A5100404551- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Sperm and Testicular Function
- Protease and Inhibitor Mechanisms
- Chromatin Remodeling and Cancer
- Reproductive Biology and Fertility
- Histone Deacetylase Inhibitors Research
- S100 Proteins and Annexins
- Hormonal and reproductive studies
- Signaling Pathways in Disease
- Caveolin-1 and cellular processes
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
Sun Yat-sen University
2009-2023
Shanxi Medical University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Shandong University
2014-2023
Northwest A&F University
2023
Dalian Medical University
2022
First Affiliated Hospital of Dalian Medical University
2022
University of South China
2021-2022
ZheJiang Academy of Agricultural Sciences
2022
First Affiliated Hospital of University of South China
2022
UCHL1 positively regulates cardiac hypertrophy via stabilizing EGFR and highlighting it as a yet unknown therapeutic target.
The hedgehog (Hh) signaling pathway is essential for embryonic development and carcinogenesis. Activation of Hh has been identified in several types gastrointestinal cancers, including esophageal, gastric, pancreatic, liver cancers. Several recent studies suggest that activation can inhibit Wnt signaling. However, the molecular basis underlying this inhibition remains unclear. As transcription factors pathway, Gli molecules transform cells culture, their expression are associated with cancer...
Abstract CircRNAs (circular RNA) are reported to regulate onset and progress multiple cancers. Nonetheless, the function along with underlying mechanisms of circRNAs in HER‐2‐positive breast cancer (BC) remains unclear. CircRNA microarrays were performed elucidate expression profiles BC cells. circRNA levels quantified using qRT‐PCR assay. Various vitro vivo assays employed further explore effects circGFRA1 interactions circGFRA1, miR‐1228 AIFM2 Her‐2‐positive BC. CircGFRA1 was remarkably...
Metastasis suppressors are key regulators of tumor growth, invasion, and metastases. Loss metastasis has been associated with aggressive behaviors metastatic progression. We previously showed that regulator calcineurin 1, isoform 4 (RCAN1-4) was upregulated by the KiSS1 suppression pathway could inhibit cell motility when overexpressed in cancer cells. To test effects endogenous RCAN1-4 loss on thyroid vivo, we developed knockdown stable Subcutaneous xenograft models demonstrated promotes...
Na + /I − symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged a promising therapeutic target in diseases; yet, role miRs NIS-mediated RAIU been investigated. In silico analysis was used to identify that may bind 3′UTR human (h ). The top candidate miR-339-5p directly bound h ....
One of the mechanisms in hyperuricemia (HUA)-induced renal tubular injury is impairment Na+-K+-ATPase (NKA) signaling, which further triggers inflammation, autophagy, and mitochondrial dysfunction leads to cell injury. Here, we used RNA sequencing screen most likely regulators NKA signaling found that liver kinase B1(LKB1)/adenosine monophosphate (AMP)-activated protein (AMPK)/ mammalian target rapamycin (mTOR) pathway was abundantly enriched HUA. AMPK a key regulator energy metabolism;...
Abstract Background LAMA2 -related muscular dystrophy including congenital ( -CMD) and autosomal recessive limb-girdle dystrophy-23 (LGMDR23) is caused by pathogenic variants. We aimed to describe the natural history establish genotype–phenotype correlations in a large cohort of Chinese patients with dystrophy. Methods Clinical genetic data enrolled from ten research centers between January 2003 March 2021 were collected analyzed. Results One hundred thirty (116 -CMD 14 LGMDR23) included....
RAD23 (RADIATION SENSITIVE23) proteins are a group of UBL-UBA (ubiquitin-like-ubiquitin-associated) that shuttle ubiquitylated to the 26S proteasome for breakdown. Drought stress is major environmental constraint limits plant growth and production, but whether involved in this process unclear. Here, we demonstrated protein, MdRAD23D1, mediated drought response apple plants (Malus domestica). MdRAD23D1 levels increased under stress, its suppression resulted decreased tolerance plants. Through...
c-Myc is an important transcription factor that regulates cellular proliferation, cell growth, and differentiation. A number of transcriptional co-factors for have been described binding sites within highly conserved regions the transactivational domain (TAD). Given importance TAD, we set out to identify new proteins interact with this region using a yeast two-hybrid assay. HBP1 was identified in our screen as protein interacts full-length but not mutant lacking TAD. repressor has shown...
Chronic stress is one of the major causes that lead to depressive disorder, which a prevalent mood disorder worldwide. Many patients with do not benefit from available medication due complex etiology condition. Recently, long non-coding RNAs, molecular switches downstream genes expression, have been reported be involved in pathogenesis disorder. The RNA TCONS_00019174 has implicated risk and antidepressant effects, However, effect on responses investigated. This study designed determine...
// Tiantian Cui 1 , Amit Kumar Srivastava Chunhua Han Linlin Yang 2 Ran Zhao Ning Zou Meihua Qu Wenrui Duan 3 Xiaoli Zhang 4 and Qi-En Wang Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Radiation Oncology, Internal Medicine, Center for Biostatistics, Correspondence to: Wang, email: Keywords : XPC, E-Cadherin, non-small-cell lung cancer, Snail, ERK pathway Received December 28, 2014 Accepted February 13, 2015 Published March 12, Abstract Xeroderma...
The plateau environment impacts male reproductive function, causing decreased sperm quality and testosterone levels. L-carnitine can improve the semen microenvironment. However, role of in a high-altitude remains unclear. In our study, we investigated effects administration Wistar rat system injury model context simulated environment. Rats were randomly divided into normal control group (group A1, A2-low dose A3-high dose) groups B, C-low D-high with 20 rats each group. With exception...
Chronic stress is one of the major causes that lead to depressive disorder (MDD), which a prevalent mood worldwide. Lots MDD patients could not benefit from available medication due complex etiology MDD. Recently, long non-coding RNAs (lncRNAs), molecular switches downstream genes expression, have been reported be involved in pathogenesis LncRNA TCONS_00019174 has implicated risk and antidepressant effects, However, effect lncRNA on responses investigated. This study designed determine...
Abstract Beta‐transducin‐repeat‐containing protein (β‐TRCP) serves as a substrate‐recognition subunit of Skp1/Cullin/F‐box (SCF) β‐TRCP E3 ligases, involved in regulation several important signaling molecules. SCF ligases play critical role cell mitosis well various pathways. Here, we provide evidence to support that negatively regulates growth and motility lung cancer cells. With specific antibodies, detect loss β‐TRCP1 lines. One line contains an inactivated mutation the gene. Loss is also...
In vitro experiments have revealed that toll-like receptor 4 (TLR4) pathway is involved in the progression of immunoglobulin A nephropathy (IgAN) by induction proinflammatory cytokines. Evidence showed that, other disease models, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists been shown to exert anti-inflammatory effects through suppression expression and activity TLR4. However, interaction between PPAR-γ TLR4 IgAN has not fully studied both vivo. this study, we explored...
CCN1 plays distinct roles in various tumor types, but little is known regarding the role of leukemia.We analyzed protein expression leukemia cell lines and AML bone marrow samples. We also evaluated effects antibody- or siRNA-mediated inhibition on growth two (U937 Kasumi-1 cells) MEK/ERK pathway, β-catenin other related genes.U937 cells had markedly higher than 5 lines, was samples normal Blocking with an antibody U937 suppressed proliferation, increased apoptosis, down-regulated Bcl-xL...
Identifying key mediators of cancer invasion and metastasis is crucial to the development new more effective therapies. We previously identified Sohlh2 as an important inhibitor ovarian cell proliferation. However, function in migration remains unknown. In this paper, we report a novel MMP9 signaling pathway invasive cancer. Using immunohistochemistry staining, revealed expression was inversely correlated with human cancers. vitro experiments, forced led significant reduction invasion....
The study implies that bound polyphenol from millet bran dramatically prevents ganglioside GM3 catabolism followed by the suppression of P-gp, which eventually reverse drug-resistance in colorectal cancer cells to oxaliplatin.