A5037353254- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Treatment and Research
- Axon Guidance and Neuronal Signaling
- Sulfur Compounds in Biology
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- Wnt/β-catenin signaling in development and cancer
- Hedgehog Signaling Pathway Studies
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Glutathione Transferases and Polymorphisms
- Hippo pathway signaling and YAP/TAZ
- Genomics and Chromatin Dynamics
- Adipose Tissue and Metabolism
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
- Advanced Glycation End Products research
ShanghaiTech University
2018-2022
Chinese Academy of Sciences
2019-2021
Center for Excellence in Molecular Cell Science
2019-2021
University of Chinese Academy of Sciences
2019-2021
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a small percentage patients show response to ICI, and there an unmet need for biomarkers that will identify who are more likely respond immunotherapy. The fundamental basis ICI immunogenicity tumor, which primarily determined tumor antigenicity antigen presentation efficiency. Here, we propose method measure score (TIGS), combines mutational burden (TMB) expression...
Non-small cell lung cancer (NSCLC) is known to carry heavy mutation load. Besides smoking, cytidine deaminase APOBEC3B plays a key role in the process of NSCLC. also reported be upregulated and predicts bad prognosis However, targeting high NSCLC still big challenge. Here we show that upregulation significantly associated with immune gene expression, expression positively correlates immunotherapy response biomarkers, including: PD-L1 T-cell infiltration Importantly, APOBEC mutational...
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures single base substitution (SBS) have been extensively studied in different types Copy number alterations are important drivers for progression multiple However, practical tools studying copy still lacking. Here, a user-friendly open source bioinformatics tool "sigminer" has constructed signature extraction, analysis and visualization....
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a fraction patients show response to ICI, and there an unmet need for biomarkers that will identify more likely respond ICI. Here we report ICI prediction biomarker tumor mutational burden (TMB) shows significant sex differences. TMB's predictive power significantly better female than male lung cancer patients. Receiver operating characteristic curve analysis was performed...
Hypoxia, a hallmark of solid tumors, promotes the malignant progression and is challenging to target. Metabolic reprogramming resulting metabolic vulnerabilities provide promising strategy target tumor hypoxia. Here we systematically compared network differences between hypoxic non-hypoxic cells, developed deep learning model, "DepFormer", predict dependent genes in cells. The performance DepFormer was validated using CRISPR screening dataset. Oxidative phosphorylation identified as most...
How cells adapt to oncogenic transformation-associated cellular stress and become fully transformed is still unknown. Here we identified a novel GGCT-regulated glutathione (GSH)-reactive oxygen species (ROS) metabolic pathway in alleviation. We GGCT as target of Ras that it required for Ras-induced primary mouse cell proliferation transformation vivo lung cancer formation the LSL-Kras G12D model. However, deficiency compatible with normal development, suggesting can be cancer-specific...
Lymph nodes metastases are common in patients with lung cancer. Additionally, those often at a higher risk for death from tumor than tumor-free lymph nodes. Somatic DNA alterations key drivers of cancer, and copy number (CNAs) major types alteration that promote cancer progression. Here, we performed genome-wide analysis, identified novel lung-cancer-metastasis-related gene, EFNA4. The EFNA4 genome locus was significantly amplified, mRNA expression up-regulated compared normal tissue, also...
Abstract Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures single base substitution (SBS) have been extensively studied in different types cancer, however, cancer genome copy number (CNA) are still elusive most types, especially prostate (PC), which is particularly driven complex alterations. Here, a user-friendly open source bioinformatics tool “sigminer” has constructed for...
Noncoding DNA sequences occupy more than 98% of the human genome; however, few cancer noncoding drivers have been identified compared with coding drivers, probably because a distinct mutation pattern due to function DNA. Here we performed pan-cancer whole genome analysis screen for functional mutations that influence protein factor binding. Recurrent were in promoter CDC20 gene. These hotspot disrupt binding ELK4 transcription repressor, lead up-regulation transcription. Physiologically...
Summary The expression of GGCT (γ‐glutamyl cyclotransferase) is upregulated in various human cancers. γ‐glutamyl cyclotransferase enzyme activity was originally purified from red blood cells (RBCs), but the physiological function RBCs still not clear. Here we reported that Ggct deletion mice leads to splenomegaly and progressive anaemia phenotypes, due elevated oxidative damage shortened life span −/− RBCs. have increased reactive oxygen species (ROS), are more sensitive H 2 O ‐induced...
Abstract Lymph nodes metastases are common in patients with lung cancer. And those often at a higher risk for death from tumor than tumor-free lymph nodes. So-matic DNA alterations key drivers of cancer, and copy number (CNAs) major type alteration that promotes cancer progression. Here, we performed genome-wide analysis, identified novel metastasis related gene, EFNA4. EFNA4 genome locus was significantly amplified mRNA expression up-regulated compared normal tissue, also node without...
Abstract This study is arising from Van den Eynden J. et al. Nature Genetics. Lack of detectable neoantigen depletion signals in the untreated cancer genome. tried to address a very important scientific question: could immune system eliminate cells with immunogenic mutations situation? first annotated human exome into “HLA-binding regions” and “non HLA-binding based on predicted binding affinity nonapeptides translated un-mutated reference coding genome type I HLA alleles. They hypothesized...
Abstract GGCT encodes γ-glutamyl cyclotransferase enzyme activity, and its expression is up-regulated in various human cancers. activity was originally purified from red blood cells (RBCs), however physiological function of RBCs still not clear. Here we reported that Ggct deletion mouse leads to splenomegaly progressive anemia phenotypes, due elevated oxidative damage shortened life span −/− RBCs. have increased reactive oxygen species (ROS), are more sensitive H 2 O induced compared control...