A5027131774- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Autoimmune and Inflammatory Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Criminal Law and Evidence
- Cardiac Valve Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Whipple's Disease and Interleukins
- Crime and Detective Fiction Studies
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Shakespeare, Adaptation, and Literary Criticism
- Genital Health and Disease
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Connective tissue disorders research
- Viral Infections and Immunology Research
University of Calgary
2011-2022
University of Glasgow
2021
Calgary Laboratory Services
2012-2019
University of Edinburgh
2018
Health Sciences Centre
2012
University of British Columbia
2012
Foothills Medical Centre
2011
Abstract Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects dexamethasone severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, bacterial was associated with expansion distinct neutrophil...
The lung naturally resists Aspergillus fumigatus ( Af ) in healthy individuals, but multiple conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of natural resistance and its breakdown are undefined. We investigated three distinct predisposing aspergillosis—severe SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection, influenza A viral pneumonia, systemic corticosteroid use—in human patients murine models. found a conserved essential...
This study correlates low strain tangential modulus (LTM) and transition zone onset (TZo) stress, biomechanical parameters that occur within the physiological range of stress seen in vivo, with tissue strength histopathologic changes aneurysmal ascending aortic tissue.Ascending aneurysm samples were collected from 41 patients undergoing elective resection. Samples subjected to planar biaxial testing quantify LTM TZo. These then correlated assessed uniaxial quantification pathologic...
We describe the architectural patterns of advanced ovarian/pelvic high-grade serous carcinomas that have been treated with upfront surgery, followed by adjuvant chemotherapy or neoadjuvant chemotherapy, interval debulking to explore association chemotherapeutic response. For 70 cases (i.e. stage III/IV) (33 platinum resistant/intermediate, 37 sensitive; 24 neoadjuvantly treated, 44 primary surgery), all tumor-containing histologic slides were reviewed 1 3 pathologists. Histologic type was...
► NUT midline carcinoma is a rare and aggressive cancer arising in structures of squamous cell lineage. Diagnosis by use molecular tests possible with clinical suspicion. refractory to conventional treatments, but understanding alterations may lead an effective therapy.
The current clinical guidelines for the management of aortic abdominal aneurysms (AAAs) overlook structural and mechanical heterogeneity tissue its role in regional weakening that drives disease progression. This study is a comprehensive investigation biomechanical AAA along length circumference aorta, by means ex vivo properties. Biaxial testing histological analysis were performed on human specimens systematically collected during open repair surgery. Wall-shear stress three-dimensional...
Background: Current clinical practice for the assessment of abdominal aortic aneurysms (AAA) is based on vessel diameter and does not account multifactorial, heterogeneous remodeling that results in regional weakening wall leading to growth rupture. The present study was conducted determine correlations between a novel non-invasive surrogate measure from invasive analyses performed corresponding ex vivo samples. Tissue samples were evaluated classify local likelihood further degeneration...
Fibromuscular dysplasia is a rare, non-atherosclerotic non-inflammatory vascular disease that most commonly involves the renal arteries and carotid arteries, but has been described in nearly every bed body. Complications of fibromuscular include aneurysms dissection. We present rare case involving aorta, complicated by type A aortic
Reliable animal models are an important aspect of translational research, especially for relatively uncommon clinical entities such as fusiform aneurysms. While several exist, very few tailored to cerebral aneurysms, which have unique attributes compared abdominal The authors aimed build from previous create a aneurysm model that is simple use and reliable.
Several studies have demonstrated a potential interaction between mesenchymal stem cells (MSCs) and saccular aneurysms. In this study, we sought to determine whether allogenic bone marrow-derived MSCs had the ability prevent aneurysm formation in known rabbit elastase model. were injected intravenously experimental rabbits at time of surgical creation two weeks postcreation compared with control receiving vehicle injection. Angiography was used compare measurements four postcreation,...
A 69-year-old female with antisynthetase syndrome, a history of multiple recurrent infections, and documented previous negative titres for anti-neutrophil cystoplasmic antibody (ANCA) suddenly developed de novo MPO-ANCA-associated glomerulonephritis three weeks after fecal microbiota transplantation (FMT) Clostridium difficile infections. Six months following her FMT less than two treatment urosepsis, she severe cholestasis, markedly elevated ferritin hypertriglyceridemia. An initial liver...
Solid organ transplant recipients are vulnerable to severe infection during induction therapy. We report a case of 67-year-old male who died unexpectedly 10 days after receiving kidney on February 10, 2020. There was no clear cause death, but COVID-19 considered retrospectively, as the death occurred shortly first confirmed in Canada. presence SARS-CoV-2 components renal allograft and native lung tissue using immunohistochemistry for spike protein RNA scope situ hybridization RNA. Results...
Summary SARS-CoV-2 is a novel coronavirus that causes acute respiratory distress syndrome (ARDS), death and long-term sequelae. Innate immune cells are critical for host defense but also the primary drivers of ARDS. The relationships between innate cellular responses in ARDS resulting from COVID-19 compared to other ARDS, such as bacterial sepsis unclear. Moreover, beneficial effects dexamethasone therapy during severe remain speculative, understanding mechanistic could improve...
BackgroundMyocarditis is generally a self-limited illness with benign course. Certain pathogens—such as cytomegalovirus (CMV)—can cause severe/fulminant forms of myocarditis leading to congestive heart failure or sudden cardiac death (SCD). Case PresentationA 54-year-old female was diagnosed systemic lupus erythematosus (SLE) in hospital and received inpatient immunosuppression due significant multi-organ involvement. After prolonged admission, she later died an in-hospital arrest. Autopsy...