A5026501110- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Circular RNAs in diseases
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Renal Transplantation Outcomes and Treatments
- Occupational and environmental lung diseases
- Periodontal Regeneration and Treatments
- Radiation Therapy and Dosimetry
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Bone and Joint Diseases
- Gyrotron and Vacuum Electronics Research
Shanghai Medical College of Fudan University
2020-2024
Fudan University Shanghai Cancer Center
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Zhongshan Hospital
2016-2022
Fudan University
2016-2022
Sun Yat-sen University
2016-2022
Zhejiang Hospital
2022
Zhejiang University
2017-2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2020
Hangzhou Center for Disease Control and Prevention
2020
To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) its associations with patient outcomes in non-small cell lung cancer (NSCLC).Subjects consisted 115 patients who had received chemoradiation therapy (CRT) different doses fractions for unresectable stage III NSCLC. Clinical laboratory records were reviewed to assess changes total lymphocyte counts (TLCs) RT. The TLCs clinical features, analyzed.The...
// Shiming Shi 1,* , Qing Chen 2,3,* Luxi Ye 1 Dan Yin 2,4 Xuedong Li 2 Zhi Dai and Jian He Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, P.R. China Liver Cancer Institute, 3 General Surgery, Hospital South, Shanghai Public Health Clinical Center, 4 Institute Biomedical Sciences, * These authors have contributed equally to this work Correspondence to: He, email: Dai, Keywords : hepatocellular carcinoma; blood lymphocyte-to-monocyte ratio;...
Non-local progression is a major concern in non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT). Herein we aimed to create pre-treatment prognostic nomogram for patients Stage I NSCLC receiving SBRT.We retrospectively studied 182 eligible patients. Patients were randomly divided into model (70%) group and validation (30%) group. In the group, thirteen parameters consisting of patient, treatment, tumor factors multivariate Cox proportional hazards regression...
Recent studies indicate that EGFR-mutant non-small cell lung cancer (NSCLC) is a heterogeneous disease with varying prognosis. In order to design an optimized surveillance strategy and identify potential candidates for adjuvant therapy, the patterns risks of postoperative recurrence in completely resected NSCLC should be investigated, which are currently largely unknown.Consecutive patients curatively EGFR-positive receiving standard chemotherapy without EGFR tyrosine kinase inhibitors...
Radiation pneumonitis is the most frequent acute pulmonary toxicity following stereotactic body radiation therapy for lung cancer. Here, we investigate clinical and dosimetric factors associated with symptomatic in patients stage I non–small cell cancer treated therapy. A total of 67 who received at our institution were enrolled, their clinicopathological parameters recorded analyzed. The median follow-up period was 26.4 months (range: 7-48 months). In univariate analysis, tumor size ( P =...
The standard treatment for stage III non-small-cell lung cancer (NSCLC) is still 60 Gy in conventional fractions combined with concurrent chemotherapy; however, the resulting local controls are disappointing. aim of this study was to compare and assess feasibility efficacy hypofractionated chemoradiotherapy using helical tomotherapy (HT) fractionation as opposed three-dimensional conformal radiotherapy (3D-CRT) NSCLC.Sixty-nine patients (AJCC 7th edition) NSCLC who underwent definitive...
Radiation-induced lung injury (RILI) is a main threat to patients who received thoracic radiotherapy. Thus, understanding the molecular mechanism of RILI great importance. Circular RNAs (circRNAs) have been found act as regulator multiple biological processes, and circRNA-microRNA (miRNA)-mRNA axis could play an important role in signaling pathway many human diseases including radiation injury.First, circRNA miRNA mouse model were investigated. The mice 12 Gy irradiation, irradiated tissues...
In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Baseline tissue blood from 15 showed a strong positive correlation (Pearson = 0.937), nearly all mutations were markedly reduced later course of treatment, indicating treatment-related response. This study suggests that LA-NSCLC, b-TMB is reliable biomarker, monitoring can help distinguish might...
Pulmonary large cell neuroendocrine cancer (LCNEC) is commonly classified as non-small lung (NSCLC). Even for stage I disease, after surgery the survival always poor, but clinical research on LCNEC scant and with unsatisfying sample sizes. Thus, we conduct first study using Surveillance, Epidemiology, End Results (SEER) database to compare between other types of NSCLC.From 2004 2016, 473 patients IA LCNEC, 17,669 adenocarcinoma (LADC) 8,475 squamous (LSCC), all treated were identified. In...
External beam radiotherapy (EBRT) has been reported to be effective in palliating painful bone metastases, but the optimal fractions and doses for treating metastases from hepatocelluar carcinoma (HCC) are not established. This study aimed compare toxicity efficacy conventional fraction versus hypofraction schedules. From January 2009 through December 2014, 183 patients with HCC were randomly assigned EBRT (Group A) or B). Study outcomes pain relief, response rate duration, overall survival,...
Background: Hereditary renal hypouricemia (HRH) is a genetically heterogenetic disease. Patients with HRH are almost asymptomatic; but some may experience exercise-induced acute kidney injury (EAKI) and nephrolithiasis which bring concerns regarding the risk-benefit ratio as marginal donors. This study examined pathogenic mutations of in two recipients after receiving transplantation, providing preliminary evidence for mechanism hypouricemia. Methods: Two participants underwent detailed...
Expression of transmembrane protein 106A (TMEM106A) has been reported to be dysregulated in several types cancers. However, the role TMEM106A hepatocellular carcinoma (HCC) is still unknown. In present study, we demonstrate that markedly downregulated HCC compared with normal liver tissue. particular, tumor-specific DNA methylation frequently observed tumor tissues from patients. Immunohistochemistry and pyrosequencing reveal a significant relationship between downregulation expression....
// Zaiyou Dai 1, 2, 3, 4, * , Luxi Ye Dajin Chen 3 Xing Zhang Meifang Wang Rending Jianyong Wu and Jianghua 1 Department of The Kidney Disease Center, First Affiliated Hospital, College Medicine, Zhejiang University, Zhejiang, China 2 Key Laboratory Prevention Control Technology, Third Grade under National State, Administration Traditional Chinese 4 Nephrology, People’s Hospital Wenling, These authors have contributed equally to this work Correspondence to: Wu, email:...
Lung cancer is the most common causes of death worldwide and patients with non-small-cell lung (NSCLC) have various prognosis. We conducted this study to identify prognostic predictors establish a index score (PIS) for Stage I NSCLC after stereotactic body radiation therapy (SBRT).A total 131 consecutive who underwent SBRT in our institute were analyzed retrospectively. The Cox proportional hazards regression model was applied predictors. Time-dependent receiver operating characteristic...
Following surgery for early stage non-small-cell lung cancer (NSCLC), de novo pulmonary tumors are common. This study aimed to assess the efficacy, patterns of failure, and toxicity stereotactic body radiotherapy (SBRT) in treatment following curative resection NSCLC.We reviewed medical data patients who had received definitive intent SBRT small at Zhongshan Hospital, Fudan University, between June 2011 December 2017. Patients experienced complete prior NSCLC before were identified further...
Abstract The purpose of this study was to evaluate the changes in magnitude three‐dimensional (3D) liver motion after resection/transplantation patients with hepatocellular carcinoma ( HCC ) using four‐dimensional (4D)‐computed tomography CT images. From January 2012 April 2016, 74 underwent 4D‐ scans under a free‐breathing state assess respiratory motion. Of patients, 40 did not have (Group A), 34 resection/transplantation. 15 major or minor resection right lobe B), 14 left C), and five...
Objective. To explore the role and mechanism of epithelial-mesenchymal transition (EMT) mediated by inflammatory stress-induced TGF-β1 in promoting arteriovenous fistula stenosis. Methods. The cells HK-2 were cultured adding TGF-β1. optimal stimulation time was determined after added. divided into two groups, DMEM/F12 medium added to one group (the control group), other treated with (10 ng/ml) serum-free stimulate cell differentiation mesenchymal. Results. stably expressed being transfected...
A large portion of patients with early-stage non-small-cell lung cancer (NSCLC) who are receiving stereotactic body radiation therapy (SBRT) medically inoperable due to compromised pulmonary function, and among these emphysema (PE) is common. However, the relationship between PE radiation-induced injuries remains unclear. In this study, we aimed describe full spectrum computed tomography (CT) features after SBRT for NSCLC, explore their variables, including dosimetric factors. all, 71 were...