A5000298365- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Energetic Materials and Combustion
- Crystallography and molecular interactions
- Protein purification and stability
- Synthesis and properties of polymers
- Polymer Synthesis and Characterization
- Microwave-Assisted Synthesis and Applications
- Thermal and Kinetic Analysis
- Spectroscopy and Chemometric Analyses
- Chronic Myeloid Leukemia Treatments
- Protein Interaction Studies and Fluorescence Analysis
- Polysaccharides Composition and Applications
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Enzyme Production and Characterization
- Analytical Chemistry and Chromatography
- Microencapsulation and Drying Processes
Adamed (Poland)
2021-2024
Wroclaw Medical University
2014-2021
University of Wrocław
2014
Prepared solid dispersions were applied to a drug with low water solubility improve its dissolution rate. Fenofibrate (FEN) is Biopharmaceutical Classification System (BCS) class-II (poorly water-soluble) drug, and bioavailability limited by the The physical state of FEN in Pluronic F127 (PLU) prepared using fusion method was assessed Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC). DSC investigation revealed that PLU...
Purpose: To evaluate the physicochemical properties of clotrimazole (CLT) solid dispersion with Pluronic F127 (PLU).Methods: Solid dispersions antifungal drug, clotrimazole, were prepared using grinding (PM) and fusion (FUS) methods. Physicochemical characterization performed differential scanning calorimetry (DSC), x-ray powder diffraction (XRPD) Fourier transform infrared spectroscopy (FTIR). In vitro drug release was carried out rotating disc method.Results: These studies showed that...
Lovastatin (LOV) is widely used for the treatment of hypercholesterolemia. The poor water solubility LOV leads to its gastrointestinal absorption and results in bioavailability. In this study, a preparation solid dispersions with acetylsalicylic acid (ASA) was studied improve dissolution rate LOV. Solid were prepared using various mass ratios both components through grinding method. Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) X-ray powder...
The crystallisation of metastable drug polymorphs in polymer matrices has been reported as a successful approach to enhance the solubility poorly water-soluble molecules. This can be achieved using different polymers, ratios and formulation techniques enabling formation stable nuclei subsequent growth new or polymorphs. In this work we elucidated polymorphism behaviour model compound fluconazole (FLU) embedded solid dispersions with amorphous Soluplus® (SOL) obtained spray drying fusion...
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as model drug in the form of hard gelatin capsules. For comparative purposes, corresponding formulations based on inert cores made microcrystalline cellulose, sucrose and isomalt prepared. The developed consisted two types drug-layered attaining different release patterns: delayed-release (enteric-coated) extended-release. Dissolution characteristics...
Mathematical models that treat the fed stomach content as a uniform entity emptied with constant rate may not suffice to explain pharmacokinetic profiles recorded in clinical trials. In reality, phenomena such Magenstrasse or chyme areas of different pH and viscosity, play an important role intragastric drug dissolution its transfer intestine. this study, we investigated data gathered bioequivalence trial between immediate-release tablet (Reference) orally dispersible (Test) poorly soluble...