A5100776913- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Radiotherapy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease and Transplantation
- Effects of Radiation Exposure
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- RNA modifications and cancer
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- interferon and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Response and Inflammation
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
Fudan University
2015-2025
Ningxia Medical University
2025
Sun Yat-sen University
2015-2024
Zhongshan Hospital
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Anhui Medical University
2020-2024
First Affiliated Hospital of Anhui Medical University
2020-2024
Sun Yat-sen University Cancer Center
2023
West China Second University Hospital of Sichuan University
2023
Sichuan University
2017-2023
Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes remain to be systemically identified for lung cancer. Through genome-wide screening tumor-suppressive transcription factors, we demonstrate here that GATA4 functions as an essential tumor in vitro and vivo. Ectopic expression results cell senescence. Mechanistically, upregulates multiple miRNAs targeting TGFB2 mRNA causes ensuing WNT7B downregulation eventually triggers Decreased level clinical...
Stereotactic body radiotherapy (SBRT) and programmed cell death 1 inhibitors have shown potential in treating hepatocellular carcinoma (HCC) retrospective studies.To evaluate the efficacy of combining SBRT with sintilimab for patients recurrent or oligometastatic HCC.This trial involved HCC intravenously treated plus every 3 wk 12 mo until disease progression. The primary endpoint was progression-free survival (PFS).Twenty-five were enrolled from August 14, 2019, to 23, 2021. median...
Nasopharyngeal carcinoma is not a disease to be treated primarily by surgery. Radiation the first choice of treatment. But, once it recurs, second course radiation controls only small portion patients, with high risk accumulated injury. We discuss outcome salvage surgery in nine cases nasopharyngeal recurrence and 69 neck metastasis that was uncontrolled or had recurred after irradiation evaluated. A five-year survival rate 44% for primary lesions 49% node metastases justifies rationale on...
Stereotactic body radiation therapy (SBRT) is an advanced technique of external beam that delivers large ablative doses radiation. In the past decade, many cancer centers have adopted SBRT as one mode radically treating small-sized hepatocellular carcinoma (HCC), based on encouraging clinical outcomes. thus seems reasonable first-line treatment inoperable HCC confined to liver. However, most studies date been retrospective in nature, with key issues still under investigation.The...
The mechanism of pancreatic cancer metastasis remains poorly understood. Recently, lncRNA CASC2 has been demonstrated to be a tumor suppressor in various types cancer. This study aimed explore the regulation metastasis.The expression levels and miR-21 cells were detected by qRT-PCR. Using specific vectors, including mimics or shRNA, CASC2, PTEN altered. association between was detected. Then, cell migration invasion assessed using transwell assay.CASC2 downregulated lines CAPAN-1, BxPC-3,...
Background and objective: Radiation-induced lymphopenia has a tangible impact on overall survival (OS) in multiple solid tumors. We investigated the association between circulating lymphocyte populations (CLPs) before after stereotactic body radiation therapy (SBRT) OS patients with hepatocellular carcinoma (HCC). Materials Methods: Seventy-eight HCC treated SBRT January 2013 June 2017 were retrospectively analyzed. Baseline post-treatment total peripheral counts (TPLCs) values of different...
The optimal treatment for adrenal metastases from hepatocellular carcinoma (HCC) has not been established. This study analyzed the effects of radiation therapy (RT) such and identified clinical features predictors survival in these patients. We retrospectively investigated 55 patients with metastasis HCC who had treated RT. Radiation doses to lesions ranged 26 60 Gy, while intrahepatic were by surgical resection, transarterial chemoembolization (TACE), liver transplantation, and/or RT was...
The purpose of this study was to use 4-dimensional-computed tomography (4D-CT) evaluate respiration-induced liver motion magnitude and influencing factors in patients with intrahepatic tumors undergoing abdominal compression. From January 2012 April 2016, 99 were included study. They all underwent 4D-CT assess respiratory motion. This performed during compression 53 free-breathing (no compression) 46 patients. We defined as being effective managing the breath amplitude if cranial-caudal (CC)...
Purpose: While abdominal compression (AC) can be used to reduce respiratory liver motion in patients receiving helical tomotherapy for hepatocellular carcinoma, the nature and extent of this effect is not well described. The purpose study was evaluate changes magnitude three‐dimensional with using four‐dimensional (4D) computed tomography (CT) images several plate positions. Methods: From January 2012 October 2015, 72 intrahepatic carcinoma divided into four groups underwent 4D‐CT scans...
Purpose . To investigate whether lymphocyte nadir induced by radiation is associated with survival and explore its underlying risk factors in patients hepatocellular carcinoma (HCC). Methods Total counts were collected from 184 HCC treated radiotherapy (RT) complete follow-up. Associations between gross tumor volumes (GTVs) radiation-associated parameters evaluated Pearson/Spearman correlation analysis multiple linear regression. Kaplan–Meier analysis, log-rank test, as well univariate...
The standard treatment for stage III non-small-cell lung cancer (NSCLC) is still 60 Gy in conventional fractions combined with concurrent chemotherapy; however, the resulting local controls are disappointing. aim of this study was to compare and assess feasibility efficacy hypofractionated chemoradiotherapy using helical tomotherapy (HT) fractionation as opposed three-dimensional conformal radiotherapy (3D-CRT) NSCLC.Sixty-nine patients (AJCC 7th edition) NSCLC who underwent definitive...
Lung cancer is a common malignant tumor with high morbidity and mortality. Here we compared the effects outcome between central peripheral stage I lung using image-guided stereotactic body radiotherapy. From June 2011 to July 2013, total of 33 patients were enrolled. A 50 Gy in 10 fractions or 60 was delivered arm (n = 18), while 5 15). Statistical analyses performed logistic regression analysis Kaplan-Meier method. The mean follow-up time 38.1 months. Three-month, 1-, 2-, 3-year overall...
Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC who have received radiotherapy but not undergone surgery been systematically studied. Thus, were investigated in this study based on Surveillance, Epidemiology, and End Results (SEER) Medicare database. Methods: A screening process was used select cases from SEER Survival analyzed using Kaplan-Meier method log-rank test, Cox...
Purpose: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) are inflammatory indexes that may reflect immune response to tumors prognosis. We investigated the prognostic values of pre-treatment post-treatment NLR PLR changes in those ratios patients with small hepatocellular carcinoma (sHCC) treated stereotactic body radiation therapy (SBRT). Patients methods: Sixty who received SBRT were retrospectively reviewed. calculated by division neutrophil platelet counts,...
Liver tissue interstitial fluid (TIF) a special microenvironment around liver cells, which may play vital role in cell communication during injury. Moreover, toll-like receptor 4 (TLR4) is an important trigger of the immune response that also injuries, including radiation-induced disease (RILD). Therefore, purpose this study was to identify roles TLR4-dependent and TIFs RILD after radiation therapy (RT) for cancer. This consisted two phases, primary phase, livers TLR4 mutant (TLR4–) normal...