A5100410843- Cancer Genomics and Diagnostics
- Plant Toxicity and Pharmacological Properties
- Cancer Immunotherapy and Biomarkers
- Plant-based Medicinal Research
- Acute Lymphoblastic Leukemia research
- Amino Acid Enzymes and Metabolism
- Chromatography in Natural Products
- Plant and Fungal Species Descriptions
- vaccines and immunoinformatics approaches
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Enzyme Structure and Function
- Endoplasmic Reticulum Stress and Disease
- Prostate Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Livestock and Poultry Management
- T-cell and B-cell Immunology
- Polysaccharides and Plant Cell Walls
- Plant Parasitism and Resistance
- Genomics and Chromatin Dynamics
- Phytochemistry and Biological Activities
- RNA and protein synthesis mechanisms
- Catalysis and Hydrodesulfurization Studies
- Digestive system and related health
- Ethnobotanical and Medicinal Plants Studies
Second Affiliated Hospital of Nanjing Medical University
2024
Nanjing Medical University
2024
ShanghaiTech University
2019-2023
Chinese Academy of Sciences
2015-2021
University of Chinese Academy of Sciences
2018-2021
Center for Excellence in Molecular Cell Science
2019-2021
Shandong Academy of Agricultural Sciences
2021
Poultry Research Institute
2021
Beijing Botanical Garden
2018-2019
South China Botanical Garden
2018-2019
Immunotherapy, represented by immune checkpoint inhibitors (ICI), is transforming the treatment of cancer. However, only a small percentage patients show response to ICI, and there an unmet need for biomarkers that will identify who are more likely respond immunotherapy. The fundamental basis ICI immunogenicity tumor, which primarily determined tumor antigenicity antigen presentation efficiency. Here, we propose method measure score (TIGS), combines mutational burden (TMB) expression...
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures single base substitution (SBS) have been extensively studied in different types Copy number alterations are important drivers for progression multiple However, practical tools studying copy still lacking. Here, a user-friendly open source bioinformatics tool "sigminer" has constructed signature extraction, analysis and visualization....
Arabinogalactan proteins (AGPs) are a family of extracellular glycoproteins implicated in plant growth and development. With rapid the number genomes sequenced many species, members AGPs can now be predicted to facilitate functional investigation. Building upon previous advances identifying Arabidopsis AGPs, an integrated strategy systematical AGP screening for "classical" "chimeric" is proposed this study. A Python script named Finding-AGP compiled find AGP-like sequences filter candidates...
Abstract Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose polymerase (PARP) inhibitors well platinum chemotherapy drugs applied HRD patients. However, it remains a challenge predict status precisely economically. Copy number alteration (CNA), pervasive trait human cancers, can be extracted from variety data sources, including whole...
Chicken body size (BS) is an economically important trait, which has been assessed in many studies for genetic selection. However, previous reports detected functional chromosome mutations or regions using gene chips. The present study used the specific-locus amplified fragment sequencing (SLAF-seq) technology to perform a genome-wide association (GWAS) of purebred Wenshang Barred chickens. A total 250 one-day-old male chickens were this study. Body individual birds was measured at 56 days....
Abstract Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures single base substitution (SBS) have been extensively studied in different types cancer, however, cancer genome copy number (CNA) are still elusive most types, especially prostate (PC), which is particularly driven complex alterations. Here, a user-friendly open source bioinformatics tool “sigminer” has constructed for...
Noncoding DNA sequences occupy more than 98% of the human genome; however, few cancer noncoding drivers have been identified compared with coding drivers, probably because a distinct mutation pattern due to function DNA. Here we performed pan-cancer whole genome analysis screen for functional mutations that influence protein factor binding. Recurrent were in promoter CDC20 gene. These hotspot disrupt binding ELK4 transcription repressor, lead up-regulation transcription. Physiologically...
A new natural hybrid, Sphagneticola × guangdongensis (Asteraceae, Heliantheae), is described and illustrated. Its chromosome number was revealed to be 2n = 53, lending strong support for its hybridity parental origin (S. calendulacea with 50 S. trilobata 56) as previously already confirmed by evidence from morphology molecular data.
Highlights•Existing markers (MRD, cytogenetics, omics) in pediatric ALL faced standardization challenges.•Study innovatively translated non-coding biomarkers (miRNAs, circRNAs) into a blood-based, noninvasive relapse detection assay.•High-throughput chip tech identified promising panel of three miRNAs and circRNAs for predictive potential.•Validation training larger cohorts confirmed the accuracy, outperforming individual risk stratification.•Integration RNAs with clinical data marks...
Abstract This study is arising from Van den Eynden J. et al. Nature Genetics. Lack of detectable neoantigen depletion signals in the untreated cancer genome. tried to address a very important scientific question: could immune system eliminate cells with immunogenic mutations situation? first annotated human exome into “HLA-binding regions” and “non HLA-binding based on predicted binding affinity nonapeptides translated un-mutated reference coding genome type I HLA alleles. They hypothesized...
Senecio karelinioides (Asteraceae−Senecioneae) is a species with rather distinctive habit and an uncertain position in the genus. Based on evidence from macro‐ micro‐morphology, karyology ITS ETS sequence data, we demonstrate that it actually member of Synotis closely related to atractylidifolia . The relationship further supported by approximately unbiased Swofford–Olsen–Waddell–Hillis statistical topology tests. We thus transfer as place same section S. sect. Karelinioidei recombined for...
Cissampelopsis quinquesquamata (Asteraceae–Senecioneae), a new species from western Myanmar and northeastern India is described illustrated. It differs all except C. ansteadii in having involucres of 5 (vs 8 or 13) phyllaries 8–28) florets. From , it distinguished by glabrous subglabrous leaves densely white‐arachnoid‐tomentose beneath). Based on discoid capitula, placed C . sect.
Arnica, the only genus within subtribe Arnicinae under tribe Madieae of Asteraceae, is a circumboreal 29 species mainly distributed in western North America, with few Europe and Asia. Here we report occurrence China for first time. A population Arnica angustifolia subsp. was discovered Qinghe County, Xinjiang. Our identification confirmed by evidence from ITS/ETS sequence data.
Delphinium aktoense, D. kaschgaricum, kunlunshanicum, wuqiaense and zhangii (Ranunculaceae) were all described from the region of eastern Pamir-western Kunlun Shan in western Xinjiang, China. Critical observations on both herbarium specimens (including type material) living plants demonstrate that they are indistinguishable each other conspecific with afghanicum, a species previously known only Afghanistan.
Delphinium ellipticovatum, D. tianshanicum and winklerianum (Ranunculaceae) share some important characters in leaf division, pedicel pubescence the shape of spur upper sepals. They have been considered to be different mainly bracteoles (shape, size, indumentum, position on pedicels). Our critical observations herbarium specimens (including type material) living plants, together with numerical analyses bracteole within between populations species question, demonstrated that, addition kuanii...