A5051250373- Immune cells in cancer
- Immune Response and Inflammation
- Immune responses and vaccinations
- interferon and immune responses
- Immune Cell Function and Interaction
- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Respiratory Health Research
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cytokine Signaling Pathways and Interactions
- Eicosanoids and Hypertension Pharmacology
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Pediatric health and respiratory diseases
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Peroxisome Proliferator-Activated Receptors
- Fungal Infections and Studies
- Genomics and Phylogenetic Studies
McGill University Health Centre
2015-2025
McGill University
2016-2024
Université du Québec à Trois-Rivières
2023-2024
Christie (Canada)
2015-2022
Institut Universitaire Européen de la Mer
2020
Université de Bretagne Sud
2020
Inserm
2014-2015
Institut Pasteur
2014-2015
Sorbonne Université
2014-2015
A greater understanding of hematopoietic stem cell (HSC) regulation is required for dissecting protective versus detrimental immunity to pathogens that cause chronic infections such as Mycobacterium tuberculosis (Mtb). We have shown systemic administration Bacille Calmette-Guérin (BCG) or β-glucan reprograms HSCs in the bone marrow (BM) via a type II interferon (IFN-II) interleukin-1 (IL1) response, respectively, which confers trained against Mtb. Here, we demonstrate that, unlike BCG...
Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch our immune system. There is ample evidence vaccines such as bacillus Calmette-Guérin (BCG) induce protective responses (trained immunity) against heterologous pathogens. Here we show while BCG vaccination significantly reduces morbidity and mortality influenza A virus (IAV), fails provide...
Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient 12-lipoxygenase and 15-lipoxygenase (Alox15-/- mice) neonatal neutrophil-derived 12-HETE is required for self-renewal maintenance of alveolar (AMs) during lung development. Although seeding differentiation AM progenitors remained intact, absence led to a significant reduction AMs adult lungs...
The lung naturally resists Aspergillus fumigatus ( Af ) in healthy individuals, but multiple conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of natural resistance and its breakdown are undefined. We investigated three distinct predisposing aspergillosis—severe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection, influenza A viral pneumonia, systemic corticosteroid use—in human patients murine models. found a conserved essential...
Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar (AM) and bone marrow-derived (BMDM). Here, we show that after infection with a virulent strain of Mycobacterium tuberculosis (H37Rv), primary murine AM exhibit unique transcriptomic signature characterized by metabolic reprogramming from conventional BMDM. In contrast to BMDM, failed shift oxidative phosphorylation (OXPHOS) glycolysis consequently were unable control an avirulent (H37Ra)....
The type I interferon pathway plays a critical role in both host defense and tolerance against viral infection thus requires refined regulatory mechanisms. RIPK3-mediated necroptosis has been shown to be involved anti-viral immunity. However, the exact of RIPK3 immunity Influenza A Virus (IAV) is poorly understood. In line with others, we, herein, show that Ripk3-/- mice are highly susceptible IAV infection, exhibiting elevated pulmonary load heightened morbidity mortality. Unexpectedly,...
Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike resistance, the mechanisms underlying disease remain poorly understood. In present study, we investigated whether adjuvant (β-glucan) can reprogram innate immunity to provide protection against influenza A virus (IAV) infection. β-Glucan treatment reduces morbidity mortality IAV infection, independent of resistance. The enhanced...
Abstract Staphylococcus aureus is a common cause of bacterial infections in respiratory diseases. It secretes molecules to dampen host immunity, and the recently identified adenosine one these molecules. The type IIA secretory phospholipase A2 (sPLA2-IIA) protein endowed with antibacterial properties, especially against Gram-positive bacteria such as S. aureus. However, role sPLA2-IIA–mediated killing by still unknown. present studies showed that mutant lacking production (∆adsA strain)...
Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations response to influenza infection and their impact on disease severity remain unclear. Here, we describe, a preclinical model of mid-gestation pregnancy, mechanism enhanced host defense against A virus (IAV) localized the nasal cavity that limits viral replication reduces magnitude intrapulmonary responses. Consequently, pregnant mice show reduced pulmonary pathology preserved...
Abstract Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self‐antigens with damage to multiple organs. Immunization SLE autoantigen β 2 ‐glycoprotein I (β GPI) and lipopolysaccharide (LPS), a known trigger necroptosis, induces murine model SLE. We hypothesized that necroptotic cells, like apoptotic provide “scaffold” cellular self‐antigens, but, unlike cells do so in proinflammatory immunogenic context. demonstrate GPI indeed binds...
Biofilms produced by Pseudomonas aeruginosa present a serious threat to cystic fibrosis patients. Here, we report the draft genome sequences of four isolates displaying various mucoid and biofilm phenotypes. The estimated average size was about 6,255,986 ± 50,202 bp with mean G+C content 66.52 0.06%.