A5103245126- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Tumors and Oncological Cases
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
- Chromatin Remodeling and Cancer
- Occupational and environmental lung diseases
- Renal and related cancers
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Plant tissue culture and regeneration
- Soft tissue tumor case studies
- Advanced Clustering Algorithms Research
- Technology and Security Systems
- Musculoskeletal synovial abnormalities and treatments
- Metastasis and carcinoma case studies
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Uterine Myomas and Treatments
Hebei Agricultural University
2023-2025
Oil Crops Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Qingdao University of Science and Technology
2005-2021
National Cancer Institute
2012-2019
Center for Cancer Research
2013-2019
National Institutes of Health
2016-2019
Shenzhen Sixth People's Hospital
2014
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013
GATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia, and subsets T lymphocytes. It has been suggested to be useful evaluation carcinomas mammary or urothelial origin metastatic carcinomas, but its distribution normal neoplastic tissues incompletely mapped. In this study, we examined developing adult 2040 epithelial 460 mesenchymal neuroectodermal neoplasms for expression explore diagnostic value surgical pathology, using monoclonal antibody (clone...
Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduction kinases such as KIT, or, alternatively, manifest loss-of-function defects in the mitochondrial succinate dehydrogenase (SDH) complex, a component Krebs cycle and electron transport chain. We have uncovered striking divergence between DNA methylation profiles SDH-deficient GIST (n = 24) versus KIT tyrosine kinase pathway-mutated 39). Infinium 450K array analysis formalin-fixed paraffin-embedded tissues...
Sox10 transcription factor is expressed in schwannian and melanocytic lineages important their development can be used as a marker for corresponding tumors. In addition, it has been reported subsets of myoepithelial/basal cell epithelial neoplasms, but its expression remains incompletely characterized. this study, we examined 5134 human neoplasms spanning wide spectrum neuroectodermal, mesenchymal, lymphoid, A new rabbit monoclonal antibody (clone EP268) Leica Bond Max automation were on...
The SALL4 transcription factor is associated with embryonic cell pluripotency and has been shown as a useful immunohistochemical marker for germ tumors. However, information of distribution in normal human tissues non-germ tumors limited. In this study we examined 3215 expression using monoclonal antibody 6E3 automated immunohistochemistry. 10-week embryo, was expressed ovocytes, intestine, kidney, some hepatocytes. adult tissues, it only detected cells. consistently all except trophoblastic...
Methylation of the SDH gene explains loss expression in wild-type gastrointestinal stromal tumors.
Brachyury is a transcription factor of the T-box family typically expressed in notochord and chordoma. Some studies report brachyury as highly specific for chordoma, whereas others have concluded that many types common carcinomas by reverse polymerase chain reaction immunohistochemistry could be involved epithelial-mesenchymal transition metastatic process. In this study, we immunohistochemically evaluated 5229 different tumors nuclear expression using new rabbit monoclonal antibody...
ERG transcription factor is constitutively expressed in endothelial cells. Because benign and malignant vascular endothelia retain the expression, considered a useful marker for angiosarcomas related tumors. also subset of prostate carcinomas Ewing sarcomas due to ERG-involved translocations; therefore, this high interest study these malignancies. In study, we evaluated 109 epithelioid on basis an initial observation ERG-positive case. We studied expression other antigens sarcoma. was 38%...
Programmed cell death 1/programmed ligand (PD-1/PD-Ls) axis is crucial for the modulation of immune responses and self-tolerance. Also, aberrant PD-L1 expression on tumor cells or tumor-associated inflammatory accelerates evasion cells. In past decade, PD-1/PD-L checkpoint inhibitors were introduced to cancer treatment trials and, in some cases, showed significant anticancer effects. immunohistochemical staining considered a potential predictor clinical response inhibitor treatment. However,...
Loss-of-function germline mutations in the fumarase (FH) gene of Krebs cycle characterize hereditary leiomyomatosis and renal cell cancer syndrome. Fumarase deficiency can be diagnosed by loss immunohistochemical expression. In this study, we investigated occurrence clinicopathologic features FH-deficient uterine smooth muscle tumors (SMTs). A total 1583 157 nonuterine SMTs were examined using a polyclonal FH antibody automated immunohistochemistry, 86 leiomyomas with an identified. The...
Smyd1b is a member of the Smyd family that specifically expressed in skeletal and cardiac muscles. plays key role thick filament assembly during myofibrillogenesis muscles zebrafish embryos. To better characterize function its mechanism action myofibrillogenesis, we analyzed effects smyd1b knockdown on The results show causes significant disruption myofibril organization both Microarray quantitative reverse transcription-PCR analyses up-regulates heat shock protein 90 (hsp90) unc45b gene...
A majority of gastrointestinal stromal tumors (GISTs) carry gain-of-function KIT or platelet-derived growth factor receptor α (PDGFRA) mutations. However, no mutational activation PDGFRA has been identified in pediatric gastric GISTs, neurofibromatosis-1-associated and a small subset sporadic GISTs adults [so-called wild-type (WT) GISTs]. Recently, some adult WT have found to losses the succinate dehydrogenase (SDH) complex, Krebs cycle/electron transport chain interface protein, as seen by...
Tumors of the central nervous system are second most common malignancy in children. In particular, diffuse intrinsic pontine gliomas (DIPGs) aggressive tumors with poor prognosis and account for 10% to 25% pediatric brain tumors. The majority DIPGs astrocytic, infiltrative, localized pons. Studies have shown median survival times less than a year, 90% children dying within 2 years. We built multitissue arrays 24 postmortem DIPG samples analyzed morphology expression several proteins (p53,...
// Shingo Inaguma 1, 2 , Zengfeng Wang 1 Jerzy Lasota Masanori Onda 3 Piotr Czapiewski 4, 5 Renata Langfort 6 Janusz Rys 7 Joanna Szpor 8 Waloszczyk 9 Krzysztof Okoń Wojciech Biernat 4 Hiroshi Ikeda David S. Schrump 10 Raffit Hassan Ira Pastan Markku Miettinen Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA Department Aichi Medical University School Medicine, Nagakute, Japan Molecular Biology, Pathomorphology, Gdansk, Poland Otto-von-Guericke Magdeburg, Germany...
Germplasm resources with rich genetic diversities are indispensable, but often fail short to need the demand for crop breeding (Snowdon et al., 2015). Genomic introgression in hybrids of closely related species is considered be an important source diversity enhancement, which mainly through homoeologous exchanges (HEs) among chromosomes (Zhou 2021). However, technical bottleneck terms low frequency genome segments interspecific hybrid offspring (Quezada-Martinez 2021), has not been solved,...
Most gastrointestinal stromal tumors (GISTs) occur in the tubular (GI) tract, but some present apparently outside GI tract. In this study, we analyzed 112 GISTs located retroperitoneum. These occurred 55 women and 57 men with a median age of 65 years (range: 21 to 89 y). On basis clinically or histologically detected connections 15 were considered likely gastric, 9 duodenal, 13 small intestinal origin. The remaining cases categorized by location as peripancreatic (n=25), pelvic (n=11),...
Losses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% 8% gastric GISTs, rare renal cell carcinomas. This loss is reflected as lack normally ubiquitous immunohistochemical expression SDH subunit B (SDHB). In paragangliomas, SDHB correlates with homozygous any subunits, typically by loss-of-function mutations. The occurrence losses other epithelial malignancies unknown. this study, we immunohistochemically examined 2258 epithelial,...
Calretinin is an intracellular calcium-binding EF-hand protein of the calmodulin superfamily. It plays a role in diverse cellular functions, including message targeting and calcium signaling. expressed mesothelium, mast cells, some neural fat among others. Because its relative specificity for mesothelial neoplasms, calretinin widely used as one primary immunohistochemical markers malignant mesothelioma differentiating it from adenocarcinoma. On basis our sporadic observation on...
// Shingo Inaguma 1, 2 , Zengfeng Wang 1 Jerzy P. Lasota Markku M. Miettinen Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA Department Aichi Medical University School Medicine, Nagakute, Japan Correspondence to: Inaguma, email: inaguma@aichi-med-u.ac.jp Keywords: CD171 (NCAM-L1, L1CAM), immunohistochemistry, neuroectodermal tumor, gastrointestinal stromal mismatch repair deficiency Received: February 10, 2016 Accepted: May 26, Published: July 11, ABSTRACT The neural...
Aberrant PD-L1 (CD274) expression has been described in different types of tumour and linked to aggressiveness a poor prognosis. In primary colorectal carcinomas (CRCs), CD274 was reported be associated with mismatch repair (MMR)-deficiency, BRAF mutation, "stem-like" immunophenotype defined by down-regulation homeobox protein CDX2 membranous activated leukocyte cell adhesion molecule (ALCAM). However, the genotype CD274-positive metastatic CRC have not extensively analysed. this study, 189...
Advantages of None Euclidean Relational Fuzzy C-means (NERFCM) is analysed, by which four (FCM) clustering algorithms are compared, includes and traditional (RFCM) Any (ARFCM). Their common points different limitations on usage discussed, finally an optimal algorithm chosen its application human posture classification implemented, experiments prove efficiency sensitivity.
Marginal zone lymphoma (MZL) and mantle cell (MCL) belong to a subgroup of indolent B-cell lymphomas most commonly reported in the canine spleen. The goal this study was characterize immunophenotype splenic MZL MCL comparison their human counterparts. Ten MCLs 28 MZLs were selected based on morphology. A tissue microarray generated, expression CD3, CD5, CD10, CD45, CD20, CD79a, Pax-5, Bcl-2, Bcl-6, cyclin D1, D3, MCL-1, MUM-1, Sox-11 evaluated. Neoplastic cells all positive for BCL2 negative...