD89 directly binds Streptococcus pneumoniae and Escherichia coli•CD89 acts as an innate receptor before adaptive responses take place•CD89 protects from sepsis by inducing immune against infectionsSummaryDirect bacterial recognition receptors is crucial for clearance. Here, we show that the IgA CD89 a major bacteria independently of its cognate ligands c-reactive protein (CRP). This binding only partially inhibited serum induces phagocytosis CD11c+ dendritic cells monocytes...
Abstract Background Prior studies have assessed the impact of pretransplantation recipient body mass index (BMI) on patient outcomes after lung transplantation (LT), but they not specifically addressed early postoperative complications. Moreover, donor BMI these complications has been evaluated. The first aim this study was to assess during hospitalization in ICU LT according and BMI. Methods All recipients who underwent at Bichat Claude Bernard Hospital, Paris, between January 2016 August...
Summary Background Characteristics and outcome of invasive fungal infection (IFI) in critically ill burn patients have been poorly explored. Objectives We report the factors associated with 90‐day mortality a multicentre retrospective European study. Patients/Methods All confirmed IFI admitted between 1 January 2010 to 31 December 2015 10 centres France Belgium were included. Results Ninety‐four enrolled 110 cases IFIs: 79 (71.8%) yeasts (28.2%) filamentous IFI. Incidence was 1% among...
Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently critically ill burn patients. The aim of this study was to assess the predictive value haptoglobin at admission predict major adverse events (MAKE) and AKI patients.We conducted a retrospective, single-centre cohort critical care unit tertiary centre, including all consecutive severely burned patients (total body...
The first aim of this study was to assess the association between stage 3 PGD and pre-donation blood transfusion donor. secondary objectives were epidemiology donor outcome LT recipients according status massive status. This an observational, prospective, single-center study. results are expressed as absolute numbers, percentages, medians, interquartile ranges. Statistical analyses performed using Chi squared, Fischer's exact tests, Mann-Whitney U tests (P < .05 considered significant). A...
(1) Background: Cephalosporins (CA) are the first-line antibiotic prophylaxis recommended to prevent surgical site infection (SSI) after cardiac surgery. The combination of vancomycin/gentamicin (VGA) might represent a good alternative, but few studies have evaluated its efficacy in SSI prevention. (2) Methods: A single-centre retrospective study was conducted over 13-year period all consecutive adult patients undergoing elective Patients were stratified according type prophylaxis. CA served...