A5038687302- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- MRI in cancer diagnosis
- Gastrointestinal Tumor Research and Treatment
- Dermatological and COVID-19 studies
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Clusterin in disease pathology
Tokyo Medical University
2024-2025
Teine Keijinkai Hospital
2022-2024
Biloma is a complication of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) [1]. Despite being the first-line treatment infected bilomas, percutaneous drainage can affect daily life and pose self-extraction risks, particularly in older patients [2]. Endoscopic ultrasound (EUS)-guided offers viable alternative internal biliary drainage; however, it be challenging right liver lobe because its long distance from gastrointestinal (GI) tract [3] [4] [5]. Here,...
Background: Early detection of pancreatic cancer using existing tumor markers is challenging, and novel biomarkers are needed. Apolipoprotein A2 (APOA2), which not directly produced by tumors, may help detect through mechanisms distinct from carbohydrate antigen 19-9 (CA 19-9). This study aimed to evaluate the diagnostic performance APOA2-isoform (APOA2-i) Index in patients with cancer. Methods: Serum levels APOA2-i CA were measured 76 (Stage 0, n = 5; I, 4; II, 15; III, 19; IV, 33) 98...
Although covered self-expandable metal stents (CSEMSs) are associated with the risk of postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis due to pancreatic duct (PD) orifice obstruction, they often used for biliary drainage treatment in malignant obstruction (MBO). This study aimed investigate efficacy PD stenting preventing post-ERCP after CSEMS implantation.This retrospective cohort analyzed 554 patients transpapillary MBO. Patients noninitial deployment, benign...
Abstract Objective Few reports have explored the application of urinary trypsinogen‐2 measurement in early diagnosis post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and none demonstrated benefits noninvasive testing. This study aimed to evaluate clinical rapid dipstick test (Nipro, Japan) compared with serum amylase lipase levels for post‐ERCP pancreatitis (PEP). Methods A total 100 consecutive patients (54 men 46 women) who were admitted underwent ERCP at Tokyo...
Walled-off necrosis (WON) is a significant local complication of severe pancreatitis. Despite the utilization endoscopic ultrasound-guided drainage, if necrotic debris accumulates within WON and infection remains uncontrolled, direct necrosectomy (DEN) performed using auxiliary instruments such as forceps or snares [1] [2]. Conventional techniques often involve prolonged multiple sessions because their limited ability to remove material, leading substantial patient burden. Here we present an...
Biloma is a complication of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) [1]. Despite being the first-line treatment infected bilomas, percutaneous drainage can affect daily life and pose self-extraction risks, particularly in older patients [2]. Endoscopic ultrasound (EUS)-guided offers viable alternative internal biliary drainage; however, it be challenging right liver lobe because its long distance from gastrointestinal (GI) tract [3] [4] [5]. Here,...
Post-sphincterotomy bleeding during or after endoscopic retrograde cholangiopancreatography (ERCP)-related procedures is often problematic. Although various hemostatic techniques, such as balloon compression, clipping, cautery, and covered metallic stents, are usually carried out, they time-consuming, costly, risky, difficult to perform [1]. Recently, the efficacy of a novel self-assembling peptide matrix (PuraStat; 3-D Matrix Europe SAS, France) has been reported for hemostasis in...
Endoscopic necrosectomy is an effective treatment for walled-off necrosis (WON); however, bleeding complications can be life threatening and require immediate response [1]. Blood accumulation within the WON compartment makes identifying blood vessels difficult. Furthermore, use of clips hemostasis increases risk leaving long-term remains WON. Recently, a method maintaining visibility during gastrointestinal involving injection gel with appropriate viscosity (Viscoclear; Otsuka Pharmaceutical...
Interventional endoscopic ultrasound (iEUS), including EUS-guided tissue acquisition (EUS-TA) and biliary drainage (EUS-BD), plays a crucial role in the assessment treatment of pancreaticobiliary lesions. Yet, iEUS presents challenges due to anatomical factors, posing risk serious complications. For observational EUS, studies have shown that utilizing high viscosity gel (Viscoclear; Otsuka Pharmaceutical, Tokushima, Japan) instead water fill duodenal lumen yields clearer EUS images...
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Post-endoscopic sphincterotomy (ES) bleeding is a common complication of biliary sphincterotomy. The rate post-ES varies widely and may present immediately or several days later. Endoscopic hemostasis includes injection, thermal coagulation, mechanical methods, either alone in combination. Vascular embolization surgery necessary when difficult to achieve [1].
Toyonaga and colleagues demonstrate, with accompanying video, the use of low echo reduction, which is a novel endoscopic ultrasound function provided by new processor that increases contrast without white-out. Low reduction might be useful in improving lesion boundaries needle visibility during ultrasound-guided tissue acquisition.
Among patients with malignant hilar biliary obstruction, those suffering from cholangitis sometimes require decompression of all divided branches; however, the achievement this by endoscopic retrograde cholangiopancreatography (ERCP) alone is difficult in severe such as Bismuth types III and IV [1]. In cases, combining ERCP percutaneous transhepatic drainage (PTBD) common; PTBD has been associated a decreased quality life. Endoscopic ultrasound (EUS)-guided procedures are widely performed...
Hama et al. reported a case of successful "One-step" endoscopic ultrasonography-guided hepatic cyst drainage using self-expandable metal stent (SEMS) for large cyst. placement fully covered SEMS without fistula dilation, as in this case, may be useful method the prevention leakage infected fluid into abdominal cavity.
Toyonaga and colleagues present a novel “tip-in endoscopic papillectomy” approach for resecting ampullary tumors, aiming to minimize complications like perforation residual tumor by adapting the colonic polyp mucosal resection tip-in method. The technique is described with accompanying video in case of near diverticulum. Dr Katanuma received honoraria as lecture fee from Olympus Co., Tokyo, Japan. other authors have no conflicts interest declare. Video S1 Please note: publisher not...
内視鏡的膵管ドレナージは,経乳頭・吻合部的アプローチに加え近年では経消化管的アプローチも施行されている.経乳頭・吻合部的膵管ドレナージでは,十二指腸鏡やバルーン内視鏡を用いて膵管造影およびガイドワイヤー挿入を行った後にステントあるいはチューブを留置する.経乳頭・吻合部的膵管ドレナージは慢性膵炎など症候性の膵液流出障害で積極的に施行されており,ERCP後膵炎の高リスク群における予防効果も認められている.経消化管的膵管ドレナージは,経乳頭・吻合部的膵管ドレナージ困難例に対する代替法として施行されている.超音波内視鏡下に経胃的に膵管を穿刺してガイドワイヤーを留置し,穿刺部拡張の後にステント留置あるいはランデブー法による経乳頭・吻合部的膵管ドレナージを施行する.経消化管的膵管ドレナージは確立された手技ではなく,手技成功率や偶発症率を考慮すると,現時点ではEUS関連処置に習熟した内視鏡医のみが施行すべきである.