Aims/Purpose: To evaluate the effectiveness of Hyperbaric Oxygen Therapy (HBOT) in improving visual acuity patients with BRAO. Methods: The Case Series analysis 3 affected by Results: In case series we described, underwent HBOT at 5, 36 and 48 hours after onset ocular symptoms. all presented cases improved quantitatively qualitatively. Conclusions: Our confirms beneficial effect on final VA an episode might be a rescue treatment early stage BRAO, particularly to time conceivable reperfusion....

The ABCB1 gene belongs to ATP binding cassette (ABC) transporter genes that has been previously implicated in cancer progression and drug response. This study aimed evaluate the association between SNP 3435 expression of lung patients Polish population comparison clinicopathological parameters treatment. 150 RNA 47 DNA samples were isolated from 49 cases including both tissue blood taken same at three time points: diagnosis, 100 days one year after surgical intervention. Qualitative...

Abstract Background The RAS family protooncogenes, including KRAS , NRAS and HRAS encode proteins responsible for the regulation of growth, differentiation survival many cell types. oncogene mutations are well defined, however, clinical significance expressions in non–small-cell lung cancer (NSCLC) is still uncertain. Methods A total 39 whole blood samples NSCLC (the investigated group), collected at three points time: time diagnosis, 100 days 1 year after surgery as 35 tissue obtained...

The aim of the study was to determine a prognostic value neutrophil lymphocyte ratio (NLR), platelet (PLR) and monocyte (LMR) ratios for survival patients, operated on due non-small cell lung cancer (NSCLC).The conducted 532 NSCLC, in stages IA-IIIA. A total 174 females 358 males, aged 36-84 years (the mean age: 63.6 years) were included study. following factors subject statistical analysis, determination potential values NLR, PLR LMR ratios: age, sex, nicotinism, number leukocytes,...

<ns3:p>Glaucoma comprises a group of disorders the optic nerve that cause degenerative neuropathy, characterised by failure neuroretinal rim tissue in head, retinal fibre layer, and ganglion cells. Glaucoma imposes serious epidemiological threat, with an steady increase global number cases. In current ophthalmological practice, glaucoma is diagnosed via series examinations, including routine funduscopic examination, ocular tonometry, gonioscopy, measurement visual field, assessment using...

The aim of the study was to determine prognostic significance PLR and NLR ratios in patients operated due non-small cell lung cancer.The group consisted 532 (174 women, 358 men) with cancer (NSCLC) staged IA-IIIA. mean age 63.6 years (range 36 84 years). Together platelet/lymphocyte ratio (PLR) neutrophil/lymphocyte (NLR), following factors were included statistical analysis: age, sex, smoking history, number leukocytes, neutrophils, platelets, histopathology, T-stage, N-stage, concomitant...

Patients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships these factors clinical variables.A total 33 patients SSc were enrolled compared 40 controls. After obtaining circular scans around disc, global quadrant (pCT) RNFL measured. Additionally,...

This study aimed to identify the biochemical parameters that determine occurrence of glaucoma and assess correlation between oxidative stress clinical data in patients with healthy controls. We enrolled 169 participants; group comprised 104 primary open-angle, pseudoexfoliation, or angle-closure glaucoma, control 65 individuals. Serum concentrations selenium (Se), copper (Cu), zinc (Zn); Cu/Zn ratio; total antioxidant status were measured both groups. Significantly lower Se Zn serum levels...

The aim of the study was to determine a survival prognostic value selected blood morphological rates patients, operated on due non-small cell lung cancer (NSCLC).The conducted 532 surgically treated NSCLC, in stages IA-IIIA, 174 females and 358 males, mean age 63.6 years (36-84 years) were included study. Blood parameters clinical factors statistical analysis, order potential values red distribution width-standard deviation (RDW-SD), corpuscular volume (MCV) hemoglobin. Factors contained:...

Purtscher-like retinopathy (PLR) is an uncommon occlusive microangiopathy associated with various systemic conditions. We report a case of PLR related to severe progressive sclerosis (SSc), autoimmune disease characterized by widespread angiopathy and fibrosis, in 44-year-old Caucasian male diagnosed early diffuse cutaneous (dSSc). Upon ophthalmological examination, pathognomonic fundoscopy abnormalities were found. Spectral domain optical coherence tomography (SD-OCT), angio-OCT, visual...

Abstract Purpose The aim of this study was to investigate choroidal parameters in patients with systemic sclerosis (SSc) using enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT) and determine their relationships clinical variables ocular features. Methods Thirty-three SSc 40 controls were enrolled. groups did not differ regard age, sex, axial length. mean thickness volume obtained each conventional Early Treatment Diabetic Retinopathy Study grid subfield....

Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics toxic compounds including (pro)carcinogens. BCRP expressed many tissues, hematopoietic stem cells. Genetic variants such as single nucleotide polymorphisms (SNPs) can change gene expression and/or reduce their products' activity which may affect individual's susceptibility...

Prognostic biomarkers are the area of high interest in non-small cell lung cancer (NSCLC). Inflammatory blood markers can be routinely determined from complete counts which inexpensive and reliable. The aim study was to determine prognostic parameters which, early diagnostics, best survival patients, operated on due NSCLC.The conducted 532 (174 females 358 males) NSCLC, stages IA - III, aged 36-84 years (the mean age: 63.6 years). following were subjected a statistical analysis, order values...

Platelets play a vital role in the neoplastic process. Platelet parameters are hence an important source of information concerning ongoing disease. The aim study is to assess impact selected platelet on survival patients with non-small cell lung cancer (NSCLC).The included 532 (174 female and 358 male) aged 36-84 years (mean age 63.6 years) operated due NSCLC, staged IA-IIIA. Before operation, all received blood morphology test. following were subjected statistical analysis: count, mean...

P-glycoprotein, product of the ABCB1 (ATP binding cassette subfamily B member 1) gene, has been reported to play an important role in multiple drug resistance during cancer therapy. However, its influence on non-small cell lung (NSCLC) risk not clearly defined. The aim present study was examine association between clinicopathological factors and SNPs T-129C, C1236T, G2677T/A, C3435T, as well haplotype, investigate polymorphisms NSCLC development. included 80 patients who suffered from...

<ns3:p>Glaucoma comprises a group of disorders the optic nerve that cause degenerative neuropathy, characterised by failure neuroretinal rim tissue in head, retinal fibre layer, and ganglion cells. Glaucoma imposes serious epidemiological threat, with an steady increase global number cases. In current ophthalmological practice, glaucoma is diagnosed via series examinations, including routine funduscopic examination, ocular tonometry, gonioscopy, measurement visual field, assessment using...

Abstract Background: The RAS family protooncogenes, including KRAS , NRAS and HRAS encode proteins responsible for the regulation of growth, differentiation survival many cell types. oncogene mutations are well defined, however, clinical significance expressions in non–small-cell lung cancer (NSCLC) is still uncertain. Methods: A total 39 whole blood samples NSCLC (the investigated group), collected at three points time: time diagnosis, 100 days one year after surgery, were included this...