Abstract Antimicrobial therapy remains one of the major global challenges, particularly in absence effective treatment strategies for drug‐resistant bacteria. In this study, a comprehensive approach is proposed bacterial wound infections based on development thermal‐cascade multifunctional therapeutic systems (MTSs), spanning from design functional nanoscale materials to macroscopic smart hydrogel. Within MTSs, antibiotic‐loaded hybrid nanoclusters enable targeted delivery and synergistic...

Abstract Poor drug penetration into tumor cells and tissues is a worldwide difficulty in cancer therapy. A strategy developed for virion‐like membrane‐breaking nanoparticles (MBNs) to smoothly accomplish tumor‐activated cell‐and‐tissue dual‐penetration surmounting impermeable drug‐resistant cancer. Tailor‐made dendritic arginine‐rich peptide prodrugs are designed mimic viral protein transduction domains globular architectures. Attractively, these mimics self‐assemble aqueous solution, having...

Chemotherapy resistance remains a serious impediment to successful antitumor therapy around the world. However, existing chemotherapeutic approaches are difficult cope with notorious multidrug in clinical treatment. Herein, we developed tumor-specific multiple stimuli-activated dendrimeric nanoassemblies metabolic blockade completely combat both physiological barriers and cellular factors of resistance. With sophisticated molecular supramolecular engineering, this type nanoassembly based on...

Currently, supramolecular self-assembly of dendrons and dendrimers emerges as a powerful challenging strategy for developing sophisticated nanostructures with excellent performances. Here we report hybrid to fabricate bio-inspired dendritic system versatile delivery nanoplatform. With rational design, dual-functionalized low-generation peptide (PDs) self-assemble onto inorganic nanoparticles via coordination interactions generate multifunctional (SHDs). These SHDs exhibit well-defined...

The efficacy of photodynamic therapy (PDT) in the solid tumor is hampered by many challenges, including its oxygen self-consuming nature, insufficient levels within hypoxic microenvironment, and limited penetration photosensitizers tumors. Herein, we develop IR780@O2-SFNs/iRGD as an self-sufficient tumor-penetrating nanoplatform, which consists IR780-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs) iRGD a targeting peptide that can penetrate deeper tumor. Because high...

Abstract The tumor microenvironment is a pivotal driver of progression, highlighting the potential reversal as promising breakthrough in cancer therapy. However, current reversing capacity through targeted drug delivery remains limited, posing significant challenge biomedical field. In this study, materials science strategy to achieve an inherently efficient solid while potentiating molecular therapy efficacy against drug‐resistant tumors proposed. To construct bioactive hydrogel materials,...

A novel type of nanovehicle (NV) based on stimuli‐responsive supramolecular peptide‐amphiphiles (SPAs, dendritic poly (L‐lysine) non‐covalently linked (L‐leucine)) is developed for intracellular drug delivery. To determine the pH‐dependent mechanism, peptide‐amphiphile system (SPAS) investigated at different pH conditions using a variety physical and chemical approaches. The pH‐triggered disassembly SPAS can be attributed to disappearance non‐covalent interactions within SPAs around...

Herein, multifunctional mimics of viral architectures and infections self‐assembled from tailor‐made dendritic lipopeptides for programmed targeted drug delivery are reported. These not only have virus‐like components nanostructures, but also possess to solid tumor cells. Encouragingly, the provide following distinguished features tumor‐specific systemic delivery: i) stealthy surface resist protein interactions prolong circulation time in blood, ii) well‐defined nanostructure passive...

Abstract Bioinspired tryptophan‐rich peptide dendrimers (TRPDs) are designed as a new type of dendritic drugs for efficient tumor therapy. The TRPDs feature precise molecular structure and excellent water solubility obtained in facile process. Based on the unique features dendrimers, including highly branched structures, abundant terminal groups, globular‐protein‐like architectures, therapeutic show significant supramolecular interactions with DNA through tryptophan residues (indole rings...

Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications.We herein report a dual-responsive PEGylated system efficient platinum-based drug delivery and near-infrared (NIR) tracking.With refined molecular/supramolecular engineering, were stabilized by bioreducible disulfide bonds endowed with NIR fluorescence probes, platinum derivatives coordinated onto the abundant...

Developing novel strategies for defeating osteoporosis has become a world-wide challenge with the aging of population. In this work, supramolecular nanoagonists (NAs), constructed from alkaloids and phenolic acids, emerge as carrier-free nanotherapy efficacious treatment. These precision are formed through self-assembly berberine (BER) chlorogenic acid (CGA), utilizing noncovalent electrostatic, π–π, hydrophobic interactions. This assembly results in 100% drug loading capacity stable...

Abstract Although biomimetic virus‐like strategies have been widely used in antitumor applications, construction of uniquely shaped agents and optimization their specific morphological features to achieve diverse functions are worthwhile pursuits. Here, a novel strategy construct an artificial tobacco mosaic virus (ATMV) that closely mimics the structure rod‐like (TMV) is developed. The supramolecular array self‐assembled from small, repeated subunits tailor‐made capsid‐mimicking dendrons...

The rising incidence of bacterial infections poses a significant challenge to global public health. development safe and effective antibacterial treatment strategies is an urgent need in the field biomedicine. In this work, we developed smart nanoparticle-hydrogel platform address wounds. Rifampicin-loaded chitosan-functionalized nanoparticles (R-CNP) could break barriers enhance antibiotic internalization. R-CNP reduced minimum inhibitory concentration rifampicin against Staphylococcus...

Abstract Novel nonviral gene vectors of alkaline amino acids such as arginine‐ (Arg), histidine‐ (His), and lysine‐ (Lys) modified chitosans (AAA‐CSs) are developed to simulate the components viral envelopes enhance transfection efficiency. The structures characterized using 1 H NMR spectroscopy. Acid‐base titration results indicate that exhibit strong buffering capacity. morphology AAA‐CSs/pDNA complexes is observed by use transmission electron microscopy atomic force microscopy. spherical...

Cationic lipid based assemblies provide a promising platform for effective gene condensation into nanosized particles, and the peripheral properties of are vital complexation interaction with physical barriers. Here, we report three cationic twin head lipids, each them contains dioleoyl-glutamate hydrophobic tail polar lysine, arginine, or histidine. Such lipids were proven to self-assemble in aqueous solution well-defined nanostructures residual amino-, guanidine-, imidazole-rich periphery,...

In this paper, π–π conjugated cinnamic acid (CIN) was used as a lipophilic moiety to fabricate polymeric micelles. The amphiphiles with one or two molecules architectures (mPEG–CIN and mPEG–Lys–DCIN) were synthesized. We expressly investigated the effect of parts on size, morphology stability self-assembly Anticancer drug doxorubicin (DOX) trapped in micelles interactions between moieties DOX studied. anticancer activity DOX-loaded evaluated both vitro vivo. results revealed that...

With inspirations from natural viruses, arginine-containing dendritic lipopeptides were designed for bioinspired fabrication. Self-assembling the defined amphiphilic generated virus-inspired nanovectors with an arginine-rich corona. These provided some remarkable benefits gene delivery, including well-defined nanostructure, high transfection efficiency, serum resistance and low cytotoxicity.

The stability dilemma and limited tumor penetration of nanocarriers in cancer chemotherapy remain two predominant challenges for their successful clinical translation. Herein, the pH-sensitive fluorocarbon-functionalized (SFNs) with a tumor-homing penetrating peptide iRGD are reported to overcome enhance accumulation an orthotopic breast cancer. highly stable SFNs low critical association concentration provide safe spacious harbor hydrophobic drugs. Furthermore, stimulus-responsive...

Herein, smart Au nanorod@dendrimer-assembly nanohybrids (AuNR@DA NHs) were developed for adapting sequential biological barriers and remodeling tumor permeability, thereby achieving multimodal enhancement of penetration internalization in multidrug-resistant poorly-permeable tumors.

We developed a biocompatible triple-responsive dendrimeric nanocage (TDN) through simple method for targeted drug delivery.