A5026756876- Acute Lymphoblastic Leukemia research
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
- Pregnancy and Medication Impact
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Pharmaceutical Economics and Policy
- Antifungal resistance and susceptibility
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Drug Transport and Resistance Mechanisms
- Medication Adherence and Compliance
- Drug-Induced Hepatotoxicity and Protection
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Lymphocytic Leukemia Research
- Patient Safety and Medication Errors
- Biosimilars and Bioanalytical Methods
- Analytical Methods in Pharmaceuticals
- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Pharmacology and Obesity Treatment
- Nausea and vomiting management
Wroclaw Medical University
2014-2024
Górnośląskie Centrum Medyczne
2021
Niepubliczna Wyższa Szkoła Medyczna
1997-2003
Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across globe gradually identified need to focus more on ensuring appropriate use medicines improve patient outcomes rather than being engaged in manufacturing supply. Since that time numerous studies have shown positive impact clinical services (CPS). The for wider adoption CPS worldwide becomes urgent, global population ages, prevalence polypharmacy well shortage healthcare...
Abstract Introduction Use of higher than standard doses amikacin (AMK) has been proposed during sepsis, especially to treat less susceptible bacterial strains. However, few data are available on drug concentrations prolonged therapy and potential adverse events related this strategy. Methods Sixty-three critically ill patients who required AMK administration for the treatment severe infection were included in study. After a loading dose (LD, 18 30 mg/kg), daily regimen was adapted using...
The safety of pharmacotherapy for geriatric patients is an essential aspect the demographic perspective in view increasing size this population. Non-opioid analgesics (NOAs) are among most popular and often overused over-the-counter medications (OTC). reasons drug abuse common population: musculoskeletal disorders, colds, inflammation pain various origins. popularity self-medication ability to easily access OTC drugs outside pharmacy creates danger their misuse incidence adverse reactions...
Background. Modern anticancer chemotherapy can cause numerous adverse effects in the organism, whose functioning has already been disrupted by neoplastic process itself.Objectives. The aim of study was to evaluate and compare frequency severity toxicity FOLFOX-4 CLF-1 therapy patients with colon cancer, analyze certain factors that might have increased chemotherapy.Material Methods. involved 64 suffering from generalized including 48 treated according regimen 16 regimen. each analyzed on...
Background. Postoperative nausea and vomiting (PONV) is a common complication after anesthesia surgery. Ondansetron one of the most widely used drugs in prophylaxis PONV extensively metabolized humans. In vitro metabolism studies have shown that ondansetron substrate for human hepatic cytochrome P450 enzymes. The (human [CYP]) 2D6 inhibitor quinidine reduced hydroxylation ondansetron, which indicates important role CYP2D6 metabolism. Genotyping these alleles allows prediction extensive...
The aim of this study was to determine the influence different CYP2C19 genotypes on selected liver function parameters, and ADR occurrence during VCZ prophylaxis in adult patients after allo-HSCT (allogeneic hematopoietic stem cell transplantation). mutations were determined a cohort 30 adults using PCR-RFLP methods established by Sim et al. Goldstein Blaisdell. patients' protocol included biometrical biochemical data, information underlying disease, chemotherapy, molds infections occurring...
Nifuroxazide (4-hydroxy-benzoic acid; 2-[(5nitro-2-furanyl)methylene]hydrazide) is a chemotherapeutic agent belonging to the nitrofuran family.Indications for its use are acute and chronic bacterial diarrhea other diseases with (1).The drug has local antibacterial activity against some Gram-positive bacteria of genus Staphylococcus Gram-negative from Enterobacteriaceae family: Yersinia spp., Escherichia Enterobacter Klebsiella spp.and Salmonella spp.It does not affect Proteus vulgaris,...
The aim of this work was to study methotrexate (MTX) kinetics and their relation the effectiveness therapy in patients with rheumatoid arthritis (RA). Other aims were analyze influence MTX on liver, kidney, hematopoietic function determine possibility using early drug concentrations predict subsequent value treatment.The observations carried out 49 RA after first dose 7 months treatment. Methotrexate blood serum urine determined fluorescence polarization immunoassay applying a TDx Abbott...
Depression is a global mental health concern, and personalized treatment approaches are needed to optimize its management. This study aimed investigate the influence of CYP2D6 CYP1A2 gene polymorphisms on efficacy duloxetine in reducing depressive anxiety symptoms. A sample 100 outpatients with major depression, who initiated monotherapy duloxetine, were followed up. Polymorphisms genes assessed. The severity symptoms was recorded using standardized scales. Adverse drug reactions (ADRs)...
Voriconazole (VCZ) is a new-generation triazol antifungal agent. CYP2C19 mutations have been reported to cause variability in VCZ pharmacokinetics, and thus lead undesirable effects of pharmacotherapy. We observed four Caucasian patients who underwent allogenic hematopoietic stem cell transplantation, treated with voriconazole for prevention fungal infections, establish the impact CYP2C19*2/*17 genotype on side effect occurrence. Genetic testing allele*2 and*17 was performed using two...
The purpose of the present work was estimation liver function using phenazone test and commonly used biochemical tests in children with acute lymphoblastic leukemia (ALL) during anticancer treatment.Observations were carried out same 21 patients ALL before beginning chemotherapy, after Protocol I M antileukemic treatment according to program BFM 86.The applied chemotherapy inhibited elimination. Both half-life metabolic clearance rate significantly different drugs, especially high-dose...