A5008132111- Sex work and related issues
- HIV, Drug Use, Sexual Risk
- Sexuality, Behavior, and Technology
- Crime Patterns and Interventions
- Criminal Justice and Corrections Analysis
- Policing Practices and Perceptions
- Wildlife Conservation and Criminology Analyses
- Law, Economics, and Judicial Systems
- Jury Decision Making Processes
- Pancreatic and Hepatic Oncology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Protein purification and stability
- Ubiquitin and proteasome pathways
- Sexual Assault and Victimization Studies
- Intimate Partner and Family Violence
- Homelessness and Social Issues
- Peptidase Inhibition and Analysis
- Gun Ownership and Violence Research
- Asian Geopolitics and Ethnography
- Migration, Health and Trauma
- African Sexualities and LGBTQ+ Issues
- Judicial and Constitutional Studies
- Biochemical and Molecular Research
Northeastern University
2016-2025
Emory University
2025
The University of Texas at Austin
2024
Universidad del Noreste
2004-2024
Oregon Health & Science University
2009-2024
National Institute for Bioprocessing Research and Training
2014-2021
Merlin Park University Hospital
2021
University Hospital Galway
2021
Leeds Beckett University
2021
University of Memphis
2015-2016
Significance Increased kinase activity and suppressed phosphatase are hallmarks of oncogenic signaling. The transcription factor c-MYC, a master driver human cancer, is stabilized activated by persistent serine 62 phosphorylation. tumor suppressor protein 2A (PP2A) targets this site negatively regulates c-MYC. Here, we show that two cellular inhibitors PP2A, the SET oncoprotein cancerous inhibitor PP2A (CIP2A), overexpressed in breast depletion or inhibition CIP2A reduces c-MYC expression...
Research Summary The passage of new laws that criminalize the trafficking persons for labor and sexual services has raised public awareness about problem human trafficking. In response, police must understand problem, identify victims, make arrests. numbers victims identified to date, however, paled in comparison with official estimates, which leads some question existence a problem. Missing from this debate is information how frequently encounter well prepared officers are handle these...
Since 2000, the federal government and all fifty states have passed laws that criminalize trafficking of persons for labor commercial sex. To date, relatively few human cases been identified, investigated, prosecuted by local criminal justice authorities. Using data from case records qualitative interviews with police, prosecutors, victim service providers in twelve counties, we discuss challenges police face identifying trafficking. We find culture agencies perceptions officials about do...
The Myc oncoprotein is considered a master regulator of gene transcription by virtue its ability to modulate the expression large percentage all genes. However, mechanisms that direct Myc's recruitment DNA and target selection elicit specific cellular functions have not been well elucidated. Here, we report Pin1 prolyl isomerase enhances serine 62-phosphorylated coactivators select promoters during activation, followed promoting release associated with degradation. This facilitates...
Charge variant analysis (CVA) of monoclonal antibodies (mAbs) using cation exchange chromatography is routinely used as a fingerprint the distribution posttranslational modifications present on molecule. Traditional salt or pH based eluents are not suited for direct coupling to mass spectrometry due nonvolatility high ionic strength. This makes further complicated when an alteration in charge profile emergence additional peak encountered. Here, use gradient elution volatile, low strength...
Intratumoral phenotypic heterogeneity has been described in many tumor types, where it can contribute to drug resistance and disease recurrence. We analyzed ductal neuroendocrine markers pancreatic adenocarcinoma, revealing heterogeneous expression of the marker Synaptophysin within lesions. Higher percentages Cytokeratin-Synaptophysin dual positive cells correlate with shortened disease-free survival. observe similar lineage mouse models tracing indicates that arise from exocrine...
Pancreatic cancer is a deadly disease that usually diagnosed in the advanced stages when few effective therapies are available. Given aggressive clinical course of this and lack good treatment options, development new therapeutic agents for pancreatic upmost importance. Several pathways have shown to contribute progression negatively regulated by tumor suppressor protein phosphatase 2A (PP2A). Here, endogenous inhibitors PP2A, SET (also known as I2PP2A) cancerous inhibitor PP2A (CIP2A), were...
Research Summary The police have a duty to provide assistance crime victims. Despite the importance of this role, scholars examining effectiveness historically been less attentive needs As are increasingly called on combat sex and labor trafficking crimes, it is timely explore how new population victims served by police. Information from review human investigations in‐depth interviews with service providers in three U.S. communities indicates that often do not trust rarely seek their...
Social control theory asserts that strong social bonds inhibit delinquency, whereas weak offer little resistance to offending. In the development of this theoretical perspective, new research suggests type and magnitude have differing effects on male female delinquency. This study adds our understanding how factors parental attachment, involvement in diverse prosocial activities, belief traditional norms, school climate affect both young men's women's reports serious delinquency risky...
Although the US federal government and all 50 states have passed legislation that defines human trafficking as a crime specifies stiff penalties for such offenses, little is known about how police perceptions of influence investigation response strategies. Previous research confirms definitions are ambiguous commonly lack training experience necessary to identify crime. Using schema theory guide our inquiry, we explore existing responses trafficking. In addition, examine new laws change...
Host cell proteins (HCPs) are bioprocess-related impurities arising from cell-death or secretion nonhuman cells used for recombinant protein production. Clearance of HCPs through downstream purification (DSP) is required to produce safe and efficacious therapeutic proteins. While traditionally measured using anti-HCP ELISA, more in-depth approaches HCP characterization may ensure that risks patients adequately assessed. Mass spectrometry methods provide rationale targeted removal strategies...
Hate crimes, often referred to as bias-motivated have garnered greater public attention and concern political rhetoric in the United States internationally has promoted exclusion of people based on their group identity. This review examines what we know about trends hate crime behavior legal responses this problem across four main domains. First, describe framework recent attempts expand protections beyond historically disenfranchised groups. Second, examine patterns victimization. Third, is...
This guide is a blueprint that police and communities can use to develop data collection systems. It offers practical information about implementing these systems analyzing the data. The not intended serve as comprehensive thorough inventory of all existing focuses on providing detailed descriptions efforts in few selected sites: San Jose, California, which has designed simple letter-code system allowing be collected verbally (via radio) or by computer; Diego, utilizes an online system;...
High expression of the oncoprotein Myc has been linked to poor outcome in human tumors. Although MYC gene amplification and translocations have observed, this can explain overexpression only a subset is part controlled by its protein stability, which be regulated phosphorylation at threonine 58 (T58) serine 62 (S62). We now report that stability increased number breast cancer cell lines correlates with S62 decreased T58. Moreover, we find same shift primary cancers. The signaling cascade...
In response to domestic and international concern about individuals being exploited for labor or commercial sex, the U.S. Government passed legislation in 2000, creating a new crime of human trafficking devoting resources identification victims prosecution perpetrators. Since that time, all 50 states have criminalizing persons, yet law enforcement responses these legal mandates been uneven. Recent research suggests police agencies are generally unprepared identify respond incidents local...