A5009053363- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Stonefly species taxonomy and ecology
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Freshwater macroinvertebrate diversity and ecology
- Glycogen Storage Diseases and Myoclonus
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Hepatitis B Virus Studies
- Neurotransmitter Receptor Influence on Behavior
- Aquatic Invertebrate Ecology and Behavior
- Diabetes Management and Research
- Neurological disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Intestinal Malrotation and Obstruction Disorders
- Receptor Mechanisms and Signaling
- Biochemical and Molecular Research
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neural Engineering
- Neuroendocrine Tumor Research Advances
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
Teine Keijinkai Hospital
2022-2025
Musashino Red Cross Hospital
2018-2020
Kyorin University Hospital
2020
Citizen (Japan)
2017
National Cerebral and Cardiovascular Center
1990-2016
Tsubame Rosai Hospital
2015
Nippon Medical School Musashi Kosugi Hospital
2014
Toshima Hospital
2008
Kanagawa Environmental Research Center
2007
Tohoku University
2003-2005
To identify the mechanism of hyperuricemia in glycogen storage diseases (glycogenoses) that affect muscle, we studied effects exercise and prolonged rest on purine metabolism two patients with glycogenosis type III (debrancher deficiency), one patient V (muscle phosphorylase VII phosphofructokinase deficiency). All had except for III. Plasma concentrations ammonia, inosine, hypoxanthine increased markedly all after mild leg a bicycle ergometer. The plasma urate also increased, but delayed...
The differential tissue-specific regulation of glucokinase activity in liver and pancreatic islet cells was investigated the insulinoma-bearing rat. A transplantable insulinoma caused hyperinsulinemia hypoglycemia host by 2-3 months after implantation. Suppression B-cells high insulin and/or low glucose manifested itself a decrease tissue. Removal tumor initiated transient deficiency hyperglycemia with extremes these changes at 24 h resection. These conditions markedly affected...
Abstract Aim In 2019, expanded criteria for hepatocellular carcinoma (HCC), known as 5‐5‐500 (size ≤5 cm, number ≤5, alpha‐fetoprotein ≤500 ng/mL), well Model End‐stage Liver Disease (MELD) exception, were implemented in Japan. the present study, we evaluated liver transplantation indications and Japanese allocation policy HCC. Methods Adults with HCC between January 2013 December 2017 a multicenter study The patients aged ≤65 years, line limits of transplant center limits. Results ( n =...
Although insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles ischemic stroke. The purpose this study was to clarify whether are causative factors stroke.Thirty-four consecutive patients with stroke, who were normotensive, nondiabetic, not obese, classified into three groups--atherothrombotic infarction (n = 16), lacunar 10), cardioembolic 8)--based on clinical findings, brain imaging, cerebral angiography. Both...
Abstract Background and Aim Tenofovir alafenamide (TAF) is a new prodrug of tenofovir, enabling treatment patients with hepatitis B virus (HBV) infection at lower dose than tenofovir disoproxil fumarate (TDF), via more efficient delivery to the hepatocytes. We compared efficacy safety TDF TAF investigated switching from therapy. Methods Consent for therapy was obtained 117 67 August 2014 January 2018. In total, 45 14 were administered TAF, respectively, as naïve therapy, 36 switched TAF. The...
The aim of this study is to clarify the value serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon-free, direct-acting antivirals (DAAs).This a retrospective cohort that included 567 underwent antiviral an interferon-free DAA regimen and SVR. Serum WFA+ -M2BP was measured after Factors predictive HCC occurrence...
To investigate purine catabolism in exercising muscles of patients with muscle glycogen storage disease, we performed ischemic forearm exercise tests and quantitated metabolites appearing cubital venous blood. Two disease type V three VII participated this study. Basal lactate concentrations lowered every patient or VII. VII, who had markedly elevated serum uric acid (14.3 11.9 mg/dl, respectively), showed high basal ammonia (118 79 mumol/liter, respectively; 23 +/- 4 mumol/liter healthy...
Abstract Prediction of hepatocellular carcinoma ( HCC ) development after sustained virological response SVR is clinically important, and the usefulness noninvasive markers for prediction have been reported. The aim this study was to compare accuracy by markers. A total 346 patients with chronic hepatitis C without history who achieved through direct‐acting antivirals were included. Magnetic resonance elastography MRE serum fibrosis measured 12 weeks end treatment, subsequent examined. mean...
Abstract The assessment of liver fibrosis is essential because it correlates with mortality risk in nonalcoholic fatty disease (NAFLD). This study aims to examine whether serum markers could identify candidate patients likely have advanced fibrosis. We enrolled 352 NAFLD and performed biopsies 97 patients. area under the receiver operating characteristic curve (AUROC) stiffness by magnetic resonance elastography for histological was 0.910, optimal cutoff value 4.07 kPa. To predict severe...
Infrared thermography systems have been used for fever screening at many airports since the outbreak of severe acute respiratory syndrome (SARS) in 2003. However, these are expensive and non-portable. Therefore, we developed a cost-effective compact (2.9 × 5.8 2.0 cm) thermopile array patients with infectious diseases clinical setting.The was created small pixels (48 47 = 2256 pixels) fabricated on silicon wafer using microelectromechanical technology. We tested this 155 febrile afebrile...
The present study aimed to report our real-life experience of the TPO receptor agonist lusutrombopag for cirrhotic patients with low platelet counts.We studied counts in 1,760 undergoing invasive procedures at hospital between January 2014 and December 2017. In addition, we 25 who were administered before June 2017 2018. Effectiveness raise avoid transfusion treatment-related adverse events analyzed.In without prior procedures, proportion whose <50,000/μL needed transfusions 66% (n = 27/41)...
The prediction of hepatocellular carcinoma (HCC) development during nucleotide/nucleoside analog (NA) therapy is clinically important in patients with chronic hepatitis B. Although several useful models for HCC have been previously reported, their usefulness the Japanese population unclear. Therefore, this study examines applicability these patients.Four hundred forty-three no history who were treated entecavir, tenofovir alafenamide, or disoproxil fumarate enrolled. PAGE-B, modified-PAGE-B,...
Glucose usage by soluble fractions of cell extracts from two insulin-producing lines, RINm5F and HIT, was investigated. Analysis enzyme activities indicated that glucose phosphorylation phosphofructokinase are likely to be the rate-limiting steps glycolysis in both HIT extracts. extracts, which lack glucokinase, exhibited relatively flat concentration-dependency curves showed substantial inhibition hexokinase. contain glucokinase but hexokinase, sigmoidal usage,reflecting almost fully...
Type VII glycogenosis (muscle phosphofructokinase deficiency) is attended by hyperuricemia and hyperuricosuria. In one patient, we found that exercise on a bicycle ergometer increased plasma uric acid, inosine, hypoxanthine levels. Forearm also markedly venous hypoxanthine, ammonia in the exercising arm of two patients. Exaggerated release precursors for acid synthesis from muscle may be related to hyperuricemia.
Aim Elastic fiber deposition is a cause of irreversibility liver fibrosis. However, to date, its relevance clinical features has not yet been clarified. This study aimed clarify the correlation between non‐invasive markers fibrosis and quantity, including elastic fiber, obtained from computational analysis. Methods retrospective included 270 patients evaluated by assessment prior biopsy. Of these patients, 95 underwent magnetic resonance elastography (MRE) 244 were assessed with Wisteria...
Aim Lenvatinib (LEN) is a newly approved, multikinase inhibitor for treating unresectable hepatocellular carcinoma. In the present study, we investigated impact of three different criteria evaluating radiological objective response (OR) on overall survival in real‐world data. Methods Consent LEN therapy was obtained from 51 patients April 2018 to March 2019. A total 40 who received minimal cumulative duration 4 weeks were included analysis. Enhanced computed tomography scan performed at...
The effects of substance P (SP) and calcitonin gene-related peptide (CGRP) were tested on pial arterioles mice. This was done because (1) perivascular peptidergic nerves may play an important role in modulation cerebrovascular responses; (2) there are conflicting data concerning the mechanism action CGRP; (3) few or no studies directly testing endothelium dependence dilation by these peptides cerebral circulation; (4) we wished to extend previous observations mice comparing responses mouse...
A 26-year-old girl with muscle phosphorylase deficiency had exercise intolerance and experienced an occasional "second wind" phenomenon. Muscle glycogen concentration was about three times the normal level, whereas each glycolytic intermediate below step equivalent to only 10% of a level. Semi-ischemic forearm tests disclosed no elevation venous lactate or pyruvate but they showed remarkable increases serum creatine kinase ammonia. Glucagon administration markedly augmented tolerance....
Abstract Pretreatment with glucagon relieved patients McArdle disease from muscular symptoms during exercise and enhanced performance, though it did not produce any improvement in Tarui disease. The difference effect between the two diseases was clearly demonstrated bicycle ergometer tests. In addition, semi‐ischemic forearm tests performed after injection showed that increased lactate production significantly incluced by disease, but case disese, augmentation exercise‐induced also observed...
Pial arterioles of mice were monitored by intravital television microscopy. Responses to acetylcholine (ACh) and McN-A-343, a selective M1 activator, before after endothelial injury laser-dye technique in the presence or absence different reference antagonists M1, M2, M3 muscarinic receptors. ACh McN-A-343 produced endothelium-dependent dilation that was blocked 4-diphenyl-N-methyl-piperidine methiodide, an inhibitor receptor. Dilations not augmented blocking receptor with pirenzepine....