A5060564696- Renal Diseases and Glomerulopathies
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Bioactive Compounds and Antitumor Agents
- Cytokine Signaling Pathways and Interactions
- Bariatric Surgery and Outcomes
- Immune Cell Function and Interaction
- Mast cells and histamine
- Protein Tyrosine Phosphatases
- Diet and metabolism studies
- Inflammation biomarkers and pathways
- Systemic Lupus Erythematosus Research
- Phagocytosis and Immune Regulation
- Body Contouring and Surgery
- Immune Response and Inflammation
- Complement system in diseases
Inserm
2016-2024
Université Paris Cité
2019-2024
Centre de Recherche sur l'Inflammation
2017-2024
Centre National de la Recherche Scientifique
2019-2024
Délégation Paris 7
2019-2021
Sorbonne Paris Cité
2019-2021
Nutrition et obésité : approches systémiques
2016
Sorbonne Université
2016
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that deposited kidneys, leading to glomerulonephritis. In intestinal microbiota patients with IgA nephropathy, there was increased relative abundance mucin-degrading bacteria, including Akkermansia muciniphila . A. both...
Immunoreceptors can transduce either inhibitory or activatory signals depending on ligand avidity and phosphorylation status, which is modulated by the protein kinases Lyn Fyn. Here we show that Fyn control immune receptor signaling status. SHP-1 tyrosine 536 activates phosphatase promoting through immunoreceptor. By contrast, Fyn-dependent of serine 591 inactivates phosphatase, enabling immunoreceptor signaling. These signatures are relevant in vivo, as deficiency exacerbates nephritis...
Background The number of morbidly obese patients undergoing bariatric surgery (BS) has increased dramatically in recent years. Therefore, monitoring food intake and its consequences terms nutritional status is necessary to prevent deficiencies. aim this study was analyze the effect restriction on parameters short-term (≤3 months) period after BS morbid obesity. Method In a prospective study, we followed 22 women who underwent Roux-en-Y gastric bypass (GBP) or adjustable banding (AGB) at...
IgA Nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by mesangial deposition of abnormally glycosylated IgA1 (Gd-IgA). The production Gd-IgA occurs in mucose-associated lymphoid tissue (MALT). microbiota plays a role MALT modulation. Rifaximin (NORMIX
Highlights•CD89 directly binds Streptococcus pneumoniae and Escherichia coli•CD89 acts as an innate receptor before adaptive responses take place•CD89 protects from sepsis by inducing immune against infectionsSummaryDirect bacterial recognition receptors is crucial for clearance. Here, we show that the IgA CD89 a major bacteria independently of its cognate ligands c-reactive protein (CRP). This binding only partially inhibited serum induces phagocytosis CD11c+ dendritic cells monocytes...
Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease in which circulating immune complexes can cause different types of glomerulonephritis, according to deposits and the type glomerular cell injury. Proliferative lesions represent most severe form nephritis (LN) often lead kidney failure death. Mucosal-associated invariant T (MAIT) cells are a subset innate-like that recognize microbial-derived ligands from riboflavin synthesis pathway. Although abundant peripheral blood,...