A5016555269- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Botulinum Toxin and Related Neurological Disorders
- Myasthenia Gravis and Thymoma
- Genetic Neurodegenerative Diseases
- Autoimmune Neurological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Dysphagia Assessment and Management
- Amyotrophic Lateral Sclerosis Research
- Muscle activation and electromyography studies
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
- Voice and Speech Disorders
- Child Nutrition and Feeding Issues
- Neurological and metabolic disorders
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Eosinophilic Esophagitis
- Trigeminal Neuralgia and Treatments
- Nerve injury and regeneration
- Cerebrovascular and genetic disorders
Wroclaw Medical University
2015-2024
University of Curaçao
2021-2023
Szpital Kliniczny Nr 1 we Wrocławiu
2022
Neurology, Inc
2013-2021
Maastricht University
2021
University of Wrocław
2009-2019
Niepubliczna Wyższa Szkoła Medyczna
1999-2008
Alpha-synucleinopathy constituting a characteristic feature of Parkinson's disease (PD) occurs at all levels the brain-gut axis including enteric nervous system (ENS). Lesions in ENS may be connected with gut inflammation, increased intestinal permeability and dysmotility contributing to pathogenesis PD its gastrointestinal manifestations. To evaluate fecal calprotectin zonulin as biomarkers inflammation barrier dysfunction patients. Quantitative evaluation was performed by ELISA tests 35...
Abstract Background: Based on Davis's law, greater tonus of the muscle belly in individuals with Parkinson's disease can create tension tendon, leading to structural adjustment and an increase tendon stiffness. Our study aimed separately assess passive stiffness medicated patients disease, using myotonometry. Methods: We tested 12 healthy matched controls. Passive was estimated by myotonometry, electromyography, mechanomyography relaxed biceps triceps brachii muscles. Results: Compared...
Background: This study examined the generalized effects of cycle ergometer aerobic interval training (AIT) on psychomotor behaviors in individuals with Parkinson’s disease (PD), including bimanual motor control, cognitive function, and neurological non-motor parkinsonian signs. Methods: Twenty mild to moderate PD patients were randomly allocated following groups: (1) trained group (PD-TR, n = 10), which besides receiving usual care, underwent an 8-week intensity AIT program; or (2) control...
Abstract Background Spinal adhesive arachnoiditis is a chronic inflammatory process of the leptomeninges and intrathecal neural elements. The possible causes are: infections, injuries spinal cord, surgical procedures administration therapeutic substances or contrast. Case presentation We present case 56-old woman with muscular atrophy type 3 who developed severe back pain in lumbosacral region after fifth dose nusinersen given intrathecally. Magnetic resonance spine showed arachnoiditis. She...
Abstract Intravenous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy usually starts with a 2.0 g/kg induction dose followed by 1.0 maintenance doses every 3 weeks. No dose-ranging studies intravenous therapy have been published. The Progress in Chronic Inflammatory Demyelinating (ProCID) study was prospective, double-blind, randomized, parallel-group, multicentre, phase III investigating the efficacy and safety of 10% liquid (Panzyga®) patients active...
Holmes tremor (HT) is a combination of rest, postural and action tremor. A parallel dysfunction cerebello-thalamic nigrostriatal pathways seems necessary to produce this kind We present the clinical neuroimaging study verifying that hypothesis.A total 10 patients: five male, female, fulfilling consensus criteria were included. Demographic, data (MRI = 9; CT 1, SPECT with use 123-I-FP CIT: DaTSCAN in six patients assess presynaptic dopaminergic system involvement, indices asymmetry for ligand...
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate association CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with levels membrane (mCTLA-4) cytoplasmic (cCTLA-4) CD4(+) T lymphocytes from patients multiple sclerosis (MS) susceptibility MS, course disease. It found that Jo31GG CT60GG genotypes were associated decreased mean fluorescence intensity (MFI) total (mCTLA-4 +...
Abstract Background Chronic exposure to heavy metals affects various organs, among them the brain and peripheral nerves. Polyneuropathy is mainly length-dependent with predominantly sensory symptoms. There have been few studies on small fiber neuropathy due metal intoxication. Methods We investigated 41 industry workers, mean age 51.3 ± 10.5 years, at least 5 years’ professional metals, 36 age- sex-matched healthy controls. performed neurological examinations, assessed blood levels of...
Diabetic sensorimotor polyneuropathy is an important risk factor for foot ulceration and amputation. Thus, patients with diabetes should be screened this disorder according to local guidelines. An obstacle the diagnosis of disease may lack unified diagnostic criteria due properly validated scales used assessment.To validate both sections (A B) Michigan Neuropathy Screening Instrument (MNSI) in Polish (PL) diabetes.A cross-sectional study using a test (A1, B1) re-test (A2, B2) formula was...
Background. MicroRNAs are endogenous, small noncoding RNA molecules that play a pivotal role in the regulation of gene expression. involved many biological processes such as proliferation, cell differentiation, neovascularization, and apoptosis. Studies on microRNA expression may contribute to better understanding pathomechanism chronic inflammatory demyelinating polyneuropathy (CIDP) consequently enable development new therapeutic measures using antisense miRNAs (antagomirs). In this study,...
Diagnosis of amyotrophic lateral sclerosis (ALS) is based on clinical criteria and electrophysiological tests (electromyography, transcranial magnetic stimulation). In the search for ALS biomarkers, role imaging procedures currently emphasized, especially modern MR techniques. were performed 15 patients a sex- age-matched control group. The examinations with 1.5-T unit, protocol consisted sagittal T1-weighed images, axial T2-weighed FAT SAT images followed by an diffusion tensor (DTI)...
Parry-Romberg syndrome (PRS) is a rare disorder, described in the nineteenth century by Caleb Parry and Moritz Romberg, characterized acquired slowly progressive atrophy of one side face. The pathogenesis PRS still unclear. Immune-mediated processes are thought to be basic factor etiology, but autonomic nervous system might also impaired. A case 26-year-old woman with coexisting disturbances lower left limb presented. multimodal electrophysiological studies were done, including...
Holmes's tremor (HT) is assumed to be the result of coexistence nigrostriatal dopaminergic system impairment and lesion cerebello-thalamic pathways. It was suggested that deficiency responsible for rest tremor, lack compensatory cerebellar function leads spill into voluntary movements. Cases HT with without abnormalities presynaptic part were published these findings raised question possibility postsynaptic lesion. Three patients diagnosed according criteria Consensus Statement on Tremor...
Objective The current research aimed to analyze the alterations within motor cortex and pyramidal pathways their association with degree of damage peripheral nerve fibers in patients chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). To achieve that goal, we investigated microstructural changes white matter tracts using diffusion tensor imaging (DTI) parameters, evaluated metabolic both precentral gyri magnetic resonance spectroscopy (MRS) ratios, correlated them neurographic...
: Spinal muscular atrophy (SMA) is a genetically determined disease primarily leading to muscle weakness, but now, it considered systemic with changes in various tissues and organs. In our study, we aimed compare quality of life (QoL) outcomes patients SMA relation the degree motor limitation comorbidities, mainly internal medicine diseases.
Background. Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Malnutrition an essential problem in late stage PD. Lowering body mass seen 30% patients, and malnutrition or risk 24% 60%, respectively.Objectives. The aim study was analysis relationships between parameters nutritional advancement clinical symptoms PD patients.Material Methods. A total 40 patients (18 men, 22 women) with were analyzed, mean age: 70.7 years. In all structured anamnesis, Nutrition...