A5057739260- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Gene expression and cancer classification
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Retinoids in leukemia and cellular processes
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- French Urban and Social Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Video Surveillance and Tracking Methods
- Genomics and Chromatin Dynamics
- Gene Regulatory Network Analysis
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Alzheimer's disease research and treatments
- Advanced Neural Network Applications
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Protein Structure and Dynamics
Institute for Research in Immunology and Cancer
2015-2024
Université de Montréal
2014-2024
Open Data Institute
2017
University of Oxford
2017
Vanier College
2013
Centre Hospitalier de l’Université de Montréal
2008-2010
University of Tennessee Health Science Center
2009
Hôpital Saint-Luc
2008
Regroupement Québécois sur les Matériaux de Pointe
2005
University of Ottawa
1969
Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development novel incurable diseases such as HIV cancer. In this study, we have used functional genomics polychromatic flow cytometry define signature immune response yellow fever (YF) vaccine 17D (YF17D) in a cohort 40 volunteers followed for up 1 yr after vaccination. We show that immunization with YF17D leads an integrated includes several effector arms innate immunity, including...
In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion enhancer zeste homolog 2 ( Ezh2 ). Tumor cells little residual H3K27 trimethylation marks compared controls. EZH2 is a component PRC2 Polycomb group protein complex, which associated DNA methyltransferases. Using next-generation sequencing, identify alteration gene expression levels and acquired mutations PRC2-associated genes DNMT3A JARID2 ) human adult T-ALL....
Eradication of HIV-1 with highly active antiretroviral therapy (HAART) is not possible due to the persistence long-lived, latently infected resting memory CD4 + T cells. We now show that latency can be established in cells after exposure ligands for CCR7 (CCL19), CXCR3 (CXCL9 and CXCL10), CCR6 (CCL20) but unactivated The mechanism did involve cell activation or significant changes gene expression, was associated rapid dephosphorylation cofilin filamentous actin. Incubation chemokine before...
Counting objects in digital images is a process that should be replaced by machines. This tedious task time consuming and prone to errors due fatigue of human annotators. The goal have system takes as input an image returns count the inside justification for prediction form object localization. We repose problem, originally posed Lempitsky Zisserman, instead predict map which contains redundant counts based on receptive field smaller regression network. network predicts exist this frame. By...
Constitutive overexpression of the Mdr1 efflux pump is an important mechanism acquired drug resistance in yeast Candida albicans. The zinc cluster transcription factor Mrr1 a central regulator MDR1 expression, but other factors have also been implicated regulation. To better understand how MDR1-mediated achieved this fungal pathogen, we studied interdependence and two regulators, Upc2 Cap1, control expression. A mutated, constitutively active could upregulate confer absence or Cap1. On hand,...
For decades, the global impact of genomic polymorphisms on repertoire peptides presented by major histocompatibility complex (MHC) has remained a matter speculation. Here we present novel approach that enables high-throughput discovery polymorphic MHC class I-associated (MIPs), which play role in allorecognition. On basis comprehensive analyses landscape MIPs eluted from B lymphoblasts two MHC-identical siblings, show 0.5% non-synonymous single nucleotide variations are represented MIP...
ABSTRACT Cap1p, a transcription factor of the basic region leucine zipper family, regulates oxidative stress response (OSR) in Candida albicans . Alteration its C-terminal cysteine-rich domain (CRD) results Cap1p nuclear retention and transcriptional activation. To better understand function C. , we used genome-wide location profiling (chromatin immunoprecipitation-on-chip) to identify targets vivo. A triple-hemagglutinin (HA 3 ) epitope was introduced at C terminus wild-type (Cap1p-HA or...
Abstract Based on transcriptomic analyses of thousands samples from The Cancer Genome Atlas, we report that expression constitutive proteasome (CP) genes ( PSMB5, PSMB6, PSMB7 ) and immunoproteasome (IP) PSMB8, PSMB9, PSMB10 is increased in most cancer types. In breast cancer, IP was determined by the abundance tumor infiltrating lymphocytes high associated with longer survival. contrast, upregulation acute myeloid leukemia (AML) a cell-intrinsic feature not Expression AML IFN-independent,...
Immunotherapy remains underexploited in acute myeloid leukemia (AML) compared to other hematological malignancies. Currently, gemtuzumab ozogamicin is the only therapeutic antibody approved for this disease. Here, identify potential targets immunotherapeutic intervention, we analyze surface proteome of 100 genetically diverse primary human AML specimens identification cell proteins and conduct single-cell transcriptome analyses on a subset these assess antigen expression at sub-population...
To identify novel biomarkers for HIV-1 resistance, including pathways that may be critical in anti-HIV-1 vaccine design, we carried out a gene expression analysis on blood samples obtained from highly exposed seronegatives (HESN) commercial sex worker cohort Nairobi and compared their profiles to negative controls. Whole were collected 43 resistant workers similar number of Total RNA was extracted hybridized the Affymetrix HUG 133 Plus 2.0 micro arrays (Affymetrix, Santa Clara CA). Output...
Purpose:RUNX1-mutated (RUNX1mut) acute myeloid leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a better genetic characterization of this AML subgroup and design efficient therapeutic strategies disease. Toward goal, we further dissected mutational spectrum gene expression profile RUNX1mut correlated these results to drug sensitivity identify novel compounds targeting subgroup.Experimental Design: RNA-sequencing 47 primary specimens was performed sequencing...
There is experimental evidence suggesting that the toxicity of neurodegenerative diseases such as Alzheimer’s disease may result from soluble intermediate oligomers. It therefore important to characterize extensively early steps oligomer formation at atomic level. As these structures are metastable and short lived, data difficult obtain they must be complemented with numerical simulations. In this work, we use activation-relaxation technique coupled a coarse-grained energy model study in...