A5042948477- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal vascular conditions and treatments
- Cancer therapeutics and mechanisms
- Neuroblastoma Research and Treatments
- Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Vascular Malformations and Hemangiomas
- Dermatological and COVID-19 studies
- Radiomics and Machine Learning in Medical Imaging
Sapporo Medical University
2014-2024
Teine Keijinkai Hospital
2023-2024
Sapporo Science Center
2019
Sapporo University
2018
Immunotherapy using anti-programmed death 1 ligand (PD-L1) antibodies has shown clinical efficacy against hepatocellular carcinoma (HCC) and is recognized as the first-line treatment for unresectable HCC. PD-L1 expression affected by various cytokines produced immune cells in tumor microenvironment; however, there limited information about effects of cytokine interactions on expression. In this study, we examined how induce HCC cells. Both interferon gamma (IFN-γ) interleukin beta (IL-1β)...
Pancreatic cancer is one of the cancers with very poor prognosis; there an urgent need to identify novel biomarkers improve its clinical outcomes. Circulating tumor DNA (ctDNA) from liquid biopsy has arisen as a promising biomarker for detection and surveillance. However, it known that ctDNA rate in resected pancreatic low compared other types cancer. In this study, we collected paired plasma samples 145 patients. Plasma were 71 patients treatment-naïve status 74 after neoadjuvant therapy...
Pancreatic cancer is a highly aggressive malignancy, with <50% patients surviving beyond 6 months after the diagnosis, and thus, there an urgent need to explore new diagnostic therapeutic approaches for this disease. Therefore, we conducted microRNA (miRNA) array analysis detect miRNA molecules potentially associated pancreatic malignancy. To assess identified miRNAs, performed quantitative reverse transcription-PCR on 248 ductal adenocarcinomas (UICC stage II). We also examined expression...
Purpose Since December 2019, coronavirus disease 2019 (COVID-19) has spread rapidly across the world. During pandemic, physicians in our hospital have had to respond both issue of treating patients and increasing domestic burden associated with social disruption. The purpose this study was assess how much on doctors, especially female increasing. Material methods Physicians’ Career Support Committee Sapporo Medical University conducted a questionnaire survey. inquired about wide range...
Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed clarify the clinical outcomes of biliary drainage a metal stent (MS) or plastic (PS) during NAC/NACRT. Between October 2013 and April 2016, 96 were registered for Of these, 29 who underwent MS PS before NAC/NACRT subsequent pancreatoduodenectomy retrospectively analyzed regard patient characteristics, preoperative recurrent obstruction rate,...
Effective multidisciplinary approaches for unresectable pancreatic cancer (UR-PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes patients clinically diagnosed with UR-PC, focusing on the efficacy CS.Patients ineligible two multicenter phase II studies conducted by Hokkaido Pancreatic Cancer Study Group (HOPS) were recruited. Sequential treatment regimens, radical surgery, overall...
Bile duct cancer is a highly aggressive malignancy wherein early diagnosis difficult and few treatment options are available. MicroRNA-31 (miR-31) reported to be related with survival in patients gastrointestinal cancers; however, the regulatory mechanism of miR-31 association between expression bile cases have not been established. Thus, we evaluated tissues assessed its relationship prognosis. Additionally, examined effects several cytokines on expression. The study included 81 samples...
Abstract Rationale: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized by high levels of serum IgG4, swollen organs with fibrosis and abundant infiltration IgG4-positive plasmacytes. Patient Concerns: An 82-year-old male visited our hospital for an evaluation pancreatic enlargement bilateral submandibular adenopathy. Further investigation revealed elevation IgG4 lacrimal We diagnosed him IgG4-related started administration corticosteroid (CS)...
Walled-off necrosis (WON) is a significant local complication of severe pancreatitis. Despite the utilization endoscopic ultrasound-guided drainage, if necrotic debris accumulates within WON and infection remains uncontrolled, direct necrosectomy (DEN) performed using auxiliary instruments such as forceps or snares [1] [2]. Conventional techniques often involve prolonged multiple sessions because their limited ability to remove material, leading substantial patient burden. Here we present an...
Mutation in K-RAS (K-RAS-MT) plays important roles both cancer progression and resistance to anti-epidermal growth factor receptor (EGFR) therapy gastrointestinal tumors. Insulin-like factor-1 (IGF-1R) signaling is required for carcinogenicity of many tumors as well. We have previously shown successful cell lines bearing a mutation using an anti-IGF-1R monoclonal antibody. In this study, we sought evaluate effects forced K-RAS-MT expression on representing possible second mechanism anti-EGFR...
Abstract Background UGT1A1 *28 and *6 polymorphism is associated with reduced enzyme activity severe toxicities of irinotecan, especially in patients homozygous or heterozygous for UGT1A1*28 both (double-variant-type polymorphism, UGT1A1-DV). FOLFIRINOX one the standard treatments metastatic pancreatic cancer (PC). The optimal dose irinotecan as a component has not been established yet UGT1A1-DV. Patients methods Advanced PC UGT1A1-DV who had received at least cycle from December 2013 to...
Endoscopic ultrasonography (EUS), with its high spatial resolution, is indispensable for diagnosing the nature and invasiveness of gallbladder lesions [1] [2] [3]. The bile ducts are hollow organs that do not originally have internal echo sources susceptible to multiple reflections other artifacts. Recently, a new endoscopic ultrasound (EUS) processor (EVIS EUS EU-ME3; Olympus, Tokyo, Japan) was launched equipped novel anti-artifact function called low reduction (LER). LER suppresses areas...
Abstract Arteriovenous malformation (AVM) is defined as a disease that causes blood flow abnormality due to anastomoses of the arteries and veins. AVM can occur in any gastrointestinal tract, but pancreatic (P‐AVM) very rare. Previous reports demonstrated contrast‐enhanced CT (CECT) typically showed abnormal vascular network pancreas. We present 58‐year old man with history acute pancreatitis. He was referred our hospital for examination mass. CECT round‐shaped hypervascular lesion diameter...
650 Background: In patients with collagen disease, such as rheumatoid arthritis, steroids and immunomodulators are often used for treatment. These treatments increase the risk of adverse events, including infections; thus, cancer disease excluded from clinical trials chemotherapy cancer. Therefore, evidence is lacking regarding safety efficacy pancreatic concomitant diseases. Methods: This was a multicenter, retrospective study in Japan. Patients who started first-line or chemoradiotherapy...
In patients with altered anatomy, biliary strictures are widely overcome using balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP). As the enteroscope has a small-diameter channel and scope maneuverability is poor, severe often difficult to overcome. such cases, dilation previously been achieved screw-type stent retrievers [1] [2]. Recently, however, novel drill dilator (Tornus ES; Asahi Intecc Co., Ltd., Aichi, Japan) developed specifically for penetrating...
Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PD) is performed as an alternative when conventional endoscopic has failed [1]. Although accurately puncturing a narrow remains challenging, contrast-enhanced EUS been reported to be effective in poorly visible ducts [2] [3]. Low echo reduction (LER) mode, which incorporated into new processor (EVIS EU-ME3; Olympus, Tokyo, Japan), enhances visibility by suppressing low signals while maintaining high areas [4] [5]; this method may...