A5052505511- Cancer, Hypoxia, and Metabolism
- Toxin Mechanisms and Immunotoxins
- RNA Interference and Gene Delivery
- Neuroblastoma Research and Treatments
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Lipid Membrane Structure and Behavior
- Cancer Cells and Metastasis
- Immune responses and vaccinations
- Inflammation biomarkers and pathways
- Phytochemical compounds biological activities
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Signaling Pathways in Disease
Hospital Universitario Reina Sofía
2014-2024
University of Córdoba
2014-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2014-2024
Université Paris Cité
2019
Centre National de la Recherche Scientifique
2019
Centre de Recherche sur l'Inflammation
2019
Inserm
2019
Délégation Paris 7
2019
Sorbonne Paris Cité
2019
Institute for Research in Biomedicine
2014
Highlights•CD89 directly binds Streptococcus pneumoniae and Escherichia coli•CD89 acts as an innate receptor before adaptive responses take place•CD89 protects from sepsis by inducing immune against infectionsSummaryDirect bacterial recognition receptors is crucial for clearance. Here, we show that the IgA CD89 a major bacteria independently of its cognate ligands c-reactive protein (CRP). This binding only partially inhibited serum induces phagocytosis CD11c+ dendritic cells monocytes...
Lung cancer is the leading cause of cancer-related deaths worldwide. Overall 5-year survival has shown little improvement over last decades. Seven in absentia homolog (SIAH) proteins are E3 ubiquitin ligases that mediate proteasomal protein degradation by poly-ubiquitination. Even though SIAH play a key role several biological processes, their human remains controversial. The aim study was to document SIAH2 expression pattern at different levels (mRNA, level and immunohistochemistry)...
Metastasis is the leading cause of cancer mortality. Metastatic notoriously difficult to treat, and it accounts for majority cancer-related deaths. The ether lipid edelfosine prototype a family synthetic antitumor compounds collectively known as alkylphospholipid analogs, its activity involves raft reorganization. In this study, we examined effect on metastatic colonization angiogenesis. Using non-invasive bioluminescence imaging histological examination, found that oral administration in...