A5024166075- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Neuroscience and Neural Engineering
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- ECG Monitoring and Analysis
- Infectious Aortic and Vascular Conditions
- Cardiac Imaging and Diagnostics
- Pluripotent Stem Cells Research
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Connexins and lens biology
Lankenau Institute for Medical Research
2018-2025
Main Line Health
2021-2025
Lankenau Medical Center
2018-2024
Lankenau Heart Institute
2021-2024
Thomas Jefferson University Hospital
2022
Masonic Medical Research Laboratory
2007-2018
Gilead Sciences (United States)
2009-2012
Gilead Sciences (Spain)
2009
Weatherford College
2008
Hospital Ramos Mejía
1997-2007
Recent studies have shown that canine ventricular epicardium and endocardium differ with respect to electrophysiological characteristics pharmacological responsiveness these differences are in large part due the presence of a prominent transient outward current Ito spike-and-dome morphology action potential but not endocardium. In attempting quantitate assess their gradation across wall, we encountered subpopulation cells deep subepicardial layers different from those either or These cells,...
Amiodarone Reduces Transmural Dispersion. Introduction: is a potent antiarrhythmic agent used in the management of both atrial and ventricular arrhythmias. In addition to its β‐blocking properties, amiodarone known lo block sodium, potassium, calcium channels heart. Its complex electropharmacology notwithstanding, reasons for high efficacy drug remain unclear. Also not well understood basis low incidence proarrhythmia seen with relative other agents Class III actions. The present study was...
Distribution of M Cells. Introduction: cells and transitional residing in the deep structures ventricular free walls are distinguished by ability their action potentials to prolong disproportionately those other at relatively slow rates. This feature cell due, least part, a smaller contribution slowly activating component delayed rectifier current (I ks ) is thought contribute unique pharmacologic responsiveness cells, making them primary targets myocardium lor agents that cause potential...
M Cells in the Guinea Pig. Introduction : Recent studies have described presence of cells deep layers canine and human ventricle displaying electrophysiologic pharmacologic features different from those epicardial (EPI) endocardial (ENDO) cells. The cell is distinguished electrophysiologically by ability its action potential to prolong disproportionately that other myocardial with slowing stimulation rate pharmacologically unique sensitivity Class III antiarrhythmic agents. present study was...
EADs and DADs in M Cells. Introduction: Oscillations of membrane potential that attend or follow the cardiac action depend on preceding Tran activity for their manifestation are known as aflerdepolarizations. Early aflerdepolarizations (EADs) interrupt retard repolarization potential, whereas delayed afterdepolarizations (DADs) arise after full repolarization. can give rise to spontaneous potentials triggered believed be responsible a variety arrhythmias. Recent studies from our laboratory...
Amiodarone and ranolazine have been characterized as inactivated- activated-state blockers of cardiac sodium channel current (I(Na)), respectively, shown to cause atrial-selective depression I(Na)-related parameters. This study tests the hypothesis that their combined actions synergistically depress I(Na)-dependent parameters in atria but not ventricles.The effects acute (5 10 micromol/L) were studied coronary-perfused right atrial left ventricular wedge preparations superfused pulmonary...