A5033714344- Cancer therapeutics and mechanisms
- Drug Solubulity and Delivery Systems
- Hematopoietic Stem Cell Transplantation
- Antibiotics Pharmacokinetics and Efficacy
- Acute Lymphoblastic Leukemia research
- Gastrointestinal motility and disorders
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Electron Spin Resonance Studies
- Chemical Reaction Mechanisms
- Lanthanide and Transition Metal Complexes
- Crystallization and Solubility Studies
- Pharmacogenetics and Drug Metabolism
- Neonatal Health and Biochemistry
- DNA and Nucleic Acid Chemistry
- Ocular Oncology and Treatments
- Adsorption, diffusion, and thermodynamic properties of materials
- Drilling and Well Engineering
- Microencapsulation and Drying Processes
- Free Radicals and Antioxidants
- Polyomavirus and related diseases
- Nanoplatforms for cancer theranostics
- Particle Detector Development and Performance
- Cardiac Arrhythmias and Treatments
Poznan University of Medical Sciences
2015-2025
Heliodor Swiecicki Clinical Hospital
2010-2020
Medac (Germany)
2015
Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility a reasonable time. This study, for first time, combines novel apparatus with design (DoE) and machine learning (ML) to overcome this obstacle. The workflow involves testing soft gelatin capsules set fasted-state biorelevant created DoE. results are used by an ML algorithm build classification model capsule's opening...
Virtual bioequivalence trial (VBE) simulations based on (semi)mechanistic in vitro-in vivo (IVIV) modeling have gained a huge interest the pharmaceutical industry. Sophisticated commercially available software allows variable drug fates gastrointestinal tract (GIT). Surprisingly, between-subject and inter-occasion variability (IOV) of distribution volumes clearances are ignored or simplified, despite substantially contributing to varied plasma concentrations. The paper describes novel...
Variability of the gastrointestinal tract is rarely reflected in
studies of formulation performance with
Mathematical models that treat the fed stomach content as a uniform entity emptied with constant rate may not suffice to explain pharmacokinetic profiles recorded in clinical trials. In reality, phenomena such Magenstrasse or chyme areas of different pH and viscosity, play an important role intragastric drug dissolution its transfer intestine. this study, we investigated data gathered bioequivalence trial between immediate-release tablet (Reference) orally dispersible (Test) poorly soluble...
Treosulfan (TREO) is currently investigated as an alternative treatment of busulfan in conditioning before hematopoietic stem cell transplantation. The knowledge the blood-brain barrier penetration drug still scarce. In this paper, TREO and its active monoepoxide (S,S-EBDM) diepoxide (S,S-DEB) into CNS was studied juvenile (JR) young adult rats (YAR) for first time. CD both sexes (<i>n</i> = 96) received intravenous dose 500 mg/kg b.wt. Concentrations TREO, S,S-EBDM, S,S-DEB rat plasma,...
Treosulfan is a prodrug applied in the treatment of ovarian cancer and conditioning prior to stem cell transplantation. So far, bioanalysis treosulfan either whole blood or red cells (RBC) has not been carried out. In this work, RBC/plasma partition coefficient (Ke/p) its active monoepoxide was determined for first time. Male female 10-week-old Wistar rats (n = 6/6) received an intraperitoneal injection at dose 500 mg/kg body weight. The concentrations plasma (Cp) RBC were analyzed with...
Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. Treosulfan converts nonenzymatically the monoepoxide intermediate (EBDM), and then (2S,3S)-1,2:3,4-diepoxybutane (DEB). The latter alkylates DNA forming mainly (2′S,3′S)-N-7-(2′,3′,4′-trihydroxybut-1′-yl)guanine (THBG) (2S,3S)-1,4-bis(guan-7′-yl)butane-2,3-diol cross-link (bis-N7G-BD) via epoxide adduct (EHBG). It is believed that...