A5085889938- Radiopharmaceutical Chemistry and Applications
- Chemical Synthesis and Analysis
- Catalytic Processes in Materials Science
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Amino Acid Enzymes and Metabolism
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Alcohol Consumption and Health Effects
- Synthesis of heterocyclic compounds
- Catalysis and Oxidation Reactions
- Chemical Synthesis and Reactions
- Liver Disease Diagnosis and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Metal complexes synthesis and properties
- Hepatitis B Virus Studies
- Crystal structures of chemical compounds
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Advanced Photocatalysis Techniques
- Blood Pressure and Hypertension Studies
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
Dalian Medical University
2018-2025
Second Affiliated Hospital of Dalian Medical University
2020-2025
King's College London
2015-2025
Guangzhou University of Chinese Medicine
2025
Laboratoire d’Imagerie Biomédicale
2025
Columbia University
2024
Guizhou Provincial People's Hospital
2008-2024
China Pharmaceutical University
2024
University of Electronic Science and Technology of China
2023
Harvard University
2023
Abstract Insufficient drug loading and leakage of payload remain major challenges in designing liposome-based delivery systems. These phenomena can limit duration effect cause toxicity. Targeting the rate-limiting step release from liposomes, we modify (aromatized) them to have aromatic groups within their lipid bilayers. Aromatized liposomes are designed with synthetic phospholipids covalently conjugated onto acyl chains. The optimized aromatized liposome increases significantly decreases...
Abstract Background The connection between lipid-related obesity indices and severe headache or migraine in young middle-aged people aged 20–60 remains ambiguous, there are gaps the discriminative ability of different indicators for headaches migraines. Consequently, we set out to look into this association utilizing National Health Nutrition Examination Survey (NHANES) data from 1999 2004. Methods After values waist-to-height ratio (WHtR), body-mass index (BMI), body roundness (BRI),...
Nuclear imaging in conjunction with radioactive tracers enables noninvasive measurements of biochemical events vivo. However, access to remains limited due the lack methods for rapid assembly radiolabeled molecules prerequisite biological activity. Herein, we report a one-pot, three-component, copper(II)-mediated reaction azides, alkynes, and [(125)I]iodide yield 5-[(125)I]iodo-1,2,3-triazoles. Using selection azides alkynes combinatorial approach, have synthesized library structurally...
microRNAs play an important role in the progression of hepatocellular carcinoma (HCC). In this study, we found that miR-582-5p expression was downregulated hepatoma tissues and HCC cell lines. Upregulation reduced colony number, inhibited cellular proliferation, arrested cycle G0/G1 phase. When inhibited, number increased proliferation were promoted. Further studies showed regulated through directly inhibiting CDK1 AKT3, indirectly cyclinD1.
Designing a targeted and versatile photothermal agent for the integration of precise diagnosis effective treatment tumors is desirable but remains great challenge. In this study, folic acid ligand conjugated lipid-coated polyaniline hybrid nanoparticles (FA-Lipid-PANI NPs) were successfully fabricated by distinctive technology. The obtained FA-Lipid-PANI NPs with small size exhibited not only significant photoacoustic (PA) imaging signals, also remarkable effect tumor treatment. With PA...
Myocardial hypoxia is an attractive target for diagnostic and prognostic imaging, but current approaches are insufficiently sensitive clinical use. The PET tracer copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (<sup>64</sup>Cu-ATSM) has promise, its selectivity sensitivity could be improved by structural modification. We have therefore evaluated a range of <sup>64</sup>Cu-ATSM analogs imaging hypoxic myocardium. <b>Methods:</b> Isolated rat hearts (<i>n</i> = 5/group) were perfused with...
Cu-containing zeolites are often synthesized by two methods: ion exchange or one-pot synthesis. The former contains zeolite synthesis and in steps. For the latter method, of Cu based is more convenient. However, content very difficult to control. In this work, we developed a facile dual-template strategy design synthesize Cu-ZSM-5-D catalysts order achieve better ammonia selective catalytic reduction (NH3-SCR) performance, compared with Cu/ZSM-5 via traditional method. Furthermore, directly...
Alcoholic liver disease (ALD) is one of the main causes death in chronic disease. Oxidative stress and pyroptosis are important factors leading to ALD. Bromodomain-containing protein 4 (BRD4) a factor that we have confirmed regulate As phenolic acid compound, sinapic (SA) has significant effects antioxidant, anti-inflammatory protection. In this study, explored whether SA regulates oxidative through BRD4 play protective effect Male C57BL/6 mice AML-12 cells were used for experiments. We...
Abstract: Liposomal nanoparticles are versatile drug delivery vehicles that show great promise in cancer therapy. In an effort to quantitatively measure their vivo pharmacokinetics, we developed a highly efficient 89 Zr liposome-labeling method based on rapid ligand exchange reaction between the membrane-permeable Zr(8-hydroxyquinolinate)4 complex and hydrophilic liposomal cavity-encapsulated deferoxamine (DFO). This novel Zr-labeling strategy allowed us prepare radiolabeled forms of folic...
Notoginsenoside R1 (NGR1), the primary bioactive compound found in Panax notoginseng, is believed to have antihypertrophic and antiapoptotic properties, has long been used prevent treat cardiovascular diseases. However, its potential role prevention of diabetic cardiomyopathy remains unclear. The present study aimed investigate mechanism NGR1 action high glucose-induced cell injury. H9c2 cardiomyocytes were cultured a high-glucose medium as an in-vitro model, apoptotic cells visualized using...
A highly efficient and rapid CuII-mediated three-component "click reaction" allows one-pot assembly of dual optical nuclear labeling reagents. Proof-of-concept imaging studies demonstrate that the distribution dual-labeled antibody A5B7 can be interrogated from cellular to macroscopic level using a combination techniques. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
A novel selectively targeting gene delivery approach has been developed for advanced hepatocellular carcinoma (HCC), a leading cause of cancer mortality whose prognosis remains poor. We combine the strong liver tropism serotype-8 capsid-pseudotyped adeno-associated viral vectors (AAV8) with liver-specific promoter (HLP) and microRNA-122a (miR-122a)-mediated posttranscriptional regulation. Systemic administration our AAV8 construct resulted in preferential transduction encouragingly HCC at...
It is observed the crystal water in sodium thiosulfate pentahydrate (Na2S2O3·5H2O) can promote its multicomponent reaction with heteroaryl chlorides and alcohols, providing a facile, green, specific synthesis of unsymmetrical thioethers via one-step formation two C-S bonds under catalyst-, additive-, solvent-free conditions. Mechanistic studies suggest that Na2S2O3·5H2O crucial generating key thiol intermediates byproduct NaHSO4, which then catalyzes dehydrative substitution alcohols thiols...
Abstract Background and Purpose Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B‐cell receptor‐associated protein 31 (BAP31) can regulate ER homeostasis anti‐apoptosis, but the function regulation of BAP31 ALD are unclear. The purpose this study to investigate whether deacetylation by sirtuin 2 could attenuate apoptosis during explore carnosol alleviate through 2/BAP31 pathway. Experimental Approach A mouse model was established feeding...
4-[18F]-Fluorophenylglyoxal ([18F]-FPG) is a novel arginine selective bioconjugation reagent for native protein 18F-labeling. Here, we report the automated radiosynthesis of [18F]-FPG on Scintomics GRP module. The radiochemical preparation was performed in one-pot, two-step process using DMSO-resistant cassette system. A cartridge-based purification method developed to purify without HPLC. prepared nondecay corrected (n.d.c.) yields (RCYs) 27 ± 2% (n = 5) 56 min from end bombardment until...