A5038363135- Aortic aneurysm repair treatments
- Diagnosis and Treatment of Venous Diseases
- Lymphatic System and Diseases
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Body Contouring and Surgery
- Peripheral Artery Disease Management
- Mesenchymal stem cell research
- Abdominal vascular conditions and treatments
- Thermoregulation and physiological responses
- Wound Healing and Treatments
- Gastrointestinal disorders and treatments
- Systemic Sclerosis and Related Diseases
- IgG4-Related and Inflammatory Diseases
- Vascular Malformations and Hemangiomas
- Cardiac and Coronary Surgery Techniques
- Protein Kinase Regulation and GTPase Signaling
- Cardiac Ischemia and Reperfusion
- Diabetic Foot Ulcer Assessment and Management
- Neuroendocrine Tumor Research Advances
- Body Composition Measurement Techniques
- Cardiac Valve Diseases and Treatments
Yamaguchi University
2016-2025
Ministry of Health Labour and Welfare
2020
Kumamoto University
2019
Iwate Medical University
2019
Nara Medical University
2019
National Rehabilitation Center for Persons with Disabilities
2016
Yamaguchi Prefectural University
2016
Mochida Pharmaceutical (Japan)
2006
Naga Municipal Hospital
2004
Yamaguchi University Hospital
2002
Objective: This study aimed to evaluate the effect of inferior mesenteric artery (IMA) embolization during endovascular aneurysm repair (EVAR) in patients at high risk type II endoleak (T2EL) randomized controlled trial (RCT). Summary Background Data: Several studies have demonstrated a reduction T2EL by IMA before EVAR. However, there been no RCT confirming efficacy embolization. Methods: Patients scheduled for elective EVAR between April 2014 and March 2018 were eligible. (IMA patency with...
To clarify whether ultrasound findings of skin and subcutaneous tissue represent the severity lymphedema.Thirty-five patients with secondary lower extremity lymphedema caused by intrapelvic lymph node dissection during cancer surgery, who first visited our clinic between April 2009 March 2012, were studied retrospectively. At their visit, thickness, echogenicity assessed at 8 points on thigh leg both legs using an 11-MHz transducer. These correlated International Society Lymphology (ISL)...
To elucidate the differences in subcutaneous ultrasound findings between dependent edema (DE) and secondary lower extremity lymphedema (LE).Twenty legs 10 patients with DE 54 35 LE, who first visited our clinic April 2009 December 2012, were studied retrospectively. Subcutaneous echogenicity echo-free space (EFS) assessed at 8 points on thigh leg using an 8-12 MHz transducer.In DE, was increased most leg, without a difference medial lateral side. The EFS remarkable side more severe. In early...
Aims Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammation, which contributes to the pathological remodeling of extracellular matrix. Although mechanical stress has been suggested promote inflammation in AAA, molecular mechanism remains uncertain. Periostin is a matricellular protein known respond strain. The aim this study was elucidate role periostin mechanotransduction pathogenesis AAA. Methods and Results We found significant increases levels walls human AAA...
HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors (statins) have been suggested to attenuate abdominal aortic aneurysm (AAA) growth. However, the effects of statins in human AAA tissues are not fully elucidated. The aim this study was investigate direct on proinflammatory molecules walls ex vivo culture. Simvastatin strongly inhibited activation nuclear factor (NF)-κB induced by tumor necrosis (TNF)-α walls, but showed little effect c-jun N-terminal kinase (JNK)...
Background Saphenous vein grafts (SVGs) are broadly used in coronary artery bypass grafting despite their inferior patency compared with arterial grafts. Recently, the no-touch technique (NT), which an SVG is harvested a pedicle of perivascular adipose tissue (PVAT) without conduit distension, was shown to improve long-term conventional preparation (CV), wherein outer removed distension. The NT also reportedly associated reduced atherosclerosis. Although endothelial damage provoked by...
Abstract Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated associated mechanisms after performing remote IPC (rIPC) lower limbs by clamping abdominal aorta in mice. Subsequent experiments showed decreased damage and paralysis following spinal cord (SCI). Concomitantly, plasma vascular endothelial growth factor (VEGF) levels were increased 24 h rIPC compared with those sham-operated animals. subsequent...
IntroductionType II endoleak (T2EL) is the most common type of after endovascular aneurysm repair (EVAR) and a indication for reintervention due to late sac enlargement. Although pre-emptive embolization inferior mesenteric artery (IMA) has been proposed prevent this, no studies have prospectively demonstrated its efficacy. This study aimed prove validity IMA during EVAR in selective cases by analyzing mid-term outcomes randomized clinical trial (RCT).MethodsThis single-center,...
Objectives: This study aimed to investigate the actual detection process and diagnostic methods for asymptomatic abdominal aortic aneurysm (AAA) in a multicenter setting, plan an effective screening strategy AAA. Methods: The subjects of this were collected retrospective manner at 7 facilities. A total 1894 patients with AAA, including iliac artery aneurysms, who considered confirmed initial diagnosis from January 2018 December 2022, reviewed. Results: 1666 diagnosed AAA included [83.9%...
Hypercholesterolemia is a major risk factor involved in abnormal cardiovascular events. Rho-kinase–mediated Ca 2+ sensitization of vascular smooth muscle (VSM) plays critical role vasospasm and hypertension. We recently identified sphingosylphosphorylcholine (SPC) Src family tyrosine kinase (Src-TK) as upstream mediators for the sensitization. Here we report strong linkage between cholesterol VSM mediated by novel SPC/Src-TK/Rho-kinase pathway both humans rabbits. The extent correlated well...
Cell-based angiogenesis is a promising treatment for ischemic diseases; however, the survival of implanted cells impaired by oxidative stress in microenvironment. We tested hypothesis that hypoxic preconditioning enhances their resistance against stress, increasing cell and angiogenic potency after implantation into tissue. Mouse peripheral blood mononuclear (PBMNCs) were collected subjected to culture 24 h 2% O(2) at 33 degrees C. Hypoxic PBMNCs increased expression various genes related...
Background: Hypoxic preconditioning of bone marrow cells (BMCs) from young healthy individuals can enhance the cells' therapeutic potential. Considering that response to hypoxia may differ according quality cells, we assessed effect hypoxic on BMCs aged mice and compared difference in between mice. Methods Results: (3 months) (20-22 were subjected by culture for 24h 2% O2. Compared with mice, those showed significantly fewer CD34- or c-kit-positive stem higher expression p53, lower...
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease that associated with persistent inflammation and extracellular matrix degradation. The molecular mechanisms underlying the macrophage-mediated progression of AAA remain largely unclear.We show focal adhesion kinase (FAK) expression activity are enhanced in macrophages recruited to tissue. FAK potentiates tumor necrosis factor-α-induced secretion matrix-degrading enzymes chemokines by cultured macrophages. also promotes...
Primary infected aneurysms of the abdominal aorta and iliac arteries are potentially life-threatening. However, because rarity disease, its pathogenesis optimal treatment strategy remain poorly defined.A nationwide retrospective cohort study investigated patients who underwent surgical for a primary aortic and/or common artery (CIA) aneurysm between 2011 2017 using Japanese clinical registry. The evaluated relationships preoperative factors postoperative outcomes including 90-day 3-year...
Abdominal aortic aneurysm (AAA) is a common disease caused by segmental weakening of the walls and progressive dilation leading to eventual rupture aorta. Currently no biomarkers have been established indicate status AAA. Tenascin‐C (TN‐C) matricellular protein that synthesized under pathological conditions. In current study, we related TN‐C expression clinical course histopathology AAA investigate whether pattern could We found matrix metalloproteinase (MMP)‐9 were highly expressed in human...
Our objectives were to elucidate the pathophysiology of leg edema in immobile patients and discuss reasonable management this condition.The 30 with had visited our clinic between April 2009 March 2013; they suffered from severe gait disturbance, no significant venous abnormalities detected using duplex ultrasound, did not have any systemic diseases that could cause edema. Here, we review their symptoms, examinations, treatments. Among 59 edematous legs patients, (51%) symptoms indicated...
Objective: To investigate skin, subepidermal low echogenic band (SELEB), and subcutaneous tissue (SCT) thickness as well the degree of increase in echogenicity (SEG) echo-free space (SEFS) arms with lymphedema (LE). Materials Methods: The skin SCT both 30 patients unilateral stage II breast cancer-related LE were scanned at five points (medial/lateral upper arm/forearm dorsum hand). SEG SEFS grades determined according to severity (range: 0-2). Results: All measured parameters, except medial...