A5035174732- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Anorectal Disease Treatments and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Colorectal Cancer Screening and Detection
- Trigeminal Neuralgia and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ocular Diseases and Behçet’s Syndrome
- Stoma care and complications
- Facial Nerve Paralysis Treatment and Research
- Diverticular Disease and Complications
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Treatment and Pharmacology
- Cell Adhesion Molecules Research
- Multiple and Secondary Primary Cancers
- Gastrointestinal disorders and treatments
- Neurosurgical Procedures and Complications
- Lung Cancer Treatments and Mutations
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
Kanagawa Cancer Center
2019-2024
Seirei Hamamatsu General Hospital
2024
Kanagawa Prefectural Hospital Organization
2019-2024
Yokohama City University
2019-2023
Showa University Fujigaoka Hospital
2015-2022
Yokohama City University Medical Center
2021-2022
Kamituga General Hospital
2020
Tokyo Zoological Park Society
2018
Shizuoka Cancer Center
2014-2015
Social Insurance Yokohama Central Hospital
2013
✓The response of nonfluorescing infiltrating tumors that had been exposed to 5–aminolevulinic acid and irradiated using a laser at wavelength 405 nm was analyzed intraoperatively spectroscopy. Histological analyses demonstrated neoplastic cells were present in the tissue region displayed peak 636 nm, whereas no exhibited only excitation light peak. The authors conclude intraoperative use spectroscopy can allow diagnosis tumor detection boundaries infiltrate when standard fluorescence techniques fail.
Urokinase‐type plasminogen activator (uPA) binds with high affinity to its specific cell surface receptor (uPAR) (CD87) via a well‐defined sequence within the N‐terminal region of uPA (uPA 19–31 ). Since this uPA/uPAR‐interaction plays significant role in tumor invasion and metastasis, it has become an attractive therapeutic target. Two small peptidic cyclic competitive antagonists have been developed, based on uPAR binding site uPA: WX‐360 (cyclo 21,29 [ D ‐Cys21]‐uPA 21–30 [S21C;H29C])...
Coronavirus disease 2019 (COVID-19) vaccines are effective in reducing the prevalence of this disease. However, some patients develop autoimmune diseases after vaccination. We herein report a case elderly onset intestinal Behçet's (BD) with trisomy 8 following COVID-19 vaccination which was exacerbated by infection. The patient developed refractory stomatitis and genital ulcers two weeks receiving second presented bloody stool years later. Intestinal BD 8, COVID-19, treated high-dose...
Raman spectroscopy yields precise information, not only regarding the secondary structure of proteins but also discrimination between normal and malignant tissues. There is, however, no standard measurement method. We evaluated use a miniaturized, handheld, all-in-one spectrometer with 1064-nm laser excitation source for diagnosis colorectal cancer. The ultimate goal is real-time, in vivo diagnosis.Tissue samples were obtained from 20 patients who underwent surgery irradiated portable...
It is often difficult to evaluate the results of transcranial motor-evoked potential (TCMEP) monitoring in patients under general anesthesia because these are strongly affected by anesthetics and muscle relaxants. To exclude effects relaxants on TCMEP, compound action (CMAP) supramaximum stimulation median nerve immediately after (300 600 V) was recorded 70 neurosurgical operations. A relative amplitude index (RAI) defined as TCMEP operative procedure divided before procedure. The RAI...
Abstract mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression cancer cells affects tumor biologically relevant processes. In present study, individual cell clones displaying low vs. high expression were analyzed demonstrating that leads to reduced adhesion and invasion a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found be strongly upregulated overexpressing compared vector control...
Background: Resection of the primary lesion with radical lymph node dissection is most promising treatment avenue for patients cancer. On other hand, these procedures often induce excessive intraoperative blood loss (IBL) and require perioperative transfusion. The influence IBL on long-term postoperative outcomes digestive cancer controversial. We investigated impact survival recurrence after curative surgery in colorectal (CRC) a single study group. Patients Methods: In total, 1,597 who...
Background/Aim: Tumor microenvironments consist of many types immune cells, in which regulatory T-cells (Tregs) are supposed to play important roles suppress anti-tumor immunity. Regional lymph nodes essential for antitumor immunity colorectal cancer (CRC). In this study, we compared the diversity phenotypes normal tissue and regional order determine immunosuppressive mechanism node metastasis CRC. Patients Methods: Fifty patients were enrolled paired samples (tumor tissue, three as well...
Background/Aim: Population aging results in increasing numbers of elderly persons undergoing surgery for colorectal cancer. We sought to identify objective preoperative indicators outcomes, with a view toward development safe, effective treatments such patients. Patients and Methods: The study included 99 patients aged 80 years or more, who were treated surgically stage I– III Preoperative nutritional status was compared retrospectively between those suffered postoperative complications...
Background/Aim: Postoperative complications are associated with increased recurrence in colorectal cancer (CRC). We investigated the impact of infectious on CRC and overall survival after curative surgery a single study group. Patients Methods: In total, 1,668 patients who underwent radical resection for Yokohama City University, Minami Kyosai Hospital, Kanagawa Cancer Center between 2011 2019 were reviewed. classified into those (IC group) without (Non-IC group). The risk factors...
Accurate measurement of the distal rectal tumor margin is essential in selecting appropriate surgical procedure. However, there no standard method. The National Cancer Institute consensus group recommends use anal verge (AV) as a landmark, and European Society Gastrointestinal Abdominal Radiology anorectal ring (ARR). In addition, whether measurements should be made on double contrast barium enema (BE) radiographs or magnetic resonance (MR) images remains controversial. We measured both BE...
Background/Aim: We investigated the impact of Beppu9s nomogram on colorectal liver metastasis in patients receiving perioperative chemotherapy and/or targeted therapy. Patients and Methods: This study included 43 who underwent primary hepatic resection for at Kanagawa Cancer Center from June 2006 to March 2011. The were classified as having a score ≤9 (low-risk group) or ≥10 (high-risk group). risk factors disease-free survival (DFS) identified. Results: respective DFS rates 1, 2, 3 years...
Secondary mutation of mutated RAS, induced by chemotherapy, is thought to be rare. However, introduction liquid biopsy (LB) has made it possible monitor RAS status in patients' plasma throughout the course chemotherapy for metastatic colorectal cancer (mCRC), and disappearance (RAS-mt), i.e., NeoRAS-wt phenomenon, been reported receiving attention, especially with respect treatment implications.A prospective study 129 patients undergoing mCRC (RAS-wt, n=65; RAS-mt, n=64) was carried out....
To treat dental disorders and estimate age, it is important that veterinarians understand teeth eruption sequence for the animal in question. Few images of eastern grey kangaroo have been published. In present study, radiographic imagings 29 kangaroos, ranging age from 12 months to 10 years 9 months, was used surveil replacement premolars molars. These revealed patterns five stages, while second third deciduous were shed non-systematically. Furthermore, fourth molars erupted mandible earlier...
Background/Aim: The chemokine receptors C-X-C receptor type 4 (CXCR4) and C-C 7 (CCR7) play an important role in the invasion metastasis of cancer. This study investigated relationship between relative expression CXCR4 CCR7 mRNA, clinicopathological factors, outcomes patients with colorectal cancer (CRC). Patients Methods: We studied 202 who underwent surgery for CRC. levels mRNA cancerous tissue were measured using quantitative real-time reverse-transcriptase polymerase chain reaction....