A5041011471- Inflammatory Bowel Disease
- Microscopic Colitis
- Cytomegalovirus and herpesvirus research
- Esophageal and GI Pathology
- Mycobacterium research and diagnosis
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Heat shock proteins research
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Viral-associated cancers and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- IL-33, ST2, and ILC Pathways
- Gastroesophageal reflux and treatments
Kansai Medical University
2022-2025
Kyoto University
2014-2024
Kyoto University Hospital
2020-2022
Genetic Analysis (Norway)
2014
Background and AimsUlcerative colitis is the most frequent type of inflammatory bowel disease characterized by colonic epithelial cell damage. Although involvement autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies have yet to be elucidated.MethodsUsing 23 recombinant integrin proteins, we performed enzyme-linked immunosorbent assays on sera from patients with controls. Integrin expression IgG binding colon tissues controls were examined using...
Abstract Lipocalin 2 (Lcn2), also called neutrophil gelatinase B-associated lipocalin (NGAL), is an anti-microbial peptide originally identified in granules. Although Lcn2/NGAL expression increased the inflamed intestinal tissues of patients with inflammatory bowel disease, role development inflammation remains unclear. Here we investigated using a spontaneous mouse colitis model, interleukin-10 knock out (IL-10 KO) mice. Lcn2 colonic IL-10 KO mice colitis. Lcn2/IL-10 double-KO showed more...
Tacrolimus is a novel immunomodulator for inflammatory bowel diseases. Immunosuppressive effects of tacrolimus on T cells are well known; however, the macrophages remain unclear. The aim this study was to investigate activated and examine its efficacy in murine colitis models.Proinflammatory cytokine production from lipopolysaccharide (LPS)-stimulated peritoneal IL-10-knockout (KO) mice with without measured. We investigated nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK),...
<h3>Objective</h3> Intestinal fibrosis is a clinically important issue in Crohn9s disease (CD). Heat shock protein (HSP) 47 collagen-specific molecular chaperone involved fibrotic diseases. The mechanisms of HSP47 induction intestinal related to CD, however, remain unclear. Here we investigated the role interleukin (IL)-17A-induced expression CD. <h3>Design</h3> Expressions and IL-17A tissues patients with IBD were determined. collagen I expressions assessed subepithelial myofibroblasts...
Abstract Background Janus kinase inhibitors (JAKis) have revolutionized ulcerative colitis (UC) management; however, the consequences of treatment discontinuation in patients achieving clinical remission remain poorly understood. This study investigated outcomes following JAKi and retreatment effectiveness with relapse. Methods In this multicenter retrospective cohort study, we analyzed 101 UC who received their first between 2018 2024. Among them, 53 achieved (Patient-Reported Outcome 2=0)...
Treatment of severe ulcerative colitis (UC) is challenging. Although the efficacy tacrolimus (TAC) and infliximab (IFX) have been evaluated in patients with UC, safety levels sequential therapies (TAC→IFX/IFX→TAC) these remain unclear. The aim this study was to assess short-term long-term outcomes UC treated TAC IFX.From October 2001 February 2014, 29 consecutive or IFX were retrospectively evaluated. Median follow-up duration 27 months (range 0.5-118 months). primary end point at 8 weeks...
Early-stage gastric cancer (EGC) found after Helicobacter pylori (Hp) eradication is often difficult to diagnose using conventional white light (WL) endoscopy. We aimed evaluate whether Texture and Color Enhancement Imaging (TXI), a new image-enhanced endoscopy enhances the EGC lesions Hp eradication. also compared diagnostic accuracy lesion detection time between WL TXI in trainee endoscopists. 58 successful were enrolled. Using endoscopic images WLI, mode 1 (TXI1), 2 (TXI2), visibility of...
Heparan sulfate (HS), a constituent of HS proteoglycans (HSPGs), is linear polysaccharide present on the cell surface. HSPGs modulate functions several growth factors and signaling molecules. We examined whether small intestinal epithelial plays some roles in crypt homeostasis using epithelium (IEC)-specific HS-deficient C57Bl/6 mice. Survival rate after total body irradiation was significantly reduced mice due to profound injury. IECs exhibited Wnt/β-catenin pathway disruption, decreased...
Background: Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some patients, despite fact that CMV-DNA colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies for patients concomitant with CMV are required. Aims: The aim of this study was evaluate effect and safety granulocyte-monocyte adsorption apheresis (GMA) positive Methods: From October...
The long-term efficacy of infliximab (IFX) for patients with refractory ulcerative colitis (UC) is unclear. aim this study was to assess the outcomes IFX treatment in UC. Thirty-three UC who received at Kyoto University Hospital between 2003 and 2013 were retrospectively evaluated. intensification defined as a dose escalation (up 10 mg/kg) and/or shorter intervals infusions (every 4–6 weeks). Of 33 scheduled IFX, 24 (72.7%) achieved clinical remission within 8 weeks after initiating...
Background Osteopontin (OPN) is a multifunctional protein expressed in variety of tissues and cells. Recent studies revealed increased OPN expression the inflamed intestinal patients with inflammatory bowel disease (IBD). The role pathophysiology IBD, however, remains unclear. Aims To investigate development inflammation using murine model interleukin-10 knock out (IL-10 KO) mice. Methods We compared colitis between IL-10 KO OPN/IL-10 double (DKO) colonic mice was examined by fluorescence...
Monoclonal antibodies have accelerated the availability of treatment options for many diseases in which molecular mechanism has been elucidated detail. Therefore, an assay that can universally analyze clinical pharmacokinetics and cross-sectional studies would be indispensable. We developed a universal antibody bioanalysis with Fab-selective tryptic reaction, named nano-surface molecular-orientation limited (nSMOL) proteolysis, collects specific signature peptides biological samples. Using...
Little is known about the efficacy and safety of infliximab for ulcerative colitis refractory to tacrolimus. The aim this study was evaluate in induction remission patients with persistent symptoms despite tacrolimus therapy.We report a retrospective, observational, single-center case series 12 consecutively enrolled that received therapy remission. Eight single infusion infliximab, four two or more infusions. Median follow-up duration 16.0 months (range, 1.6-41.4 months). clinical response...
Background Endoscopic balloon dilation is a promising procedure to improve symptoms of intestinal stricture in patients with C rohn's disease ( CD ). However, the long‐term efficacy endoscopic combined immunomodulatory drugs remains unclear. The aim present study investigate whether prior use affects clinical outcome for . Patients and Methods Between J anuary 2004 D ecember 2011, 83 dilations were carried out 25 Median follow‐up period was 46 months. categorized into two groups based on...
Human cytomegalovirus (HCMV) infection is considered to be an exacerbating factor in patients with ulcerative colitis (UC). However, the pathogenicity of HCMV exacerbation UC remains unclear. The lack a model mimicking has posed challenge for research into pathogenic mechanism flare UC. Therefore, aim our study was establish new mouse infection. We established latent murine CMV (MCMV) T-cell receptor α knockout (TCR-α KO) mice at early age by adjustment viral dose. Next, we performed...
Rationale: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized chronic diarrhea, liver disease, hair abnormalities, high mortality early childhood due to severe infection cirrhosis. Patient concerns: The patient second child of three siblings born non-consanguineous healthy Japanese parents. She had intrauterine growth retardation was delivered at 33 weeks gestation placental abruption. presented with watery elevated...
A 75-year-old man was admitted to our hospital with sudden onset of vomiting and abdominal distension. The patient taking medication for arrhythmia. Computed tomography showed stenosis the ileum a small bowel dilatation on oral side from region stenosis. transnasal ileus tube placed. Enteroclysis using contrast medium revealed an approximately 6-cm afferent tubular 10 cm terminal thumbprinting in proximal bowel. Transanal double-balloon enteroscopy circumferential shallow ulcer smooth margin...
Background/Aims The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission thiopurine are unclear. aim this study was to assess the efficacy and safety maintenance treatment in UC patients. Methods This a retrospective observational cohort analysis conducted at single center. Between December 1998 August 2013, 59 87 achieved after induction treatments other than biologics were enrolled. Remission defined as no concomitant needed...