A5017987162- Inflammatory Bowel Disease
- Microscopic Colitis
- Exercise and Physiological Responses
- Gastric Cancer Management and Outcomes
- Muscle metabolism and nutrition
- Epigenetics and DNA Methylation
- Sports Performance and Training
- Autoimmune and Inflammatory Disorders
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Sarcoma Diagnosis and Treatment
- Thermoregulation and physiological responses
- Liver Diseases and Immunity
- Bone Tumor Diagnosis and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Metastasis and carcinoma case studies
- Vitamin D Research Studies
- Vascular Tumors and Angiosarcomas
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Electrochemical Analysis and Applications
Taisho Pharmaceutical (Japan)
2022-2024
Kyoto University
1999-2023
Ono Pharmaceutical (Japan)
2023
Nagoya City University
2014-2020
Hamamatsu University School of Medicine
2019-2020
Nagaoka Red Cross Hospital
2008-2016
Johns Hopkins Hospital
2013
The University of Texas MD Anderson Cancer Center
2013
National Institute of Mental Health and Neurosciences
2013
Columbia University
2013
Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but molecular requirements for such homeostatic IgA remain unknown. We found that a heavily glycosylated monoclonal recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), prominent symbiont phylum Bacteroidetes. In vivo, alters expression polysaccharide utilization loci (PUL), including functionally uncharacterized family provisionally named Mucus-Associated Functional Factor...
Visible-light-derived O2 production was yielded by conjugating water oxidation catalysis [(OH2)(terpy)Mn(μ-O)2Mn(terpy)(OH2)]3+ as an oxygen evolving center model and photo-sensitization of [Ru(bpy)3]2+ a photoexcitation at interlayer mica.
There has been increased interest in the role of B cells pathogenesis primary biliary cirrhosis (PBC). Although vast majority patients with this disease have anti-mitochondrial antibodies, there is no correlation antibody titer and/or presence severity. Furthermore, murine models PBC, it suggested that depletion may exacerbate pathology. To address issue, we focused on a detailed phenotypic characterization mononuclear cell infiltrates surrounding intrahepatic bile ducts sclerosing...
Treatment of severe ulcerative colitis (UC) is challenging. Although the efficacy tacrolimus (TAC) and infliximab (IFX) have been evaluated in patients with UC, safety levels sequential therapies (TAC→IFX/IFX→TAC) these remain unclear. The aim this study was to assess short-term long-term outcomes UC treated TAC IFX.From October 2001 February 2014, 29 consecutive or IFX were retrospectively evaluated. Median follow-up duration 27 months (range 0.5-118 months). primary end point at 8 weeks...
Previously, it has been shown that integrin α6β1 expressed on human granulosa cells regulates luteinization in co-operation with its ligand, laminin. In this study, α2 was immunohistochemically demonstrated to be and large luteal cells. It also detected luteinizing theca interna after ovulation. Immunoreactive collagen type IV, which is one of the ligands for α2β1, around pre-ovulatory follicles expression rapidly increased during By flow cytometry, IV cell surface isolated from follicles,...
The long-term efficacy of infliximab (IFX) for patients with refractory ulcerative colitis (UC) is unclear. aim this study was to assess the outcomes IFX treatment in UC. Thirty-three UC who received at Kyoto University Hospital between 2003 and 2013 were retrospectively evaluated. intensification defined as a dose escalation (up 10 mg/kg) and/or shorter intervals infusions (every 4–6 weeks). Of 33 scheduled IFX, 24 (72.7%) achieved clinical remission within 8 weeks after initiating...
Background Osteopontin (OPN) is a multifunctional protein expressed in variety of tissues and cells. Recent studies revealed increased OPN expression the inflamed intestinal patients with inflammatory bowel disease (IBD). The role pathophysiology IBD, however, remains unclear. Aims To investigate development inflammation using murine model interleukin-10 knock out (IL-10 KO) mice. Methods We compared colitis between IL-10 KO OPN/IL-10 double (DKO) colonic mice was examined by fluorescence...
Despite the known beneficial effects of creatine in treating exercise-induced muscle damage (EIMD), its effectiveness remains unclear. This study investigates recovery effect monohydrate (CrM) on EIMD. Twenty healthy men (21-36 years) were subjected to stratified, randomized, double-blind assignments. The (CRE) and placebo (PLA) groups ingested crystalline cellulose, respectively, for 28 days. They subsequently performed dumbbell exercises while emphasizing eccentric contraction elbow...
Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than the general population Western studies. However, actual state of VTE Asian IBD remains poorly understood. Aims: To reveal incidence patients Japan. Methods: Eighty-five admitted 3 gastroenterology centers were registered from 2013 2018. The with (n = 42) was prospectively compared that among other digestive diseases 43). presence surveyed using contrast-enhanced computed...
Several reports have indicated a possible link between decreasing plasma levels of vitamin K and bone mineral density. It has been suggested that intestinal bacteria contribute to maintenance K. factors are involved in the reduction patients with Crohn's disease (CD). We aimed assess relationship gut microbiota alternative indicators deficiency CD. collected feces 26 clinically inactive extracted 16S rRNA from amplified it by polymerase chain reaction. The generated reaction product was...
Abstract Pathological staging and histological grading systems are useful, but imperfect, predictors of recurrence in head neck squamous cell carcinoma (HNSCC). Aberrant promoter methylation is the main type epigenetic modification that plays a role inactivation tumor suppressor genes. To identify new potential prognostic markers, we investigated status five neuropeptide receptor The target genes was compared with clinical characteristics 278 cases; 72 hypopharyngeal cancers, 54 laryngeal 75...
Ten-eleven translocation (TET) enzymes are implicated in DNA demethylation through dioxygenase activity, which converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC). However, the specific roles of TET and 5-hmC levels head neck squamous cell carcinoma (HNSCC) have not yet been evaluated. In this study, we analyzed mRNA expression a well-characterized dataset 117 matched pairs HNSCC tissues normal tissues. were examined via enzyme-linked immunosorbent assay quantitative real-time PCR,...
Abstract: The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and 2013, 179 were treated at eleven hospitals. Twenty consecutive (11.2%) developed metastases initial treatment primary extremities. We investigated 20 metastasis. There 14 males six females a mean age 49 years. duration between surgery appearance was 34 months. follow-up period 48 excluded time presentation from this study. At final follow-up,...
A photosynthetic photosystem II (PS II) model was developed by adsorbing [(OH2)(terpy)MnIII(μ-O)2MnIV(terpy)(OH2)]3+ (1, terpy = 2,2′:6′,2′′-terpyridine) as an oxygen evolving center and Ru(bpy)32+ (bpy 2,2′-bipyridine) a photoexcitation onto mica. The mica adsorbates were prepared three different methods; Adsorbate adsorption of 1 followed on mica, Adsorbates B C the opposite order co-adsorption Ru(bpy)32+, respectively. UV-visible diffuse reflectance (DR) spectroscopic data emission decay...
Background/Aims The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission thiopurine are unclear. aim this study was to assess the efficacy and safety maintenance treatment in UC patients. Methods This a retrospective observational cohort analysis conducted at single center. Between December 1998 August 2013, 59 87 achieved after induction treatments other than biologics were enrolled. Remission defined as no concomitant needed...
Eccentric exercise induces muscle damage and inflammation, resulting in a state of reduced physical activity with dysfunction feeling tiredness after exercise. Creatine is known to act as an energy buffer, but it has also been suggested exert inhibitory effects on peripheral inflammation. The purpose this study was test the hypothesis that creatine supplementation alleviates fatigue eccentric explore mechanism effect. C57BL/6J mice were fed AIN-93G-formulated control diet or...
Abstract Background Single nucleotide polymorphisms (SNPs) of the MEFV gene may modify inflammatory bowel disease (IBD) activity. The prevalence SNPs in IBD patients and their involvement pathophysiology remains unclear. Methods We analyzed 12 peripheral leukocytes Japanese (Crohn’s [CD]: 69 patients, ulcerative colitis: 32 patients) by polymerase chain reaction using next-generation DNA sequencing evaluated association with characteristics. Inflammasome activity mature interleukin (IL)-1β...