A5090776088- Antibiotics Pharmacokinetics and Efficacy
- Forensic Toxicology and Drug Analysis
- Cancer therapeutics and mechanisms
- Analytical Methods in Pharmaceuticals
- Poisoning and overdose treatments
- Pharmacological Effects and Assays
- Lanthanide and Transition Metal Complexes
- Psychedelics and Drug Studies
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Drug Transport and Resistance Mechanisms
- Pain Management and Opioid Use
- Electron Spin Resonance Studies
- Treatment of Major Depression
- Restraint-Related Deaths
- Crystallization and Solubility Studies
- Pain Mechanisms and Treatments
- X-ray Diffraction in Crystallography
- Phenothiazines and Benzothiazines Synthesis and Activities
- Medicinal Plants and Bioactive Compounds
- Alcohol Consumption and Health Effects
- Pharmacological Effects of Natural Compounds
- Opioid Use Disorder Treatment
- Renal function and acid-base balance
- Acute Lymphoblastic Leukemia research
Poznan University of Medical Sciences
2015-2024
Heliodor Swiecicki Clinical Hospital
2004-2021
Context: In addition to designer benzodiazepines such as etizolam, deschloroetizolam, pyrazolam, diclazepam, nifoxipam, or clonazolam, a new psychoactive substance like flubromazolam, triazole of flubromazepam has become available. Flubromazolam is currently not marketed medication but rather research chemical and recreational drug. It mostly causes sedative effects also moderate anti-anxiety muscle relaxant effects. A case severe intoxication flubromazolam been reported. Case details:...
This study aimed to assess the analgesic efficacy of oxycodone at doses 10 mg and 20 in dressings after surgery burn wounds. Twenty adult patients who underwent surgical treatment third-degree wounds under general anaesthesia were included. Burn treated with dressings, which was added Group 1 2. After surgery, plasma noroxycodone concentrations assayed, pain intensity assessed Numerical Rating Scale (NRS). In 1, no patient reported pain; 2, four pain. The intensity, according NRS, 1-8....
Abstract In this paper the decomposition product of levofloxacin was identified. Levofloxacin dissolved in 0.9% NaCl, 5% glucose, and Ringer’s solution. The solutions were divided into two batches: first one exposed to daylight second protected from it. stored at room temperature. qualitative analysis degradation performed using MS TOF detectors. quantitative assay done by a validated HPLC method. Visual inspection pH assessment done. remained stable dextrose, A slight analyte observed with...
Cytochromes P450 family 1 ( CYP 1) are responsible for the metabolism of procarcinogens, example polycyclic aromatic hydrocarbons and heterocyclic amines. The inhibition activity is examined in terms chemoprevention cancer chemotherapy. We designed synthesized a series trans ‐stilbene derivatives possessing combination methoxy methylthio functional groups attached different positions to skeleton. determined effects compounds on activities human recombinant 1A1, 1A2 1B1 and, explain variation...
A stability-indicating high-performance liquid chromatography (HPLC) of hydrophilic interactions was developed and validated for the determination cetirizine dihydrochloride in bulk substance pharmaceutical dosage form. The separation achieved on a Poroshell 120 Hilic (4.6 × 150 mm, 2.7 μm) column using mobile phase composed acetonitrile–0.1% formic acid (20:80 v/v) at flow rate 1.0 mL/min. injection volume 5.0 μL wavelength detection controlled 235 nm. method by evaluating linearity,...
Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was assess the efficacy and safety oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA).In 11 (American Society Anesthesiologists physical status classification system II/III, age range: 59-82 years), THA conducted with using 15 mL 0.25% bupivacaine (37.5 mg) 5 mg sedation propofol infusion at a dose 3-5 mg/kg/h. After surgery, received ketoprofen 100...
Unconventional (alternative, natural) medicine in Poland and worldwide includes hundreds of non-scientifically verified "treatment" modalities. Among the most popular are biological therapies using chemical or natural compounds administered with injection drip infusion. The latter has found excellent use treating rheumatological dermatological diseases certain types cancer. Vitamin infusions, curcumin, glutathione, perhydrol dimethylsulphoxide (DMSO) have gained popularity among clients...
Treosulfan is a prodrug applied in the treatment of ovarian cancer and conditioning prior to stem cell transplantation. So far, bioanalysis treosulfan either whole blood or red cells (RBC) has not been carried out. In this work, RBC/plasma partition coefficient (Ke/p) its active monoepoxide was determined for first time. Male female 10-week-old Wistar rats (n = 6/6) received an intraperitoneal injection at dose 500 mg/kg body weight. The concentrations plasma (Cp) RBC were analyzed with...
The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg pamoate. Clinical symptoms PDSS were similar to those acute oral intoxication. patient received supportive treatment recovered fully. High concentrations serum, with maximum level 698 ng/mL, confirmed by liquid chromatography tandem spectrometry...
In recent years, the administration of fentanyl (FNTL) implicitly in transdermal drug delivery systems (TDDS) has vastly increased chronic pain treatment. Non-medical and uncontrolled use FNTL TFDS (transdermal systems) may reveal toxic effects by route exposure, dermal or alternative, ingestion patches, release stomach. The purpose this study was to present three different cases poisonings, two which resulted death due abuse. first case is a 66-year-old woman treated for accidental FTNL...