A5007521269- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Tracheal and airway disorders
- Myasthenia Gravis and Thymoma
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Protease and Inhibitor Mechanisms
- Cancer-related Molecular Pathways
- Neurofibromatosis and Schwannoma Cases
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Shoulder and Clavicle Injuries
- Restraint-Related Deaths
- Gastrointestinal disorders and treatments
- Cancer Diagnosis and Treatment
Medical University of Lodz
2015-2024
Copernicus Memorial Hospital
2015-2024
Lublin Oncology Center
2018-2019
Wojewódzki Szpital Specjalistyczny Nr 2
2012
The ABCB1 gene belongs to ATP binding cassette (ABC) transporter genes that has been previously implicated in cancer progression and drug response. This study aimed evaluate the association between SNP 3435 expression of lung patients Polish population comparison clinicopathological parameters treatment. 150 RNA 47 DNA samples were isolated from 49 cases including both tissue blood taken same at three time points: diagnosis, 100 days one year after surgical intervention. Qualitative...
Abstract Background The RAS family protooncogenes, including KRAS , NRAS and HRAS encode proteins responsible for the regulation of growth, differentiation survival many cell types. oncogene mutations are well defined, however, clinical significance expressions in non–small-cell lung cancer (NSCLC) is still uncertain. Methods A total 39 whole blood samples NSCLC (the investigated group), collected at three points time: time diagnosis, 100 days 1 year after surgery as 35 tissue obtained...
The aim of the study was to determine a prognostic value neutrophil lymphocyte ratio (NLR), platelet (PLR) and monocyte (LMR) ratios for survival patients, operated on due non-small cell lung cancer (NSCLC).The conducted 532 NSCLC, in stages IA-IIIA. A total 174 females 358 males, aged 36-84 years (the mean age: 63.6 years) were included study. following factors subject statistical analysis, determination potential values NLR, PLR LMR ratios: age, sex, nicotinism, number leukocytes,...
The aim of the study was to determine prognostic significance PLR and NLR ratios in patients operated due non-small cell lung cancer.The group consisted 532 (174 women, 358 men) with cancer (NSCLC) staged IA-IIIA. mean age 63.6 years (range 36 84 years). Together platelet/lymphocyte ratio (PLR) neutrophil/lymphocyte (NLR), following factors were included statistical analysis: age, sex, smoking history, number leukocytes, neutrophils, platelets, histopathology, T-stage, N-stage, concomitant...
The aim of the study was to determine a survival prognostic value selected blood morphological rates patients, operated on due non-small cell lung cancer (NSCLC).The conducted 532 surgically treated NSCLC, in stages IA-IIIA, 174 females and 358 males, mean age 63.6 years (36-84 years) were included study. Blood parameters clinical factors statistical analysis, order potential values red distribution width-standard deviation (RDW-SD), corpuscular volume (MCV) hemoglobin. Factors contained:...
In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in microenvironment, including extracellular matrix (ECM), which is not only a scaffold for cells, but also reservoir cytokines, chemokines growth factors. Metalloproteinases (MMPs) among elements that enable ECM remodeling. The publication focuses on problem gene expression MMP2, MMP9 tissue inhibitor metalloproteinases (TIMP1) blood NSCLC patients during therapy (one year after surgical...
One of the most important prognostic factors in non-small cell lung cancer (NSCLC), a condition with high mortality rate, is presence mediastinal lymph node metastases alongside distant metastases. The aim this study was to evaluate value selected parameters N2 stage NSCLC special focus on ratio (LNR).
The analysis concerned the comparison of expression membrane type matrix metalloproteinases genes in blood and tissue NSCLC patients during course disease to control group. Blood neoplastic taken from 45 diagnosed with non-small cell lung cancer was a research material. level MMP14, MMP15, MMP16 MMP24 evaluated by qPCR results were compared controls. MMP14 before tumor removal surgery 100 days after lower than Interestingly, one year levels these identical those This suggests that...
Tumours of the sternum are rare and can be malignant, benign or inflammatory.To determine clinical, pathological therapeutic options for tumours sternum.We report a series 30 cases sternal treated in our institution period 2006-2015. There were 10 malignant located body sternum, 2 manubrium (metastases kidney thyroid carcinoma) 18 different parts sternum. Diagnosis was obtained by computed tomography scan chest, surgical biopsy excision tumours.Malignant excised radically. Reconstruction...
We aimed to investigate the clinical significance of left lower paratracheal nodes (#4L) and their impact on survival in patients with left-sided lung cancer.This was a retrospective analysis prospective data. The study included 5369 who underwent surgery between 2005 2015. Six hundred fifty-nine #4L dissection (4LND+), 4710 did not (4LND-). Propensity score matching used minimize analytic error (659 vs 659).The percentage metastasis increased tumour size. Between pT2a pT2b, it nearly...
Histopathologic differentiation between the stages of Barrett's carcinogenesis is often challenging. Liver-intestine (LI)-cadherin, an intestine-specific marker, involved in intestinal metaplasia development gastric and colon cancers could be value diagnosis differentiation.To examine expression LI-cadherin sequence to evaluate its association with clinicopathological data.LI-cadherin was immunohistologically investigated, by use anti-CDH17 antibody, mucosa (GM) biopsies taken from cardia (n...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Łochowski MP, Brzeziński D, Kozak J. Videothoracoscopy in the treatment of benign neurogenic tumours posterior mediastinum. Videosurgery and Other Miniinvasive Techniques. 2014;9(3):315-318. doi:10.5114/wiitm.2014.44255. APA Łochowski, M. P., Brzeziński, D., & Kozak, (2014). Techniques, 9(3), 315-318. https://doi.org/10.5114/wiitm.2014.44255 Chicago Mariusz P, Daniel Józef Kozak. 2014. "Videothoracoscopy...
The aim of the study is to analyse 5-year survival and prognostic factors in patients operated due lung cancer with postoperatively confirmed metastases N2 group nodes.In years 2007-2015, 1,148 were treated surgically. A postoperative histopathological feature 150 patients. One hundred ten patients, whom a analysis was possible perform, included such analysis. underwent following procedures: pneumonectomy, 31 patients; lobectomy, 61; bilobectomy, 10; wedge resection, 8. All subjected...
AMA Łochowski M, Kaczmarski J, Brzeziński D, Cieślik-Wolski B, Kozak J. Penetrating neck traumas. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2014;11(1):30-33. doi:10.5114/kitp.2014.41927. APA Łochowski, M., Kaczmarski, J., Brzeziński, D., Cieślik-Wolski, B., & Kozak, (2014). Surgery, 11(1), 30-33. https://doi.org/10.5114/kitp.2014.41927 Chicago Mariusz, Jacek Daniel Bartosz Józef Kozak. 2014. "Penetrating traumas". Surgery 11 (1): Harvard...
Esophageal adenocarcinoma (ADC) incidence has been increasing dramatically in the past 3 decades despite surveillance programs patients with Barrett’s esophagus (BE). Therefore, markers of early neoplastic progression are required to predict cancer risk BE patients. The aim this study was investigate frequency Her2/neu amplification different stages during Barrett’s-related carcinogenesis.Her2/neu analysis 39 gastroesophageal reflux disease (GERD), 34 BE, 11 dysplasia and 13 ADC were...
Prognostic biomarkers are the area of high interest in non-small cell lung cancer (NSCLC). Inflammatory blood markers can be routinely determined from complete counts which inexpensive and reliable. The aim study was to determine prognostic parameters which, early diagnostics, best survival patients, operated on due NSCLC.The conducted 532 (174 females 358 males) NSCLC, stages IA - III, aged 36-84 years (the mean age: 63.6 years). following were subjected a statistical analysis, order values...
A 38-year-old man presenting expiratory stridor and high-grade dyspnoea was admitted to hospital in Lodz February 2013. Chest radiographs computed tomography scans showed a solid lesion the upper part of trachea occluding 85% airway lumen. segmental resection with subsequent end-to-end anastomosis performed. Histopathology an extracutaneous glomus tumour. There were no postoperative complications. Tracheal is primary curative method cases this rare W pracy przedstawiono przypadek mężczyzny,...
To evaluate the survival of patients after surgery esophagus/cardia using transthoracic and transhiatal methods.In years 2007-2011, 102 were radically treated for cancer esophagus/cardia: 24 women 78 men at average age 59.5. There 38 procedures 64 procedures. All had a conduit made from stomach, led through lodges in esophagus combined with stump neck following Collard method. Two-pole lymphadenectomies performed all patients.Patients statistically more (p < 0.05) lymph nodes removed than...
The development of science at the end 20(th) century introduced new surgical miniinvasive techniques. Endoscopic insertion an internal stent is alternative to other, older techniques in treatment tracheobronchial stenosis. Complications are serious and require immediate intervention. We report a case 53-year-old patient with left mainstem bronchus perforation during dynamic stent. clinical presentation was characterised by right tension pneumothorax. pleural cavity on computed tomography...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Łochowski M, Rębowski Jesionek-Kupnicka D, Kozak J. Pulmonary epithelioid hemangioendothelioma imitating lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2017;14(3):209-210. doi:10.5114/kitp.2017.70538. APA Łochowski, M., Rębowski, Jesionek-Kupnicka, D., & Kozak, (2017). Surgery, 14(3), 209-210. https://doi.org/10.5114/kitp.2017.70538 Chicago Mariusz,...
Progress in the development of surgical techniques has led to growing use video-assisted thoracoscopic surgery (VATS) mediastinal cyst treatment.To present our experience treating cysts with minimally invasive technique.Fifty patients were treated from 2001 2011. There 32 women and 18 men. The age ranged 17 72, mean being 42 years. All underwent basic preoperative diagnostic tests chest: X-ray, computed tomography (CT), bronchoscopy spirometry; 4 endobronchial ultrasound-guided...
Over 80% of patients with esophageal cancer are qualified only for palliative treatment. The main goal the therapy is to eliminate symptoms dysphagia.To analyze complications after insertion prostheses and stents in inoperable esophagus/cardia.From 1996 2015 esophagus were implanted 1309 patients. In strictures lower part esophagus, Barbin-Mousseau (102 cases) Häring (324 placed. upper middle Wilson-Cook (65 Sumi (51 using rigid oesophagoscopy. Since 2001, 867 have been...
Platelets play a vital role in the neoplastic process. Platelet parameters are hence an important source of information concerning ongoing disease. The aim study is to assess impact selected platelet on survival patients with non-small cell lung cancer (NSCLC).The included 532 (174 female and 358 male) aged 36-84 years (mean age 63.6 years) operated due NSCLC, staged IA-IIIA. Before operation, all received blood morphology test. following were subjected statistical analysis: count, mean...