A5038198190- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Synthesis and Biological Evaluation
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Chemokine receptors and signaling
- Immune cells in cancer
- Retinal and Optic Conditions
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Pulmonary Hypertension Research and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Asthma and respiratory diseases
Shionogi (Japan)
2008-2024
Futaba (Japan)
2008-2024
Osaka University
2022-2024
Seirei Hamamatsu General Hospital
2024
Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) are abundant in tumor tissues. Here, hypothesizing that Tregs would clonally expand after they activated by tumor-associated antigens to suppress antitumor immune responses, we performed single-cell analysis on characterize them cell receptor clonotype and gene-expression profiles. We found multiclonal present tissues predominantly expressed the chemokine CCR8. In mice humans, CCR8+ constituted 30 80% of various cancers less than 10%...
Abstract Topical application of imiquimod ( IMQ ), a T oll‐like receptor TLR )7 ligand, can induce and exacerbate psoriasis, chronic inflammatory skin disorder. In mouse model ‐induced psoriasis‐like inflammation, ‐helper h)17 cells interleukin IL )‐17/ ‐22‐producing γδ‐ have been shown to play pivotal role. However, the mechanisms induction h17 pathway development inflammation by treatment remain unclear. this study, we investigated pathogenic in mice. We first confirmed that, together with...
Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain homeostasis. Tregs also promote cancer progression are involved in resistance to checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ have been indicated as a possible new target of immunotherapy. Here, we investigated features lung patients. were highly activated infiltration tumors was associated with poor prognosis We their suppressive...
Although regulatory T cells (Treg) are inhibitory immune that essential for maintaining homeostasis, Tregs infiltrate tumor tissue promote growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating is, therefore, expected to activate immunity without affecting homeostasis. We previously reported selective Treg depletion targeted a C-C motif chemokine receptor 8 (CCR8) resulted in induction strong any obvious autoimmunity mouse models. Thus, herein, we developed novel...
Regulatory T cells (Tregs) contribute to the formation of a tumor-immunosuppressive microenvironment. CCR8 is reportedly selectively expressed in tumor Tregs, and an anti-CCR8 Ab can exert potent antitumor effects by eliminating intratumor Tregs murine models. In this study, we analyzed changes immunity after administration, especially CD8+ cells, which are involved cancer cell killing, using CT26 colorectal carcinoma mouse model. Immunophenotyping tumor-infiltrating mass cytometry...
Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development novel cancer anticipated. In preliminary studies, we demonstrated that tetracyclines enhanced T-cell responses. herein investigated efficacy on antitumor responses by human peripheral T cells, murine models, and lung tumor tissues non-small cell (NSCLC), focus signaling pathways in cells.
Abstract Background CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8 + Tregs their interaction with CD8 in the tumor microenvironment human lung cancer. We evaluated spatial distribution impact cell effector function, specifically granzyme B (GzmB) expression, clinical outcomes. Methods A total 81 patients squamous carcinoma (LSCC) who underwent radical...
Coronavirus disease 2019 (COVID-19) vaccines are effective in reducing the prevalence of this disease. However, some patients develop autoimmune diseases after vaccination. We herein report a case elderly onset intestinal Behçet's (BD) with trisomy 8 following COVID-19 vaccination which was exacerbated by infection. The patient developed refractory stomatitis and genital ulcers two weeks receiving second presented bloody stool years later. Intestinal BD 8, COVID-19, treated high-dose...
DNA methylation is a pivotal epigenetic modification that defines cellular identity. While cell deconvolution utilizing this information considered useful for clinical practice, current methods are limited in their accuracy and resolution. In study, we collected data from 945 human samples derived various tissues tumor-infiltrating immune cells trained neural network model with them. The model, termed MEnet, predicted abundance of population together the detailed status bulk data, showed...
The Kv1.3 voltage-gated potassium channel is selectively upregulated upon activation in effector memory T (TEM ) cells inflamed tissue, and plays an important role maintenance of T-cell activation. Although blockers have been shown to ameliorate allergic contact dermatitis (ACD) a rat model, it remains unknown whether the effect on ACD mediated by suppressing TEM cell function and/or naive T-cells or central (TCM are influenced.To analyse detailed mechanism model ACD.We examined effects...
Abstract Background CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8 + Tregs their interaction with CD8 in the tumor microenvironment human lung cancer. We evaluated spatial distribution impact cell effector function, specifically granzyme B (GzmB) expression, clinical outcomes. Methods A total 81 patients squamous carcinoma (LSCC) who underwent radical...
Inhibiting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-mediated immune checkpoint system using an anti-CTLA-4 antibody (Ab) can suppress growth of various cancers, but detailed mechanisms are unclear. In this study, we established a monoclonal hepatocellular carcinoma cell line (Hepa1-6 #12) and analyzed associated with Ab treatment. Depletion CD4 + T cells, not CD8 prevented Ab-mediated anti-tumor effects, suggesting dependence on cells. Anti-CTLA-4 treatment resulted in...
<p>In vivo anti-tumor activity of S-531011 in CT26.WT or EMT6 tumor-bearing mice model.</p>
<p>The binding activity of S-531011 against various chemokine receptors, PD-1, PD-L1, CTLA4, or mouse CCR8</p>
<p>Concentration of S-531011 in serum and tumor after a single intravenous administration CT26.WT tumor-bearing hCCR8 KI mice.</p>
<div>Abstract<p>While regulatory T cells (Tregs) are inhibitory immune that essential for maintaining homeostasis, Tregs infiltrate tumor tissue promote growth by suppressing anti-tumor immunity. Selective reduction of tumor-infiltrating is therefore expected to activate immunity without affecting homeostasis. We previously reported selective Treg depletion targeted a C-C motif chemokine receptor 8 (CCR8) resulted in induction strong any obvious autoimmunity mouse models. Thus,...
<p>Supplementary Information</p>
<p>Concentration of S-531011 in serum and tumor after a single intravenous administration CT26.WT tumor-bearing hCCR8 KI mice.</p>
<p>Binding profile of the newly created CCR8 antibody</p>