A5051735076- Drug Solubulity and Delivery Systems
- Rough Sets and Fuzzy Logic
- Protein purification and stability
- Statistical and Computational Modeling
- Analytical Methods in Pharmaceuticals
- Microencapsulation and Drying Processes
- Pharmacological Effects of Natural Compounds
- Solar and Space Plasma Dynamics
- Advanced Thermodynamics and Statistical Mechanics
- Pharmaceutical studies and practices
- Natural product bioactivities and synthesis
- Solar Radiation and Photovoltaics
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Polysaccharides Composition and Applications
- Advanced Drug Delivery Systems
Adamed (Poland)
2018-2024
University of Colorado Boulder
2023
Nicolaus Copernicus University
2016-2018
Virtual bioequivalence trial (VBE) simulations based on (semi)mechanistic in vitro-in vivo (IVIV) modeling have gained a huge interest the pharmaceutical industry. Sophisticated commercially available software allows variable drug fates gastrointestinal tract (GIT). Surprisingly, between-subject and inter-occasion variability (IOV) of distribution volumes clearances are ignored or simplified, despite substantially contributing to varied plasma concentrations. The paper describes novel...
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending a drug substance(s) with excipients followed by compressing powder mixture into In this study, immediate-release film-coated tablets containing either Sitagliptin phosphate or hydrochloride were developed using DC technique. After establishing optimum ratio ductile brittle excipients, five formulations compressed rotary press finally film...
Mathematical models that treat the fed stomach content as a uniform entity emptied with constant rate may not suffice to explain pharmacokinetic profiles recorded in clinical trials. In reality, phenomena such Magenstrasse or chyme areas of different pH and viscosity, play an important role intragastric drug dissolution its transfer intestine. this study, we investigated data gathered bioequivalence trial between immediate-release tablet (Reference) orally dispersible (Test) poorly soluble...
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on inert cores made microcrystalline cellulose, sucrose and isomalt prepared. The developed consisted two types drug-layered attaining different release patterns: delayed-release (enteric-coated) extended-release. Dissolution characteristics...
(2020). The use of novel tools for the assessment powders and granules flow properties analysis minitablets compression process. Drug Development Industrial Pharmacy: Vol. 46, No. 4, pp. 547-556.
Multiple-unit pellet systems (MUPS) offer many advantages over conventional solid dosage forms both for the manufacturers and patients. Coated pellets can be efficiently compressed into MUPS in classic tableting process enable controlled release of active pharmaceutical ingredient (APIs). For patients are divisible without affecting drug convenient to swallow. However, maintaining API profile during compression a challenge. The aim this work was explore discover relationships between data...
The objective of this study was to identify cause-effect relationships between various data related vaginal dosage forms, such as composition, process parameters (condition attributes), and quality (decision attribute), by employing a mathematical mining approach that utilizes Rough Set Theory. analyzed were organized in tabular format known an information system. Objects labeled rows, attributes columns, with attribute-values serving entries. Each formulation described its condition...
Abstract The aim of this work was to develop a cream formulation with potential antioxidant properties. Herein, freeze-dried extract Ligusticum mutellina used as source active compounds. proposed qualitative composition the characterized by good polyphenolic compounds release profile. Of note, highest R 2 adj values were obtained for Korsmeyer-Peppas and Higuchi models (0.9159 0.9226, respectively). These results indicate that L. , due its retained high phenolic acids content, could become...