A5060821852- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Full-Duplex Wireless Communications
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Energy Harvesting in Wireless Networks
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Plant Virus Research Studies
- Viral Infections and Immunology Research
- COVID-19 diagnosis using AI
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Antenna Design and Analysis
- Herpesvirus Infections and Treatments
- Social Issues and Policies in Latin America
- Problem and Project Based Learning
- COVID-19 Impact on Reproduction
- Hematological disorders and diagnostics
- Ultrasound in Clinical Applications
- Pneumonia and Respiratory Infections
United States Army Medical Command
2025
Joint Base San Antonio
2025
Inserm
2015-2024
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2018-2024
Hôpitaux Universitaires de Strasbourg
2015-2024
Université de Strasbourg
2015-2024
Immuno-Rhumathologie moléculaire
2019-2024
Institut de Virologie
2021-2022
Bipar
2019
There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients nontransplant patients. We enrolled two groups patients hospitalized for COVID-19, that is, kidney (KTR) from French Registry Solid Organ Transplant (n = 306) a single-center cohort 795). An analysis was performed among subgroups matched age factors or mortality. Severe defined as admission (or transfer) to an intensive care unit, need mechanical ventilation, death. were...
BackgroundAssessment of the kinetics SARS-CoV-2 antibodies is essential in predicting risk reinfection and durability vaccine protection.MethodsThis a prospective, monocentric, longitudinal, cohort clinical study. Healthcare workers (HCW) from Strasbourg University Hospital were enrolled between April 6th May 7th, 2020 followed up to 422 days. Serial serum samples tested for against Receptor Binding Domain (RBD) spike protein nucleocapsid (N) characterize incidence reinfection....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing disease 2019 (COVID-19) and significant mortality. However, data on viral loads antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal plasma via reverse transcription-polymerase chain reaction SARS-CoV-2 serology enzyme-linked immunosorbent assay study their association with severe forms of COVID-19 death kidney transplant recipients. In this study, we...
BK virus–associated nephropathy (BKVAN) causes renal allograft dysfunction. The current management of BKVAN relies on pre-emptive adaptation immunosuppression according to viral load monitoring. However, this empiric strategy is not always successful. Therefore, pretransplant predictive markers are needed. In a prospective longitudinal study, we enrolled 168 kidney transplant recipients and 69 matched donors. To assess the value BKV genotype–specific neutralizing antibody (NAb) titers as...
Abstract Background Neurological manifestations are common in patients with coronavirus disease 2019 (COVID-19), but little is known about pathophysiological mechanisms. In this single-center study, we examined neurological 58 patients, including cerebrospinal fluid (CSF) analysis and neuroimaging findings. Methods The study included COVID-19 whom severe acute respiratory syndrome 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction screening on CSF were performed. Clinical,...
Abstract Introduction The ongoing COVID‐19 pandemic has led to devastating repercussions on health care systems worldwide. This viral infection a broad clinical spectrum (ranging from influenza‐like disease, pneumonia, and hypoxemia acute respiratory distress syndrome requiring prolonged intensive unit stays). prognostic impact of measuring load nasopharyngeal swab specimens (by reverse transcriptase polymerase chain reaction [RT‐PCR]) is yet be elucidated. Methods Between March 3 April 5,...
BK virus (BKV) replication occurs frequently in kidney transplant recipients (KTR), potentially leading to BKV-associated nephropathy (BKVAN) and graft loss. Patients with high titers of BKV-neutralizing antibodies (NAbs) are protected against BKV replication, intravenous immunoglobulin (IVIg) infusion can increase NAb titers. We investigated whether early IVIg administration prevents patients low (<4 log10 the BKV-specific genotype). Based on day transplantation, KTR followed Strasbourg...
Abstract Assessment of the kinetics SARS-CoV-2 antibodies is essential in predicting protection against reinfection and durability vaccine protection. Here, we longitudinally measured Spike (S) Nucleocapsid (N)-specific 1,309 healthcare workers (HCWs), including 916 COVID-19 negative HCWs 393 convalescent for up to 422 days post-symptom. From month (M)1 M7-9 post-infection, decreased moderately a biphasic model, with men showing slower decay anti-N (p=0.02), faster anti-S (p=0.0008) than...
Cases of flea-borne spotted fever (FBSF) have been on a steady increase in the southern United States and produce highest numbers reported vector-borne disease cases Texas. Historically, were largely murine typhus caused by Rickettsia typhi characterized exposure to rodent fleas. However, more recently, rickettsiosis R. felis cat flea, Ctenocephalides felis, may be dominant disease. We describe management child with complex clinical picture, including sickle cell β-thalassemia, bullous...
International guidelines define a BK virus (BKV) load of ≥4 log10 copies/ml as presumptive BKV-associated nephropathy (BKVN) and cutoff for therapeutic intervention. To investigate whether BKV DNA loads (BKVL) are comparable between laboratories, 2 panels 15 8 clinical specimens (urine, whole blood, plasma) harboring different genotypes were distributed to 20 27 French hospital centers in 2013 2014, respectively. Although 68% the reported results fell within acceptable range expected result...
A 56-year-old man presented a particularly severe and multisystemic case of coronavirus disease 2019 (COVID-19). In addition to the common lung quite pulmonary embolism kidney injuries, he ocular intestinal injuries that, our knowledge, have not been described in COVID-19 patients. Although it is difficult make pathophysiological hypotheses about single case, multiplicity injured organs argues for systemic response infection. better understanding physiopathology should feed discussion...
Introduction Certain trace elements are essential for life and affect immune system function, their intake varies by region population. Alterations in serum Se, Zn Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs correlates risk different countries Europe. Methods Serum samples from 551 patients (including 87 non-survivors) who had participated observational studies Europe (Belgium, France, Germany, Ireland, Italy, Poland)...
Abstract Transplant recipients display poor responses to SARS‐CoV‐2 mRNA vaccines. In this retrospective study, we investigate torque teno virus (TTV) viral load (VL), a ubiquitous reflecting global immune response levels, as predictive factor of vaccine in kidney transplant (KTR). Four hundred and fifty‐nine KTR having received two doses were enrolled, 241 them subsequently third dose. Antireceptor‐binding domain (RBD) IgG was assessed after each dose TTV VL measured pre‐vaccine samples....
BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is one of the major causes kidney graft dysfunction, and there are no BKPyV-specific antiviral therapies available. BKPyV neutralizing antibodies (NAbs) play key roles in protecting against replication represent a potential therapeutic or preventive strategy. In this study, we evaluated NAb titers intravenous immunoglobulin (i.v. Ig) preparations transplant recipients (KTR) before after i.v.
Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications immunocompromised patients. Here, we describe the vivo variability and evolution of polyomavirus by deep sequencing. Our data reveal highest genomic evolutionary rate described viruses, i.e., 10−3–10−5 substitutions per nucleotide site year. High mutation rates viruses allow their escape from immune surveillance adaptation to new hosts. By combining mutational landscapes...