A5019094411- Immune responses and vaccinations
- COVID-19 Impact on Reproduction
- Influenza Virus Research Studies
- Immune cells in cancer
- Infant Nutrition and Health
- Child Nutrition and Water Access
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Epigenetics and DNA Methylation
- Zoonotic diseases and public health
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Clinical Nutrition and Gastroenterology
- Enhanced Recovery After Surgery
- Respiratory viral infections research
McGill University Health Centre
2018-2024
McGill University
2024
Christie (Canada)
2022
Jewish General Hospital
2019
Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient 12-lipoxygenase and 15-lipoxygenase (Alox15-/- mice) neonatal neutrophil-derived 12-HETE is required for self-renewal maintenance of alveolar (AMs) during lung development. Although seeding differentiation AM progenitors remained intact, absence led to a significant reduction AMs adult lungs...
Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations response to influenza infection and their impact on disease severity remain unclear. Here, we describe, a preclinical model of mid-gestation pregnancy, mechanism enhanced host defense against A virus (IAV) localized the nasal cavity that limits viral replication reduces magnitude intrapulmonary responses. Consequently, pregnant mice show reduced pulmonary pathology preserved...
The immune system during pregnancy teeters between maintaining fetal tolerance and providing protection against pathogens. Due to this delicate balance, pregnant women their offspring often have increased susceptibilities infection. During the first year of life, infant immunity infection is mainly mediated via passively transferred maternal antibodies. However, our understanding route transfer antibodies for conferring influenza A virus (IAV) in incomplete. Here we demonstrated that from...