A5101558375- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Hepatitis C virus research
- Biological Activity of Diterpenoids and Biflavonoids
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Crystal structures of chemical compounds
- Synthesis of Organic Compounds
- Tuberculosis Research and Epidemiology
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Cancer Treatment and Pharmacology
- Bioactive Natural Diterpenoids Research
- Cancer therapeutics and mechanisms
- Phytochemistry and biological activity of medicinal plants
- Phytochemical compounds biological activities
- Morinda citrifolia extract uses
- Viral Infections and Outbreaks Research
- Tryptophan and brain disorders
- Fungal Biology and Applications
- Sesquiterpenes and Asteraceae Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2023
Chinese Academy of Medical Sciences Dermatology Hospital
2023
Nanjing Medical University
2023
Nanjing Drum Tower Hospital
2023
Chinese Academy of Sciences
1999-2021
Beijing Forestry University
2021
State Forestry and Grassland Administration
2021
Institute of Geographic Sciences and Natural Resources Research
2021
Academy of Medical Sciences
2020
Peking Union Medical College Hospital
2020
Pre-schisanartanin (1) and schindilactones A−C (2−4) were isolated from Schisandra chinensis. Among them, compound 1 had an unprecedented carbon skeleton. More importantly, the structure features of this provided new insight into biosynthesis triterpenoids with schisanartane Their structures determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, on basis absolute one related nortriterpenoid (5), which was for first time a modified Mosher method.
Six novel dibenzyl bromophenols (1−6) with different dimerization patterns and two propyl bromophenol derivatives (7 8), together 11 known derivatives, were isolated from the ethanolic extract of brown alga Leathesia nana. On basis spectroscopic methods structures new compounds determined as 5,6'-diethyloxymethyl-3,4,2'-tribromo-2,3',4'-trihydroxydiphenyl ether (1), 2-(2,3-dibromo-4,5-dihydroxybenzyl)-3,5-dihydroxy-4-methoxybenzyl alcohol (2),...
Two novel spirooliganones A (1) and (2), a pair of spiro carbon epimers, with rare dioxaspiro skeleton were isolated from the roots Illicium oligandrum. The structures fully determined by spectroscopic analysis chemical methods, especially modified Mosher's method, X-ray diffraction analysis. Spirooliganone B was found to exhibit more potent activities against coxsackie virus B3 influenza (H3N2) (IC50 3.70–5.05 μM) than spirooliganone A. biosynthetic pathway involving hetero-Diels–Alder...
Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures 1 including their absolute configurations, determined by spectroscopic methods, single-crystal X-ray diffraction analysis, chemical methods. Compound showed weak cytotoxicity moderate immunosuppressive activity.
Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure established by comprehensive NMR MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 μg/mL) showed anti-HIV activity EC50 = 20.69 ± 3.31 μg/mL a selectivity index 6.62.
Psoriasis is a common chronic inflammatory disease, but most of its current treatments come with high risk side effects. As one the world’s top three beverages, tea has traditional history being used as treatment for skin conditions due to safety profile, anti-inflammatory and other properties. In this study, we investigated anti-psoriasis effects ethanol extracts black tea, green white from southeastern China. The compositions (TEs) were first determined by UPLC-Q-Exactive-Orbitrap MS then...
Four new styryllactones.leiocarpin A (I), 7-epi-goniodiol (2), leiocarpin B (3) and C (4), respectively, were isolated from the stem bark of Goniothalamus leiocarpus.Their structures elucidated by means spectral method.The relative configurations 1. 2 3 determined X-Ray crystallographic analysis.Compounds possess antitumor activities.Goniothalamus leiocarpus ( ~o n a c e family) is tropical plant distributed in south Yunuan province China.We have four known annonaceous acetogenins' seeds...
Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures 1-5 determined by spectroscopic analysis, as well X-ray crystallographic analysis 1. Compounds 1-11 evaluated against K562 leukemia cells for their cytotoxic effects.
Chronic hepatitis induced by B virus (HBV) infection is a serious public health problem, leading to hepatic cirrhosis and liver cancer. Although the currently approved medications can reliably decrease load prevent development of diseases, they fail induce durable off-drug control HBV replication in majority patients. The roots Isatis indigotica Fortune ex Lindl., traditional Chinese medicine, were frequently used for prevention viral disease China. In present study, (−)-lariciresinol...
IMB1603, a spiro-benzothiazone compound discovered by our lab, displayed potent anti-MTB activity in vitro and vivo. In this study, we reported series of new BTZs containing the hexahydropyrrolo[3,4-c]pyrrol moiety based on structure IMB1603. Among them, 11 24 (MIC < 0.035 μM) MDR-MTB (MIC, 0.053-0.102 activity, good solubility (1.82-1.85 μg mL-1), low cytotoxicity (CC50 > 200 μM), suggesting may serve as promising candidates for further study. The molecular docking study toward DprE was...
As a part of our systematic investigation chemical constituents Polyporaceous family fungi (Basidiomycetes), we studied the fungus Fomes cajanderi P. Karst collected from Jiling province, China in 1997, and isolated 15 compounds, which, compound 5 is naturally occurring new metabolite, while 9, 11 12 are derivatives. Their structures were identified by means MS, NMR spectra X-ray crystallographic analysis.
In the title compound, C20H32N5O8P·2H2O, molecules are linked to each other via intermolecular N—H⋯O, N—H⋯N, O—H⋯O and O—H⋯N hydrogen bonds with water acting as both acceptors donors.
A novel chlorine-containing neo-clerodane diterpene, teupernin D, and two known compounds, teucvidin teuflin, were isolated from the whole parts of Teucrium pernyi. The structure D was characterized as (12S)-15, 16-epoxy-8β-hydroxy-17-chloro-19-nor-10α-neo-cleroda-4, 13, 14-triene-18, 6β : 20, 12-diolide on basis spectral evidence. absolute configuration established by circular dichroism (CD) spectrum confirmed X-ray crystallographic analysis.
魏春雪 1,2 杨 璐 2,3 汪金松 2* 杨家明 史嘉炜 田大栓 2 周青平 1* 牛书丽 1 西南民族大学青藏高原研究院, 成都 610041; 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室, 北京 100101; 3 北京林业大 学国家林业和草原局森林经营工程技术研究中心, 100083 摘 要 根系是植物吸收土壤水分和养分的重要器官, 驱动着多个生态系统过程, 该研究揭示了实验增温对根系生物量的影 响及机制, 可为气候变暖背景下土壤碳动态和生态系统过程的变化提供理论依据。该研究从已发表的151篇国内外研究论文 中收集到611组数据, 通过整合分析(meta-analysis)方法研究了实验增温对根系生物量(根系总生物量、粗根生物量、细根生物 量、根冠比)的影响, 并探讨了增温幅度、增温年限、增温方式的影响, 以及根系生物量对增温的响应与本底环境条件(生态 系统类型、年平均气温、年降水量、干旱指数)的关系。结果表明: (1)模拟增温使细根生物量显著增加8.87%,而对根系总生 物量、粗根生物量、根冠比没有显著影响; (2)中等强度增温(1-2...