A5040390713- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Virus-based gene therapy research
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- 14-3-3 protein interactions
- Gastric Cancer Management and Outcomes
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Inhalation and Respiratory Drug Delivery
- Glycosylation and Glycoproteins Research
- Cutaneous lymphoproliferative disorders research
- Antimicrobial agents and applications
- Chromatin Remodeling and Cancer
- Lung Cancer Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Phytochemistry and Bioactive Compounds
- Cancer, Hypoxia, and Metabolism
Sichuan University
2024
West China Hospital of Sichuan University
2024
Hunan University
2021-2024
New York University
2022-2024
Northwest A&F University
2023
Xinjiang Institute of Ecology and Geography
2021
Northwest Institute of Plateau Biology
2021
University of Chinese Academy of Sciences
2021
Abstract Antimicrobial therapy remains one of the major global challenges, particularly in absence effective treatment strategies for drug‐resistant bacteria. In this study, a comprehensive approach is proposed bacterial wound infections based on development thermal‐cascade multifunctional therapeutic systems (MTSs), spanning from design functional nanoscale materials to macroscopic smart hydrogel. Within MTSs, antibiotic‐loaded hybrid nanoclusters enable targeted delivery and synergistic...
Abstract The tumor microenvironment is a pivotal driver of progression, highlighting the potential reversal as promising breakthrough in cancer therapy. However, current reversing capacity through targeted drug delivery remains limited, posing significant challenge biomedical field. In this study, materials science strategy to achieve an inherently efficient solid while potentiating molecular therapy efficacy against drug‐resistant tumors proposed. To construct bioactive hydrogel materials,...
How to break through the poor response of current drug therapy, which often resulted from tumor microenvironment heterogeneity (TMH), remains an enormous challenge in treatment critical diseases. In this work, a practical solution on bio-responsive dual-drug conjugates for overcoming TMH and improving antitumor treatment, integrates advantages macromolecular drugs small-molecular drugs, is proposed. Nanoparticulate prodrugs based are designed as robust weapon programmable multidrug delivery...
Synthesizing biomimetic systems with stereospecific architectures and advanced bioactivity remains an enormous challenge in modern science. To fundamentally eliminate biosafety issues of natural oncolytic viruses, the development synthetic virus-inspired particles high activity is urgently needed for clinical antitumor treatments. Here, we describe design synthesis enantiomeric efficient therapy from homochiral building blocks to supramolecular constructions. The L-virus-inspired (L-VOPs)...
Malignant tumors represent a formidable global health challenge, compelling the pursuit of innovative treatment modalities. Oncolytic therapy has emerged as promising frontier in antitumor strategies. However, both natural agents (such oncolytic bacteria or viruses) and synthetic peptides confront obstacles clinical trials, which include delicate equilibrium between safety efficacy, imperative for systemic administration with targeted therapy, need to counteract oncolysis-induced...
Although there have been studies correlating DYRK2 with a number of human cancers, has no pan-cancer analysis. Therefore, through the TCGA database, we conducted related study on expression in cancers.The is obviously increased some while opposite true others, and clear association between its prognosis cancer patients.The mutation also significantly correlated patients' certain tumors. In addition, phosphorylation methylation levels are different tumor tissues adjacent normal various tumour...
A new triterpenoid saponin, 3-O-β-D-allopyranosyl (1→3)-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl (1→4)-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl ester (IV), together with six known ones Hederacholichiside F (I), Tanguticoside B (II), Tauroside St-H1 (III), Hederoside H1 (V), Kalopanaxsaponin G (VI), Hederasaponin (VII) were separated from Clematis tangutica (Maxim.) Korsh. Their cytotoxic activities evaluated. Saponins IV (new compound) and I...
Virus-mimetic nanocapsules are developed for mimicking tumor-targeted infection and improving protein systemic delivery through bioinspired macromolecular supramolecular engineering.
Abstract Aberrant N-linked glycosylation is a prominent feature of cancers. Perturbance oligosaccharide structure on cell surfaces directly affects key processes in tumor development and progression. In spite the critical role played by glycans biology, discovery small molecules that specifically disturbs still under investigation. To identify more saccharide-structure-perturbing compounds, repurposed drug screen using library consisting 1530 FDA-approved drugs was performed. Interestingly,...
Nanoparticulate Prodrugs In article number 2301656, Xianghui Xu and co-workers present nanoparticulate prodrugs based on bio-responsive macromolecular drug small-molecular conjugates for tumor microenvironment heterogeneity management therapeutic response enhancement. This nanomedicine strategy achieves site-specific delivery of drugs within tissues, providing efficient extracellular matrix, interstitial pressure, vascular network, blood flow, hypoxia.
Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy of skin, and its incidence increasing annually. Once cSCC becomes metastatic, associated mortality rate much higher than that in situ. However, current treatments for progressive have several limitations. The aim this study was to suggest a potential compound future research may benefit patients with cSCC. Methods: In study, we screened following differentially expressed genes from Gene Expression...
<p>(a) Western blot analysis of protein expression pattern PD-L1 in HEK293T cells after the exposure to indicated concentrations penfluridol for 24 hours. (b) Protein B16-F10 treatment with 12 hours as determined by western blot. (c) The toxicity effect on (top) and B16-OVA (bottom) cells. (d) MAN1A1 treated siRNA.</p>
<p>(a) The stability of proteins was determined by cellular thermal shift at different concentrations penfluridol.</p>
<p>Supplementary Figure S1-S4 Supplementary Table S1</p>
<p>Supplementary Figure S1-S4 Supplementary Table S1</p>
<p>(a) Western blot analysis of glycoprotein patterns in MDA-MB-231 cells after treatment with the indicated concentrations penfluridol for 24 hours. Red arrowhead, immature glycoproteins. (b) protein expression pattern ACE2 HEK293T (c) In cells, FLAG-tagged was treated hours, collected by immunoprecipitation, subjected to SDS-PAGE, and analyzed western blot. (d) Pearson correlation coefficient three independent groups through N-glycan profiling.</p>
<p>(a) The stability of proteins was determined by cellular thermal shift at different concentrations penfluridol.</p>
<div>Abstract<p>Aberrant N-linked glycosylation is a prominent feature of cancers. Perturbance oligosaccharide structure on cell surfaces directly affects key processes in tumor development and progression. In spite the critical role played by glycans biology, discovery small molecules that specifically disturbs still under investigation. To identify more saccharide-structure-perturbing compounds, repurposed drug screen using library consisting 1530 FDA-approved drugs was...
<div>Abstract<p>Aberrant N-linked glycosylation is a prominent feature of cancers. Perturbance oligosaccharide structure on cell surfaces directly affects key processes in tumor development and progression. In spite the critical role played by glycans biology, discovery small molecules that specifically disturbs still under investigation. To identify more saccharide-structure-perturbing compounds, repurposed drug screen using library consisting 1530 FDA-approved drugs was...
<p>(a) Western blot analysis of protein expression pattern PD-L1 in HEK293T cells after the exposure to indicated concentrations penfluridol for 24 hours. (b) Protein B16-F10 treatment with 12 hours as determined by western blot. (c) The toxicity effect on (top) and B16-OVA (bottom) cells. (d) MAN1A1 treated siRNA.</p>
<p>(a) qPCR analysis of the GRP78 and CHOP expression in MDA-MB-231 cells after treatment with indicated concentrations for 6 hours. (b) Western blot Integrin β1 pattern drugs 24 (c) protein treated siRNA.</p>
<p>(a) Western blot analysis of glycoprotein patterns in MDA-MB-231 cells after treatment with the indicated concentrations penfluridol for 24 hours. Red arrowhead, immature glycoproteins. (b) protein expression pattern ACE2 HEK293T (c) In cells, FLAG-tagged was treated hours, collected by immunoprecipitation, subjected to SDS-PAGE, and analyzed western blot. (d) Pearson correlation coefficient three independent groups through N-glycan profiling.</p>
<p>(a) qPCR analysis of the GRP78 and CHOP expression in MDA-MB-231 cells after treatment with indicated concentrations for 6 hours. (b) Western blot Integrin β1 pattern drugs 24 (c) protein treated siRNA.</p>
Despite the widespread adoption of video-assisted thoracoscopic surgery (VATS) for major lung resection, 10-year long-term survival outcomes non-small cell cancer (NSCLC) treated with VATS compared open resection is lacking. The purpose this study was to analyze short- and