A5091761697- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Aortic aneurysm repair treatments
- Mechanical Circulatory Support Devices
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Pericarditis and Cardiac Tamponade
- Cardiac Arrest and Resuscitation
- Peptidase Inhibition and Analysis
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Lipoproteins and Cardiovascular Health
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
Libin Cardiovascular Institute of Alberta
2017-2025
University of Calgary
2017-2024
University of Alberta
2024
Calgary Laboratory Services
2020-2024
Foothills Medical Centre
2019-2024
Spinal Cord Injury BC
2022
GTx (United States)
2021
Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on impact of blood-derived monocytes repair. Here we examined contribution resident cavity macrophages located pericardial space adjacent site injury. We found that disruption accelerated maladaptive post-MI remodeling. Gata6+ mouse fluid contributed reparative immune response. Following experimental MI, these invaded...
Cardiac fibrosis is a significant contributor to heart failure, condition that continues affect growing number of patients worldwide. Various cardiovascular comorbidities can exacerbate cardiac fibrosis. While fibroblasts are believed be the primary cell type underlying fibrosis, recent and emerging data suggest other types also potentiate or expedite fibrotic processes. Over past few decades, clinicians have developed therapeutics blunt development progression these strategies yielded...
Abstract Coronary heart disease is a leading cause of death. Tissue remodeling and fibrosis results in cardiac pump dysfunction ischemic failure. Cardiac fibroblasts may rebuild damaged tissues when prompted by suitable environmental cues. Here, we use acellular biologic extracellular matrix scaffolds (bioscaffolds) to stimulate pathways muscle repair restore tissue function. We show that bioscaffolds with bioinductive properties can redirect microvascular networks avoid fibrosis....
Background: To analyze long-term outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR). Methods: All consecutive 97 TEVAR between September 2014 and 2022 were included the study. The primary outcome was incidence of overall death major adverse cardiovascular cerebrovascular events (MACCE). Results: Mean age 70.4 years, 22 (23.2%) had disease (CBVD). 49 (51.6%) prior cardiac surgery intervention 8 (8.5%) valve replacement. Twenty-eight (28.8%) presented with dissection,...
The management of hypertrophic cardiomyopathy (HCM) has evolved in recent years. Surgery continues to play an important role the patients with HCM. This is particularly relevant for selected who prefer minimize their reliance on medications symptom control or remain symptomatic despite receiving optimal maximal guideline-directed medical therapy. Herein, we provide a succinct primer latest literature pertaining surgical
There is a paucity of data on the inflammatory response that takes place in pericardial space after cardiac surgery. This study provides comprehensive assessment local postoperative response.Forty-three patients underwent cardiotomy, where native fluid was aspirated and compared with effluent collected at 4, 24, 48 hours' postcardiopulmonary bypass. Flow cytometry used to define levels proportions specific immune cells. Samples were also probed for concentrations cytokines, matrix...
ObjectivesCardiac surgery using cardiopulmonary bypass contributes to a robust systemic inflammatory process. Local intrapericardial postsurgical inflammation is believed trigger important clinical implications, such as postoperative atrial fibrillation and intrathoracic adhesions. Immune mediators in the pericardial space may underlie complications.MethodsIn this prospective pilot study, 12 patients undergoing isolated coronary artery graft were enrolled. Native fluid venous blood samples...
Abstract Bicuspid aortic valve (BAV) disease has significant gaps in its clinical management practices. To highlight the potential utility of advanced hemodynamic biomarkers strengthening BAV assessment, we used 4-dimentional flow magnetic resonance imaging to investigate altered hemodynamics ascending aorta (AAo). A total 32 healthy controls and 53 age-matched patients underwent cardiac at 3T, with cine 4D-flow. Analysis planes were placed along 3D-segmented aortas left ventricular outflow...