A5070427250- Hepatitis C virus research
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pneumonia and Respiratory Infections
- Childhood Cancer Survivors' Quality of Life
- Microscopic Colitis
- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
- Folate and B Vitamins Research
- DNA Repair Mechanisms
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Cardiovascular Syncope and Autonomic Disorders
- Bacterial Identification and Susceptibility Testing
- Plant Genetic and Mutation Studies
- Nutrition and Health Studies
- Pediatric health and respiratory diseases
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- Tissue Engineering and Regenerative Medicine
- Intramuscular injections and effects
- Hepatitis Viruses Studies and Epidemiology
Institute of Human Genetics
2014-2022
Polish Academy of Sciences
2014-2022
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2022
University of North Carolina at Chapel Hill
2020
Antoni Jurasz University Hospital
2016
The aim was to analyse TLR2 rs5743708, rs4696480, TLR4 rs4986790, TLR9 rs5743836, and rs352140 single nucleotide polymorphisms (SNPs) in children with pneumococcal meningococcal meningitis their family members.The study group consisted of 39 bacterial (25 14 meningitis) 49 members. Laboratory test results the course diseases were analyzed. Genomic DNA extracted from 1.2ml peripheral blood order analyze five SNPs.Patients showed a similar male/female ratio, mean age, duration symptoms. There...
The etiology of acute lymphoblastic leukemia (ALL) is complex, linked with both environmental exposures and genetic factors. Functional variants the methylenetetrahydrofolate reductase (MTHFR) gene result in disturbance folate metabolism may affect susceptibility to cancer. study was performed evaluate whether MTHFR C677T A1298C polymorphisms, analyzed separately together, are associated development ALL a population under 18 years age Caucasian ancestry. included 117 pediatric patients (59%...
To evaluate the association of IFNL3 (IL28B) SNP rs4803217 with severity disease and treatment outcome in chronic hepatitis C (CHC).The study enrolled 196 CHC Polish patients (82 women 114 men age 20-64) infected virus (HCV) genotype 1. They were naïve qualified to pegylated interferon alpha (PEG-IFN-α) ribavirin (RBV) therapy. The analyzed baseline parameters included: degree inflammation, stage fibrosis, viral load as well alanine aminotransferase (ALT), asparagine (AST) total bilirubin...
Vaccination effectiveness is proven when the disease does not develop after a patient exposed to pathogen. In case of rare diseases, vaccination assessed by monitoring specific antibody levels in population. Such recurrent analyses allow evaluation programs. The primary schedule diphtheria and tetanus vaccinations similar various countries, with differences mainly number timing booster doses. aim study was assess concentrations population healthy children. Diphtheria were analyzed group 324...
Background Cancer survival rates and longevity of patients after therapy have significantly improved during the last decades. Thus durable protection against infections should be provided. The aim study was to compare levels vaccine-derived antibodies in children with cancer compared those healthy investigate how influences specific antibodies. Procedure A group 40 children, diagnosed acute lymphoblastic leukemia (ALL) or solid tumor (ST), followed Poznan University Medical Sciences...
The NBN gene, also known as NBS1, is located on the chromosome band 8q21.3, and encodes a 754-amino acid-long protein named nibrin. This member of MRE1-RAD50-NBN nuclear complex, involved in numerous cell processes essential for maintaining genomic stability. Heterozygous variants including p.I171V, c.657del5 p.R215W, have been described risk factors development several malignancies. However, there no report regarding association these mutations with lung cancer thus far. Therefore, present...
The aim of this study is to describe the prevalence single single-nucleotide polymorphisms (SNPs) as well their combinations in genes encoding proteins involved immune response children with bacterial meningitis. prospective group consisted 39 meningitis and 49 family members surveyed between 2012 2016. Eleven SNPs seven were analysed. mean number minor frequency alleles (MAF) studied was lowest control highest patients pneumococcal We found that carrying ≥6 MAF associated an increased risk...
Detection of extended-spectrum beta-lactamases (ESBLs) could be a major challenge for microbiologists--the difficulties arise mainly from the phenotypic differences among strains.Evaluation ESBLs was performed on 42 strains E. coli by: 1) DDST MHA, 2) MHA with cloxacillin, 3) CT according to CLSI, 4) 5) Etest ESBL (AB Biodisk), 6) CHROMagarTM (GRASO), 7) ChromID® (bioMérieux), and 8) automatic system VITEK2 test (bioMérieux).Positive results were obtained 20 using method 1, 18 2, 17 by 3, 14...
It is suggested that the tumor suppressor p53 gene, classified as an interferon-stimulated implicated in interferon (IFN)-mediated innate immunity against viruses. This study aimed to examine transcriptional response of gene hepatitis C virus (HCV) infection and IFN-based therapy chronic (CHC) patients. The included 65 CHC patients (HCV genotype 1), treated with pegylated IFN-α ribavirin, 51 healthy individuals. expression was quantified by real-time polymerase chain reaction peripheral...
Conclusions Autofluorescence spectroscopy may be a supporting tool for differential diagnosis of changes in laryngeal epithelium. Objectives Early detection and proliferative the larynx are still challenge laryngologists. The aim study was to evaluate autofluorescence technique vitro pathological epithelium larynx. Methods Forty-two patients aged 34–79 years were included study. fifty-two tissue specimens, including 10 samples cancerous lesion, adjacent normal tissue, chronic inflammation,...
The NBN gene product is part of the MRE11/RAD50/NBN complex, which plays an essential role in genomic stability. In study we try to answer question what effect irradiation on DNA synthesis, expression and chromosomal stability cells with homozygous c.657-661del, heterozygous p.I171V p.R215W mutations.Immortalized B-lymphocytes mutations were X-ray irradiated at doses 1, 2, 5 8 Gy/min. Radioresistant synthesis rate percentage phase S was analyzed by 3H thymidine BrdU incorporation assays....
Background. The prognosis concerning the treatment of patients with chronic hepatitis C (CHC) is closely related to genotype virus as well factors dependent on patient. It was proved that polymorphisms gene encoding interleukin 28B (IL28B) are associated sustained viral response, which in case profitable variants IL28B may reach up 87% patients.Objectives. aim study determine prevalence alleles and distribution genotypes examined group CHC Wielkopolska Province.Material Methods. A total 710...
IBD-disability score (IBD-DS) comprises the following domains: demographics, mobility, gastrointestinal-related problems, selfcare, major life activities, mental health and interaction with environment. The aim of our study was to translate Portuguese establish validity IBD-DS. Methods: Prospectively, patients Crohn’s disease (CD) ulcerative colitis (UC) completed a version IBD-DS, short inflammatory bowel questionnaire (SIBDQ). Harvey Bradshaw (HB) for CD partial Mayo (pMayo) UC were also...
Objective. Development of midazolam (MDZ) pharmacokinetic model is pivotal for predicting drug response and determining appropriate dosing in patients who undergo surgical procedures. The aim this study was to provide population analysis describing MDZ its main metabolite 1-OH-midazolam (1-OH-MDZ) used during oral premedication paediatric patients. influence gender, age, body weight on pharmacokinetics also investigated.Material Methods analyzed data set included 27 patients, aged 1 17...
Terapia antybiotykami makrolidowymi może mieć niekorzystny wpływ na funkcjonowanie układu pokarmowego. Szczególnie podatna uszkodzenia, wynikające ze stosowana tej grupy leków, jest wątroba. W pracy zaprezentowano możliwe sposoby profilaktyki i ochrony, które mogą być wdrażane podczas terapii ant