A5053967662- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Hernia repair and management
- Genetic factors in colorectal cancer
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Cells and Metastasis
- Pelvic and Acetabular Injuries
- Image and Signal Denoising Methods
- Cell Adhesion Molecules Research
- Advanced Data Compression Techniques
- Stoma care and complications
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Amoebic Infections and Treatments
- Nutrition and Health in Aging
- Advanced Image Processing Techniques
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Esophageal Cancer Research and Treatment
Sichuan University
2016-2025
Communication University of China
2024
West China Hospital of Sichuan University
2012-2023
State Key Laboratory of Biotherapy
2013-2021
Weatherford College
2020
Huangshi Central Hospital
2015
Hubei Polytechnic University
2015
// Mingtian Wei 1, 2, * , Tinghan Yang Xiangzheng Chen 3 Yangping Wu 2 Xiangbing Deng 1 Wanbin He Jinliang and Ziqiang Wang Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, 610041, State Key Laboratory Biotherapy Cancer Center/Collaborative Innovation Center for Biotherapy, Medical School, Liver Surgery Transplantation Center, These authors have contributed equally to this work Correspondence to: Wang, email: wzqtrial@gmail.com Keywords: exosomes,...
Background Cachexia has a devastating impact on survival and quality of life for many cancer patients contributes to nearly one-third all deaths; also, it is associated with poor responses chemotherapy survival. A better understanding the underlying mechanisms cancer-associated cachexia (CAC), coupled effective therapeutic approaches, will improve management progressive functional impairment in patients. Salidroside, phenylpropanoid glycoside Rhodiola rosea L, been reported possess potential...
Clinical guidelines recommend ≥12 examined lymph nodes (ELNs) for colon cancer staging, but more may be necessary accuracy. This study utilized nodal staging scores (NSS) to identity the optimal number of ELNs based on tumor location and T stage, assess its prognostic impact. Data from 80,792 patients in Surveillance, Epidemiology, End Results (SEER) database (2004-2014) 2,300 West China Hospital (WCH) cohort (2008-2014) with stage I-III resected were analyzed. Optimal was estimated using a...
Abstract Intratumor bacteria, a critical component of the tumor microenvironment, can facilitate growth and contribute to development resistance chemotherapeutic agents. The agents not only induce protective autophagy in tumors, contributing drug resistance, but also exert minimal effects on bacteria within tumor, thereby potentially accelerating recurrence. To address this tough issue, vermiculite/copper telluride bio‐heterojunctions (VIC bio‐HJs) have been developed enhance eradicate...
The aim of this study was to discover immune-nutritional indicators that can preoperatively predict short-term mortality in older patients undergoing emergency gastrointestinal surgery. We retrospectively analyzed than 65 years age who underwent various types surgery under general anesthesia between January 2012 and December 2023. were defined according previous literature. primary endpoint 90-day survival after A total 4120 included study. ROC curves the decision curve analysis for eight...
Annexin A2 (ANXA2) is known to be a tumourigenic molecule and highly expressed in colorectal cancer (CRC). Its diagnostic prognostic value not fully understood. This study was designed investigate the relationship between ANXA2 expression, clinicopathological characteristics, tumour recurrence survival.Immunohistochemical staining used evaluate expression 150 matched samples from patients with CRC. Overall survival were determined by Kaplan-Meier analysis. The Cox proportional hazards model...
DDR1 has been identified as a cancer‐associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues. Clinically approved multi‐kinase inhibitors, such nilotinib, inhibit DDR1‐mediated tumor growth xenograft models, suggesting might be potential target for cancer treatments. Here, we employed an antibody‐based strategy with novel anti‐DDR1 antibody‐drug conjugate (ADC) colon carcinoma treatment. We developed T 4 H 11 ‐DM4, ADC targeting which...
Abstract Introduction Anastomotic leakage (AL) remains the most dreaded and unpredictable major complication after low anterior resection for mid‐low rectal cancer. The aim of this study is to identify patients with high risk AL based on machine learning method. Methods Patients cancer undergoing were enrolled from West China Hospital between January 2008 October 2019 split by time into training cohort validation cohort. least absolute shrinkage selection operator (LASSO) method stepwise...
Recent advances in generative compression methods have demonstrated remarkable progress enhancing the perceptual quality of compressed data, especially scenarios with low bitrates. However, their efficacy and applicability to achieve extreme ratios (< 0.05 bpp) remain constrained. In this work, we propose a simple yet effective coding framework by introducing vector quantization (VQ)–based models into image domain. The main insight is that codebook learned VQGAN model yields strong...
The reduction of oil fouling in pipes and tanks is essential for the storage transportation industry. In this study, a superhydrophilic/underwater superoleophobic surface (SUSS) with high wearability, weatherability, durability was developed using facile two-step synthesis method used to expel fouled from water without surfactant. Some typical oils, including kerosene white oil, can be spontaneously expelled by static water; however, rapeseed requires motive expulsion because its affinity...
To evaluate the impact of visceral obesity on laparoscopic total mesorectal excision (TME) and decide best index to reflect completion mesorectum perioperative outcomes. Patients with rectal cancer who underwent TME were enrolled. The data including body mass (BMI), fat area (VFA), area/body surface (VFA/BSA), ratio (MFR), pelvic (PFA), (PFR), mesorectum, other outcomes collected. Data analyzed. A 322 patients enrolled between 2011 2014. There was no significantly difference BMI groups (P ≥...
Abstract Background Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset who are predisposed to high risk recurrence or death. Previous evidence was limited by small sample sizes and lack validation. Methods We aimed identify early indicators develop a stratification model inform prognosis employing two large prospective cohorts. Prognostic factors for II tumors, including T stage,...
Discovered On Gastrointestinal stromal tumors protein 1 (DOG1), a major calcium-activated chloride channel, has been used as common diagnostic marker for gastrointestinal tumors. However, the therapeutic application of DOG1 was not well defined. Here, we aim to investigate its potential target an antibody-drug conjugate (ADC) in various cancers alimentary tract and metastasis. The expression profile determined among TCGA samples tissue microarrays. High levels were ubiquitously observed...