A5054249950- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Liver Diseases and Immunity
- DNA Repair Mechanisms
- Liver Disease and Transplantation
- Genomics, phytochemicals, and oxidative stress
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- TGF-β signaling in diseases
Niigata University
2012-2022
Niigata University Medical and Dental Hospital
2007-2021
RMIT University
2008-2013
Kiel University
2011
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
2011
National and Kapodistrian University of Athens
2011
University of Dental Medicine
2011
It has been reported that the presence of anti‐nuclear antibody against a 210kDa glycoprotein nuclear pore complex (anti‐gp210) is highly specific for primary biliary cirrhosis (PBC). The aim present study was to investigate significance anti‐gp210, especially as prognostic marker. anti‐gp210 ascertained in 113 patients with PBC and 162 controls by indirect immunofluorescence assay using HepG2 cells immunoblotting analysis extracts from HeLa cells. Anti‐gp210 detected 25 (22.1%) patients. None...
Administration of dextran sulphate sodium to animals induces acute colitis characterized by infiltration large numbers neutrophils into the colonic mucosa, which histologically resembles human active ulcerative colitis. It has been reported that and reactive oxygen metabolites produced them are involved in progress This study was intended clarify their roles using this animal model. First, possible sources species were determined luminol-dependent chemiluminescence with addition enzyme...
Abstract: Background: Dysregulation of cell proliferation is one the most important features human cancers including hepatocellular carcinoma (HCC). However, molecular basis underlying HCC has not been fully clarified. Because a previous study reported that overexpression extracellular signal‐regulated protein kinase (ERK), which transduces growth stimuli to nuclei, was frequently observed in several cancers, this performed analyze expression ERK and its correlation with proliferation....
There has been increased interest in the role of B cells pathogenesis primary biliary cirrhosis (PBC). Although vast majority patients with this disease have anti-mitochondrial antibodies, there is no correlation antibody titer and/or presence severity. Furthermore, murine models PBC, it suggested that depletion may exacerbate pathology. To address issue, we focused on a detailed phenotypic characterization mononuclear cell infiltrates surrounding intrahepatic bile ducts sclerosing...
Background . Phosphorylated histone H2AX ( γ -H2AX) is a potential regulator of DNA repair and useful tool for detecting damage. To evaluate the clinical usefulness -H2AX in hepatocellular carcinoma (HCC), we measured level HCC, dysplastic nodule, nontumorous liver diseases. Methods The was by immunohistochemistry fifty-eight 18 chronic hepatitis, 22 cirrhosis, 19 nodules. Appropriate cases were also examined fluorescence analysis western blotting. Results All with disease showed increased...
It is widely accepted that thrombocytopenia associated with liver cirrhosis caused by increased platelet destruction in the enlarged spleen, but this issue has not yet been analysed sufficiently terms of production. Thrombopoietin produced mainly and strongly promotes We studied serum thrombopoietin levels its mRNA tissue cirrhotic patients also a rat model cirrhosis. Furthermore, to clarify influence we investigated splenectomized rats. The level humans was significantly reduced instead...
Aim: Previous studies have revealed that functional impairment of innate immune cells, including natural killer (NK) and T (NKT) might be associated with the persistence hepatitis C virus (HCV) infection. However, involvement which predominate in liver, therapeutic HCV clearance is still unclear. Methods: To clarify role intrahepatic cells clinical outcome patients chronic (CHC) treated interferon‐α plus ribavirin (IFN/RBV), we prospectively investigated status NK NKT paired liver biopsy...
Abstract Aim Sphingosine‐1‐phosphate (S1P) and ceramide are bioactive sphingolipids known to be important in regulating numerous processes involved cancer progression. The aim of this study was determine the absolute levels hepatocellular carcinoma (HCC) utilizing data obtained from surgical specimens. In addition, we explored clinical significance S1P patients with HCC biological role cells. Methods Tumors normal liver tissues were collected 20 HCC, measured by mass spectrometry. Cancer...
Hepatic stem cells are capable of dramatically changing and differentiating to form mature hepatocytes in acute chronically damaged livers; however, the clinicopathological characteristics these heterogeneous cell populations have not been sufficiently analyzed.In this study, tissue sections from 12 cases livers 31 hepatocellular carcinomas (HCC), surrounding liver tissues, were analyzed by immunohistochemistry using previously reported hepatic stem/progenitor marker CD133 (AC133) neural...