The present study examines the relationship between circular RNA (circRNA) derived from three genes of family a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs): ADAMTS6, ADAMTS9 ADAMTS12 host gene expression in non-small-cell lung cancer (NSCLC) regard to various clinical factors. Notably, an association was identified specific circRNA molecules, as well certain patterns ADAMTS6 its that were histopathological subtypes. survival analysis demonstrated lower squamous...

The PI3K/AKT pathway plays a pivotal role in cellular processes, and its dysregulation is implicated various cancers, including colorectal cancer. present study correlates the expression levels of critical genes (PIK3CA, PTEN, AKT1, FOXO1, FRAP) 60 tumor tissues with clinicopathological demographic characteristics. results indicate age-related variation FOXO1 gene expression, higher observed patients aged 68 above. In addition, tumors originating from rectum exhibit compared to colon tumors,...

Alterations in the methylation of genetic material can influence carcinogenesis by downregulation or overexpression ADAMTS (a disintegrin-like and metalloprotease with thrombospondin motifs) protease genes. Through their proteolytic activity, these enzymes are also capable promoting angiogenesis. Consequently, proteases either facilitate inhibit cancer progression. This study aimed to evaluate levels ADAMTS6, ADAMTS9, ADAMTS12 genes non-small-cell lung (NSCLC) using data from bioinformatics...

Undoubtedly, mast cells take part in host defense against microorganisms as they are numerous at the portal of infection, release many proinflammatory and antimicrobial mediators, express pattern recognition receptors, such TLRs. These receptors play a key role binding molecules associated with damage. Cathelicidins exhibit direct activities broad spectrum microbes by perturbing their cell membranes. Accumulating evidence suggests for these supporting activation. We examined impact human...

The ABCB1 gene belongs to ATP binding cassette (ABC) transporter genes that has been previously implicated in cancer progression and drug response. This study aimed evaluate the association between SNP 3435 expression of lung patients Polish population comparison clinicopathological parameters treatment. 150 RNA 47 DNA samples were isolated from 49 cases including both tissue blood taken same at three time points: diagnosis, 100 days one year after surgical intervention. Qualitative...

Abstract Gastric cancer is one of the most common worldwide types cancer. It a multifactorial disease and both environmental genetic factors play an important role in its etiology. Evaluation relative expression level NFKB2 gene two groups patients: peptic ulcer gastric pathomechanism these diseases was aim this study. RNA isolated from: 79 samples ulcer, 22 11 control tissue. The real-time PCR technique used to study gene. variable all three studied groups. depends on type disease. Peptic...

In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in microenvironment, including extracellular matrix (ECM), which is not only a scaffold for cells, but also reservoir cytokines, chemokines growth factors. Metalloproteinases (MMPs) among elements that enable ECM remodeling. The publication focuses on problem gene expression MMP2, MMP9 tissue inhibitor metalloproteinases (TIMP1) blood NSCLC patients during therapy (one year after surgical...

The analysis concerned the comparison of expression membrane type matrix metalloproteinases genes in blood and tissue NSCLC patients during course disease to control group. Blood neoplastic taken from 45 diagnosed with non-small cell lung cancer was a research material. level MMP14, MMP15, MMP16 MMP24 evaluated by qPCR results were compared controls. MMP14 before tumor removal surgery 100 days after lower than Interestingly, one year levels these identical those This suggests that...

Members of the activator protein 2 (AP-2) transcription factor (TF) family are known to play a role in both physiological processes and cancer development. The comprises five DNA-binding proteins encoded by TFAP2A TFAP2E genes. Numerous scientific reports describe differential expression these TF their genes various types cancer, identifying among them potential oncogene or suppressor like TFAP2C. Other suggest influence on disease development progression, as well response treatment. Not all...

Suppressor of mothers against decapentaplegic homolog 4 (SMAD family member 4, SMAD4) is involved in the adenoma-carcinoma pathway, leading to development colon cancer. The encoded protein a key downstream signaling mediator TGFβ pathway. This pathway has tumor-suppressor functions, including cell-cycle arrest and apoptosis. Its activation late-stage cancer can promote tumorigenesis, metastasis chemoresistance. Most colorectal patients receive chemotherapy based on 5-FU as an adjuvant...

Colorectal cancer has become a serious problem, especially in highly developed countries. As reported by the World Health Organization, number of colon cases world 2012 amounted to 1.36 million. It is second most common females (614,000 cases, 9.2% total) and third males (746,000 10.0% worldwide. believed that TGFβ pathway elements are involved pathogenesis colorectal cancer. This study assessed one these elements, ACVR2A gene. Qualitative quantitative analyses gene 84 patients with was...

Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics toxic compounds including (pro)carcinogens. BCRP expressed many tissues, hematopoietic stem cells. Genetic variants such as single nucleotide polymorphisms (SNPs) can change gene expression and/or reduce their products' activity which may affect individual's susceptibility...

Major depression is the most common mental illness in world. Failures treatment may occur due to presence of a subtype called TRD (Treatment- Resistant Depression). CYP3A4 polymorphism (rs2740574) can increase activity Cytochrome P450 3A4, contributing faster metabolism xenobiotics and reduced response treatment. The aim study was assess distribution CYP3A4*1B control group estimate influence particular genotypes on parameters such as: age at onset, severity symptoms before effectiveness...

The most common mental illness is depression; however, its pathogenesis not fully understood. One of the factors that may influence development and effectiveness therapy are cytochromes p450 complex. CYP3A5 CYP2C19 involved in metabolism drugs used treatment depression. These can also generate reactive oxygen species, which known to participate aim study was determine frequency CYP3A5*3 CYP2C19*2 variants among a group patients with depression identify any potential association disease...

Colon cancer is one of the most common types malignant tumor worldwide. The molecular mechanism colorectal carcinogenesis very complex and not yet fully understood. TGFβ (transforming growth factor β) signaling pathway plays a significant role in development many cancers, including pathogenesis. Changes are associated with increased risk, because this participates control important cellular processes such as cell growth, proliferation, differentiation, or apoptosis. family SMAD (similar to...

Acute myeloid leukaemia (AML) is a heterogeneous disorder of haematopoietic stem cells or progenitor cells. Metalloproteinases (MMPs) are proteolytic enzymes whose activity increased in different types solid tumours. These regulate many processes associated with tumour progression. In haematological malignancy, the role MMPs seems to be underestimated, and only metalloproteinase 2 (MMP2) 9 (MMP9) have been widely examined so far. this work, differences 1 (MMP1) gene expression between...

Mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel monoclonal antibodies against various lymphocyte subsets and macrophages. Tumours staging groups examined in parallel patient donor peripheral blood (PBL). It was found that percentage values bearing T3 T4 phenotype reduced both tumour infiltrating (TIC) PBL population. The fall T4+ cancer patients statistically significant (p<0.01) as compared cells....

Acute myeloid leukemia is a group of hematological neoplasms characterized by heterogeneous course and high mortality. The important factor in the neoplastic process metalloproteinases, proteolytic enzymes capable degrading various components extracellular matrix, which take an active part modifying functioning cell, including transformation to cancer cell. They interact with numerous signaling pathways responsible for cell growth, proliferation, or apoptosis. In present study, changes...

Multiple myeloma is one of the most common hematological malignancies worldwide. Genetic alterations may lead to progression from monoclonal gammopathy multiple myeloma. Additionally, genetic background disease might influence therapy outcomes, including survival time. SLCO1B1, belonging OATPs family, a membrane protein that mediates uptake wide range endogenous and exogenous (including drugs) compounds.In this study, A388G single nucleotide polymorphism in SLCO1B1 gene Polish patients was...

Herein, the antitumor activity of a novel synthetic analog with 5,8-quinolinedione scaffold, diethyl (2-(2-chlorophenyl)-4,9-dioxo-4,9-dihydrofuro [3,2-g]quinolin-3-yl)phosphonate (AJ-418) was investigated on two breast cancer cell lines. This selected from small library quinolinediones basis its strong antiproliferative against MCF-7 and MDA-MB-231 cells 4-5-fold lower cytotoxicity towards healthy MCF-10A cells. The morphology treated AJ-418 changed drastically, while non-tumorigenic...

Lung cancer is the second most frequent worldwide diagnosed cancer. Mutations in RAS genes family are among common oncogenic alterations occurring non-small cell lung (NSCLC). Many treatment options against KRAS mutations have been developed for NSCLC; however, they remain insufficient. Moreover, role of and HRAS gene expression remains unclear. However, inhibitors seem to be a good candidate new drugs agents NSCLC. This study used bioinformatical analysis determine its clinical...