A5101820115- Phytochemistry and Bioactivity Studies
- Saffron Plant Research Studies
- Reproductive biology and impacts on aquatic species
- Hedgehog Signaling Pathway Studies
- Phytochemistry and Biological Activities
- Selenium in Biological Systems
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Extracellular vesicles in disease
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Machine Learning in Bioinformatics
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Coding theory and cryptography
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Risks and Factors
- Proteoglycans and glycosaminoglycans research
- Cancer-related gene regulation
Jiangsu Cancer Hospital
2024
Fujian Medical University
2016-2021
Zhumadian Central Hospital
2015-2021
Fujian Provincial Cancer Hospital
2021
Third Xiangya Hospital
2020
Central South University
2020
Sichuan Agricultural University
2020
Affiliated Hospital of Guizhou Medical University
2016
Guiyang Medical University
2016
Abstract Background Metabolic syndrome (MetS) has been suggested to be a risk factor for many cancers, including breast cancer. However, it remains unclear whether MetS predicts poor prognosis in women with A meta-analysis was performed summarize the association between and clinical outcome Methods Cohort studies were identified by search of PubMed Embase databases. random-effect model incorporating potential heterogeneity applied pool results. Subgroup analyses according ethnicity study...
A subcellular organelle-targeted delivery of anti-cancer drugs is a promising strategy to maximize the effects and minimize adverse effects. Herein, we prepared mitochondria-targeted drug nanoplatform based on IR780 iodide (IR780) titanium disulfide (TiS2) nanosheets. Due large specific surface area TiS2 nanosheets, could highly load resveratrol (RV). The as-prepared nanocomposite (IR780-TiS2/RV) was used for an efficacious photothermal-triggered tumor chemotherapy. IR780-TiS2/RV showed...
Abstract Distant metastasis is the primary failure pattern of nasopharyngeal carcinoma(NPC) in intensity-modulated radiation therapy(IMRT) era. This study was conducted to find impact genetic variations phosphatidylinositol 3-kinase(PI3K)/phosphatase and tensin homologue(PTEN)/v-akt murine thymoma viral oncogene homologue(AKT)/mammalian target rapamycin(mTOR) pathway on risk distant NPC. We genotyped 16 single-nucleotide polymorphisms(SNPs) five core genes this from 496 patients treated by...
Tyrosine kinase inhibitors (TKI)-resistant mutation in epidermal growth factor receptor's (EGFR) domain is an important anomaly to look into. Studying the mutations at atomic level using molecular dynamics simulations gave us insight into architectural changes happening microscopic level. The knowledge was used design new TKI whose function devoid of affect domain. Traditional Chinese medicinal library for structure-based drug designing, where virtual screening followed by ADME/Tox analysis...
Polysaccharides from Bergenia emeiensis (PBE) showed a robust antioxidant ability on scavenging free radicals in vitro. However, the further potential cell level and vivo was still unknown. Therefore, this present study, protective effect of PBE human cervical carcinoma (Hela) cells Caenorhabditis elegans against oxidative stress evaluated. The results could reduce reactive oxygen species (ROS) Hela promote mitochondrial membrane potential. Then, apoptosis reduced. Moreover, enhance survival...
Abstract Gastric cancer (GC) is the fifth most common worldwide and one of aggressive cancers in China. Glypican 6 highly expressed gastric adenocarcinoma may act as a diagnostic prognostic marker; however, functional importance molecular mechanism glypican GC remains unclear. In current study, we aimed to reveal function two cell lines: MKN-45 SGC-7901. We found higher expression SGC-7901 cells than from normal mucosa epithelial line GES-1. knockdown suppressed proliferation. A Transwell...
is a traditional herb in Chinese folk medicine. Most related studies are focused on the bioactivity of bergenin, neglecting other bioactive compounds. In our previous work, polysaccharides were identified
This study was the first designed to evaluate extraction and antioxidant ability of triterpenes from Bergenia emeiensis rhizomes. The yield B. mainly affected by concentration ethanol, followed time, solvent sample ratio, power ultrasound. Thus, response surface method applied investigate interaction between two factors optimize process. optimal conditions were 210 W, 75% 40 min 25 mL/g with a maximum 229.37 ± 7.16 mg UAE/g. Moreover, (TBE) evaluated determining scavenging capacity on free...
URG4, a novel oncogene, is involved in the development and progression of various tumors. This study investigated clinicopathological significance URG4 nasopharyngeal carcinoma (NPC). We used five NPC tissues adjacent normal to determine expression found that was upregulated tissues. Immunohistochemistry analysis expressed positively 97.1% (99/102) samples highly 41.2% (42/102) samples. Its level correlated with advancing clinical stage. Kaplan-Meier log-rank test patients high had poor...
Abstract Turbo codes play a crucial role in wireless communication systems, and their compiled code structures are key factors affecting the performance of entire system. As result, study turbo has been focal point for researchers. The iterative decoding multiple limitations large storage resource consumption, leading to poor system anti‐interference ability rapid increase BER. To address these issues, this paper proposes mimic structure (MTCCS) systems. MTCCS is based on DHR idea,...
The eukaryotic cell nucleus, once believed to contain structureless nucleoplasm surrounding chromatin and the nucleolus is now thought an extensive nucleoskeletal matrix on which chromatin, RNP a complex array of transcription factors, hormone receptors other regulatory factors are spatially arranged. A distinct nucleoskeleton has been difficult identify in intact due part masking by dense fibers. However, if extracted nuclease digestion high salt, underlying anastomosing network 9-13 nm...