A5029826628- Bone Tissue Engineering Materials
- Immune Response and Inflammation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- Synthesis and biological activity
- NF-κB Signaling Pathways
- Multiple Sclerosis Research Studies
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Synthesis and Reactions of Organic Compounds
- Tryptophan and brain disorders
- Herpesvirus Infections and Treatments
- Clinical Nutrition and Gastroenterology
- Cytomegalovirus and herpesvirus research
- Air Quality and Health Impacts
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Nanoparticles: synthesis and applications
- Mast cells and histamine
- Rheumatoid Arthritis Research and Therapies
- RNA Interference and Gene Delivery
Polish Academy of Sciences
2016-2025
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2016-2025
Institute of Immunology
1992-2019
Wrocław University of Science and Technology
2015
University of Wrocław
2007
Temple University
2000-2003
ABSTRACT We have examined the localization of inducible nitric oxide synthase (iNOS) and nitrotyrosine (the product nitration tyrosine by peroxynitrite, a highly reactive derivative [NO]) in demyelinating lesions from (i) two young adult patients with acute multiple sclerosis (MS), (ii) child MS (consistent diffuse sclerosis), (iii) five chronic MS. Previous reports suggested possible correlation between iNOS, related nitrogen-derived oxidants, processes demonstrated iNOS-immunoreactive...
Background. Research is still being conducted in order to determine the mechanisms responsible for initiation of rheumatoid arthritis (RA) as well its persistence and progression.Objectives. The aim this work was establish expression signal transducer activator transcription (STAT) factors nuclear factor kappa-light-chain-enhancer activated B cells (NFκB) peripheral blood leukocytes synovial fluid cells. correlations between activation level activity disease were also analyzed.Material...
Abstract Microporous scaffolds with potential applications for tissue engineering were produced from the biodegradable aliphatic isosorbide‐based polyurethane using a combined salt leaching–solvent evaporation–coagulation process. Alkaline sodium phosphate heptahydrate crystals used as solid porogene, and acetone–water mixture was nonsolvent–coagulant. The in this study had interconnected pores sizes range of 70–120 μm pore‐to‐volume ratio 87%. XPS measurements showed that residence scaffold...
A series of esters 4-acetyl, 4-trifluoroacetyl- and 4-(3-chloropropionyl)aminobenzenethiosulfoacids (twenty-four compounds) were synthesized characterized by elemental analysis, 1H NMR IR spectroscopy. The antibacterial activity the novel candidates has been screened using agar diffusion or serial dilution methods against representative Gram-positive (Staphylococcus aureus, Bacillus subtilis, mesentericus, Mycobacterium sp., luteum), Gram-negative (Aeromonas Burkholderia cepacia, Alcaligenes...
Background: Prolonged psychic stress leads to immune suppression, which preferentially affects the cellular response. Yolkin is an egg-derived protein with firmly established immunoregulatory activities in rodent models. Objective: The aim of this work was evaluate effects oral administration yolkin, when mice experience prolonged exposure immobilization stress, on vivo and vitro parameters contact sensitivity (CS) oxazolone (OXA). Materials Methods: BALB/c were exposed 5-day followed by...
Protease-mediated degradation of proteins is critical in a plethora physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together with lactoferrin (LF) as first cellular immune response against pathogens. Here, we demonstrate that LF increases the catalytic activity CatG at concentration, its highest enhancing capacity under acidic (pH 5.0) conditions, broadens substrate selectivity CatG. On functional...
In response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants osseous tissue regeneration made a newly developed blend poly(l-lactide-co-glycolide) (PLGA) syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been fabricated. Afibre-forming copolymer glycolide l-lactide was obtained unique method synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The are composed three layers PLGA...
Abstract The paper presents results of the studies on porous composites obtained using lyophilization method based solutions following polymers: chitosan, sodium alginate and polylactide, as well ZnO‐doped CaO–SiO 2 –P O 5 bioglass. researchers took advantage zinc ions demonstrating bactericidal, immune‐stimulating, tissue‐regenerating functions in organism. cytotoxicity was tested L929 cells by means direct indirect contact method. antibacterial properties were determined against...
A series of new mono and disubstituted alkylated methoxylated benzisoselanzol-3(2H)-ones bis(2carbamoylaryl)diselenides were prepared in yields ranging from 55% to 95% starting anthranilic acid evaluated for antiviral antimicrobial activity.The compounds exhibited activity against Human herpes virus 1 Encephalomyocarditis as well Staphylococcus aureus, Bacillus subtilis, Escherichia coli Candida albicans.
The aim of the study was to produce biocomposites based on chitosan and sodium hyaluronate hydrogels supplemented with bioglasses obtained under different conditions (temperature, time) perform an in vitro evaluation their cytocompatibility using both indirect direct methods. Furthermore, release ions from composites microstructure before after incubation simulated body fluid were assessed. Tests extracts hydrogel performed A549 epithelial cells, while MG63 osteoblast-like cells tested...
Abstract We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated antiviral actions lactoferrin in splenocytes infected with Encephalomyocarditis virus ( EMCV ). Recombinant mouse (rmLF) bovine (bLF) were used. There no differences studied age categories. Both types lactoferrins protective mice. The study confirmed undisturbed resistance mice infection. action homologous was demonstrated for first time.
Cytotoxic effect of natural 5-n-alkylresorcinol fraction, individual homologs and some related compounds (resorcinol, orcinol olivetol) was tested in vitro against mouse fibroblast cell line L929 terms their safety for use according to PN-EN ISO 10993-5:2009 method. Alkylresorcinol-rich fraction five known alkylresorcinol (C17:0, C19:0 C21:0, C23:0 C25:0) were obtained from spelt (Triticum spelta L.) bran. The structures these elucidated confirmed by using two spectroscopic techniques: MS...
Abstract Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim the study was to create and evaluate hybrid polymeric 3D scaffold consisted nano microfibers, which could be used bone engineering. Hybrid structures were fabricated using rapid prototyping (RP) electrospinning (ES) methods. Electrospun nanofibrous mats incorporated between microfibrous layers produced by RP technology. nanofibers made poly(L-lactid)...
The synthesis of a series novel 7-aminooxazolo[5,4-d]pyrimidines 5, transformations during their and physicochemical characteristics have been described. Complete detailed spectral analysis the intermediates 2–4, N′-cyanooxazolylacetamidine by-products 7 final compounds 5 has carried out using MS, IR, 1D 2D NMR spectroscopy. Theoretical research was to explain privileged formation in relation possibility isomer related thermodynamic aspects. Additionally, single-crystal X-ray diffraction for...