A5072847615- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Skin Diseases and Diabetes
- Biosimilars and Bioanalytical Methods
- Viral Infections and Immunology Research
- Acute Lymphoblastic Leukemia research
- Bone and Joint Diseases
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Inflammatory Myopathies and Dermatomyositis
- Urticaria and Related Conditions
Wroclaw Medical University
2015-2024
Center for Rheumatology
2024
Niepubliczna Wyższa Szkoła Medyczna
2001-2011
Szpital Kliniczny Nr 1 we Wrocławiu
2011
University of Wrocław
1987-2004
To assess the long-term safety and efficacy of Janus kinase inhibitor upadacitinib versus adalimumab over 3 years in ongoing extension (LTE) SELECT-COMPARE, a randomised controlled phase trial patients with active rheumatoid arthritis inadequate response to methotrexate (MTX).Patients on stable background MTX were 2:2:1 15 mg, placebo or 40 mg. Patients an insufficient switched by week 26 from upadacitinib, upadacitinib. who completed 48-week double-blind period could enter LTE for up 10...
A variety of disease-modifying antirheumatic drugs (DMARDs) are available to control the clinical activity rheumatoid arthritis (RA). Methotrexate (MTX), an analogue folic acid and aminopterin, is most commonly used DMARD now prescribed worldwide at least 500,000 patients with RA. The mechanism by which MTX a low dose modulates inflammation in RA still unknown. Monitoring therapy terms concentration seems not have significant influence on effectiveness treatment. Two meta-analyses showed...
MicroRNA-146a (miR-146a) has been shown to play an important role in the regulation of inflammatory innate immune responses, and found be differentially expressed rheumatoid arthritis (RA). Through NF-κB pathway, this molecule is able stimulate release pro-inflammatory cytokines such as TNF-α, IL-1β, IL-17. It also suggested that single-nucleotide polymorphisms (SNPs) miRNA sequences may alter expression miR-146a rs2910164 SNP contribute RA development. These observations prompted us analyze...
To assess the safety and efficacy of upadacitinib versus adalimumab from SELECT-COMPARE over 5 years. Patients with rheumatoid arthritis inadequate response to methotrexate were randomised receive 15 mg once daily, placebo or 40 every other week, all concomitant methotrexate. By week 26, patients insufficient treatment rescued; remaining on switched upadacitinib. completing 48-week double-blind period could enter a long-term extension. Safety assessed through 264, radiographic progression...
Rheumatoid arthritis is a chronic autoimmune-based inflammatory disease that leads to progressive joint degeneration, disability, and an increased risk of cardiovascular complications, which the main cause mortality in this population patients. Although several biomarkers are routinely used management rheumatoid arthritis, there high demand for novel further improve early diagnosis stratification patients, prediction better response specific therapy. In study, metabolomics approach was...
There are no reliable data regarding the prevalence of rheumatoid arthritis (RA) in Poland.The first stage was a face-to-face survey on nationwide representative sample 3000 people, which identified respondents with physician-confirmed diagnosis RA. The second RA patients, characterized disease course and treatment. It evaluated by analysis group 1957 patients routine clinical practice.The overall Poland 0.9% (95% CI: 0.6-1.2%), 1.06% for women, 0.74% men. Seventy-eight percent were female,...
Renal failure in the course of rheumatoid arthritis (RA) is a consequence many factors, including drug-induced nephrotoxicity, comorbidities and chronic inflammation. Contemporary treatment strategies have reduced incidence renal population RA patients. However, it remains problem for approximately 25% Therefore, special attention should be paid to potential need dosage modifications administered medications. Many drugs used therapy rheumatic diseases not been thoroughly studied their safety...
POLSKIE ARCHIWUM MEDYCYNY
Background. Research is still being conducted in order to determine the mechanisms responsible for initiation of rheumatoid arthritis (RA) as well its persistence and progression.Objectives. The aim this work was establish expression signal transducer activator transcription (STAT) factors nuclear factor kappa-light-chain-enhancer activated B cells (NFκB) peripheral blood leukocytes synovial fluid cells. correlations between activation level activity disease were also analyzed.Material...
Abstract The aim of this study was to assess the prevalence periodontal disease and effect treatment in patients with rheumatoid arthritis (RA) spondyloarthritis (SpA). Forty-four RA patients, thirty SpA thirty-nine healthy volunteers were recruited study. Periodontal examination included approximal plaque index (API), bleeding on probing (BoP), depth (PD) number teeth. Samples from deepest pockets taken for detection Porphyromonas gingivalis DNA use polymerase chain reaction. All subjects...
Objective Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic (PsA) belong to inflammatory rheumatic diseases, the group of conditions unknown etiology. However, a strong genetic component in their pathogenesis has been well established. A dysregulation cytokine networks plays an important role development arthritis. Interleukin 33 (IL-33) is recently identified member IL-1 family. To date, significance IL-33 poorly studied. This research aimed investigate potential gene...
Involvement of the non-classical human leucocyte antigen-E (HLA-E) in both innate and acquired immune response suggests its possible role development autoimmune pathologies. This study was undertaken to investigate relationships between HLA-E gene single nucleotide polymorphisms (SNPs) a risk rheumatoid arthritis (RA), as well evaluate potential these modulate clinical outcome anti-tumour necrosis factor (TNF) treatment female patients. A total 223 patients with RA receiving anti-TNF...
Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by tissue fibrosis and immune abnormalities. Recent evidence suggests that activated circulating monocytes from patients with SSc play an important role in early stages of pathogenesis due to enhanced expression inhibitor metalloproteinases 1 (TIMP-1), IL-8 reactive oxygen species (ROS) induction. However, the exact factors contribute inflammation subsequently progression are still unknown.The pattern IL-8, TIMP-1, AP-1...
Genes involved in regulation of the nuclear factor-κB (NF-κB)-pathway are suggested to play a role pathogenesis rheumatoid arthritis (RA). In present study, genetic polymorphisms
Abstract Background To evaluate the efficacy and safety of upadacitinib monotherapy versus methotrexate (MTX) over 5 years among MTX-naïve patients with moderately to severely active rheumatoid arthritis (RA) in long-term extension (LTE) phase 3 SELECT-EARLY trial. Methods Patients were randomized receive 15 mg or 30 MTX. who did not achieve CDAI remission had < 20% improvement tender swollen joint counts at week 26 received rescue therapy (addition MTX group addition group). Efficacy...
A natural killer group 2 member D (NKG2D) acts as a powerful activating and co-stimulatory receptor on immune effector cells including NK T cells. Disruptions within the NKG2D signalling pathway may trigger an exacerbated response promote autoimmune reactions. The objective of study was to evaluate plausible role polymorphisms gene predictor how effective anti-tumor necrosis factor (TNF) therapy is in rheumatoid arthritis (RA) patients. total 280 RA patients receiving anti-TNF were genotyped...
Interleukin-2 (IL-2) has been suggested to control Treg/Th17 balance. Recently, we reported a relationship of rheumatoid arthritis (RA) activity/progression with irreversible systemic Treg and Th1 defects including serum IL-2 shortage. Herein, explore the role in vitro stimulation rIL-2 observed immune alterations reversal. Patients stable or progressive RA were assigned methotrexate (MTX) group TNF-alpha inhibitors (iTNF) group, respectively. Flow cytometric analyses performed before after...