A5084096323- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Renin-Angiotensin System Studies
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Receptor Mechanisms and Signaling
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Biliary and Gastrointestinal Fistulas
- Metabolism and Genetic Disorders
- Protein Hydrolysis and Bioactive Peptides
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pharmacogenetics and Drug Metabolism
- Radiopharmaceutical Chemistry and Applications
- Renal and Vascular Pathologies
- Neuroendocrine Tumor Research Advances
- Acute Kidney Injury Research
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Biochemical effects in animals
Tokyo Medical University
2016-2025
Nippon Steel (Japan)
2022-2024
The University of Tokyo
2023-2024
Hitachi (Japan)
2006-2024
Robotics Research (United States)
2024
Weatherford College
2023
Advanced Institute of Industrial Technology
2023
Asian Institute of Technology
2023
Tokyo Medical University Hospital
2014-2022
The Japanese Society of Gastroenterological Surgery
2022
The effects of nicardipine, classed as a calcium antagonist, on renal hemodynamics, function, and renin release were investigated in pentobarbital-anesthetized dogs. Intrarenal infusion this drug at rate 5 micrograms/min both hydrated hydropenic dogs resulted significant increase blood flow, glomerular filtration rate, urine release, with fall systemic pressure. intrarenal flow measured by the microsphere method indicated greater juxtamedullary than superficial area. During nicardipine...
Recently, a 22G Franseen needle for EUS-guided fine-needle biopsy (EUS-FNB) with three novel symmetric heels has been developed to adequately obtain core tissue.All 38 consecutive patients pancreatic masses who underwent EUS-FNB using were investigated retrospectively assess the efficacy and safety of needle. Then, outcomes histological assessments tissue obtained by EUS-FNA conventional end-cut type each 30 ductal adenocarcinoma cases compared.An accurate diagnosis was achieved mean 2...
Detection of pancreatic cancer (PC) at a resectable stage is still difficult because the lack accurate detection tests. The development biomarkers in low or non-invasive biofluids essential to enable frequent tests, which would help increase opportunity PC early stages. Polyamines have been reported as possible urine and saliva samples various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary were collected from...
Endoscopic ultrasonography-guided pancreatic duct drainage (EUS-PD) has been reported as an alternative for failed conventional endoscopic retrograde cholangiopancreatography (ERCP). However, there are few dedicated devices EUS-PD. Recently, we have developed a new plastic stent to EUS-PD and conducted feasibility study evaluate its efficacy. In the current study, evaluated long-term efficacy of this stent. Thirty patients (61 ± 14.3 years old, 14 men) with acute recurrent pancreatitis...
Halogenated nucleoside derivatives were trifluoromethylated using a solution of trifluoromethyl–copper complex, which was prepared by shaking trifluoromethyl iodide and copper powder in hexamethylphosphoric triamide filtering off the excess powder. The following nucleosides obtained moderate to good yields: 5-trifluoromethyl-uridine, -deoxyuridine, -cytidine, -deoxycytidine, -arabinosylcytosine; 8-trifluoromethyl-adenosine, -deoxyadenosine, -inosine; 6-trifluoromethylribofuranosylpurine....
Endoscopic papillectomy (EP) has been attempted not only for benign lesions but also early ampullary carcinoma (AC). However, there is still no sufficient evidence or consensus regarding the effectiveness of EP AC. Herein, we evaluated expanding indication AC.Between May 1999 and December 2016, 177 patients were diagnosed with tumor before undergoing EP, their clinical histopathological data analyzed retrospectively.There 27 Tis-T1a AC four T1b who underwent EP. Mean size was 14.1 mm 17.0...
ABSTRACT Background and Objectives: EUS-guided tissue acquisition is routinely performed for the diagnosis of gastrointestinal tract adjacent organ lesions. Recently, various types needles have been developed. However, how shape needle tip echoendoscope angle affect puncturability, has not clarified. The aim this experimental study was to compare puncturability several 22-gauge EUS-FNA fine-needle biopsy (EUS-FNB) needles, evaluate effects on puncturability. Materials Methods: following six...
A release of renin from kidney cortex slices in vitro was first reported by the present authors (1). Recently, rats, pretreated with deoxycorticosterone acetate, clipping renal artery, bleeding or decapitation, shown Jong (2) and BOZOVIC et al. (3). In their experiments, fundamental process has not been made clear. our previous paper, it pointed out that is released dog into an incubation medium depending on temperature pH about 10% contained original within 60 minutes incubation. Presently,...
Tract dilation prior to stent placement is an important step in endoscopic ultrasound-guided hepaticogastrostomy. Mukai and colleagues describe their use of a novel catheter with longer balloon, which enables one-step tract the gastric wall, liver parenchyma, bile duct shortening procedure reducing leakage.
Endoscopic intraductal radiofrequency ablation (ID‐RFA) can curatively treat residual lesions after endoscopic papillectomy. This study aimed to verify the tissue invasiveness of ID‐RFA using a novel RF generator and explore its appropriate settings in an animal experiment, followed by small clinical study. Pig liver specimens were ablated dedicated catheter two generators investigate structural differences between them effects produced under various voltage power settings. Appropriate for...
Stent migration occurs in endoscopic retrograde cholangiopancreatography (ERCP)-related procedures with a frequency of 5%–10%,1 but gastrointestinal or transmural perforation is rare.2 Here, we report case duodenal caused by dislodged pigtail plastic stent benign biliary stricture. A 73-year-old man was referred for examination Cholangiography showed short-segment stricture the lower bile duct (Figure 1a). Biopsy specimens were collected and 7 Fr × cm placed through 1b). The biopsy no...
Endoscopic retrograde cholangiography (ERC) has been reported to be useful in the treatment of bile leaks.1 However, when duct branches from site a leak are narrow, it is often difficult identify location leak. Holograms, which computer-generated graphics models, have recently used with mixed reality (MR) techniques as surgical navigation tool.2 We previously case using MR technology project three-dimensional (3D) hologram image ducts space during interventional endoscopic ultrasound (EUS).3...
Abstract The use of low-compressive-strength concrete hollow blocks (CHB) as construction material in developing countries presents significant challenges to earthquake resilience. Weak CHBs are inherently vulnerable earthquakes, not just at the structural level (in-plane, out-of-plane wall collapses, and roof failures), but also individual masonry unit level. This vulnerability increases risk failures during posing a threat safety building occupants. study investigates effectiveness...
An intradiverticular papilla can make biliary cannulation challenging during endoscopic retrograde cholangiopancreatography (ERCP). Some techniques to overcome this issue have been reported, such as the two-devices-in-one-channel method,1 pancreatic guidewire technique,2 precutting technique,3 and rendezvous technique.4 The recently developed traction device5 rotatable sphincterotome might be useful for of an papilla. Here, we report a case successful using device (Figures 1 2). 84-year-old...
Background: Early detection of pancreatic cancer using existing tumor markers is challenging, and novel biomarkers are needed. Apolipoprotein A2 (APOA2), which not directly produced by tumors, may help detect through mechanisms distinct from carbohydrate antigen 19-9 (CA 19-9). This study aimed to evaluate the diagnostic performance APOA2-isoform (APOA2-i) Index in patients with cancer. Methods: Serum levels APOA2-i CA were measured 76 (Stage 0, n = 5; I, 4; II, 15; III, 19; IV, 33) 98...
Abstract Purpose We evaluated the diagnostic and therapeutic capabilities of endoscopic ultrasonography (EUS) in pancreaticobiliary diseases. aimed to validate efficiency detective flow imaging (DFI), shear wave elastography (SWE), other advanced techniques. Methods used new EUS scopes (EG‐740 UT G‐580UR) latest ultrasound equipment (ARIETTA 850) (Fujifilm Healthcare, Kanagawa, Japan). Diagnostic procedures were performed 16 cases, including pancreatic cancer intraductal papillary mucinous...