A5048527314- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Synthesis and Biological Evaluation
- Photosynthetic Processes and Mechanisms
- Platelet Disorders and Treatments
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Congenital heart defects research
- Complement system in diseases
- Liver Disease Diagnosis and Treatment
- Reproductive Health and Technologies
- Pluripotent Stem Cells Research
- Plant Reproductive Biology
- Plant Parasitism and Resistance
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Plant Molecular Biology Research
- Renal and related cancers
- Assisted Reproductive Technology and Twin Pregnancy
- Protist diversity and phylogeny
- Cholesterol and Lipid Metabolism
- Geological and Geophysical Studies
- Calcium Carbonate Crystallization and Inhibition
Shionogi (Japan)
2018-2023
Futaba (Japan)
2018-2020
Osaka University of Pharmaceutical Sciences
2013
The University of Tokyo
1993-2012
Osaka University
1988-2006
Osaka Red Cross Hospital
2004
Tokyo Medical and Dental University
2003
Gunma University
2001
Osaka Health Science University
1981
Although regulatory T cells (Treg) are inhibitory immune that essential for maintaining homeostasis, Tregs infiltrate tumor tissue promote growth by suppressing antitumor immunity. Selective reduction of tumor-infiltrating is, therefore, expected to activate immunity without affecting homeostasis. We previously reported selective Treg depletion targeted a C-C motif chemokine receptor 8 (CCR8) resulted in induction strong any obvious autoimmunity mouse models. Thus, herein, we developed novel...
In the cytoplasmic layer that faces outer periclinal wall in epidermal cells of leaves aquatic angiosperm Vallisneria gigantea Graebner, we examined a possible interrelationship among configuration microfilaments, chloroplast motility, and anchoring chloroplasts. dark-adapted cells, microfilaments are arranged network array. During 10-min incubation darkness 10 to 20 min after irradiation with red light (650 nm, 0.41 W m−2) for 5 min, number containing array decreased substantially while...
In mesophyll cells of Vallisneria gigantea Graebner, an aquatic angiosperm, the association plasma membrane with cell wall at end has been reported to be indispensable for mechanism that maintains stationary organization bundles microfilaments (MFs) [Masuda et al. (1991) Protoplasma 162: 151]. To identify putative extracellular components might play a crucial role in this mechanism, we examined effects two exogenously applied synthetic hexapeptides, GRGDSP and ARYDEI, which include RGD RYD...
Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. 18F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (18F-FPP-RGD2) has been used as PET probe for tumors expressing αvβ3. The aim of this study was to assess the potential with 18F-FPP-RGD2 detect αvβ3 expression non-alcoholic steatohepatitis (NASH) model mice.Thirty-two male C57BL/6 mice aged 6 weeks were fed choline-deficient, L-amino acid-defined,...
The spermatogonial transplantation experiment can be used as an unequivocal detection assay of spermatogenic stem cells (SSCs) in both a qualitative and quantitative manner, based on their regenerative capacity. In this study, the proliferative patterns kinetics donor-derived GFRα1-positive spermatogonia containing potential SSCs were examined during early colonization following transplantation.Donor-derived frequently formed several aggregates A(al(aligned)) /morula-like structures single...
Familial platelet disorder (FPD) is a rare autosomal dominant disease characterized by thrombocytopenia and abnormal function. Causal mutations have been identified in the gene encoding runt-related transcription factor 1 (RUNX1) of FPD patients.To elucidate role RUNX1 regulation expression 4 (PF4) to propose plausible mechanism underlying RUNX1-mediated induction phenotype.We assessed whether its mutants, combination with E26 transformation-specific-1 (ETS-1), Core-binding subunit beta...