A5103221349- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Congenital heart defects research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hippo pathway signaling and YAP/TAZ
- Immune Response and Inflammation
- Renal and Vascular Pathologies
- Abdominal vascular conditions and treatments
- Immune Cell Function and Interaction
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Fire effects on ecosystems
- Advanced Biosensing Techniques and Applications
- Hepatitis B Virus Studies
- Urinary Tract Infections Management
- Congenital Anomalies and Fetal Surgery
- Aortic aneurysm repair treatments
- Protein purification and stability
- Vector-Borne Animal Diseases
- Peripheral Artery Disease Management
- Nosocomial Infections in ICU
- CRISPR and Genetic Engineering
Institut Pasteur
1997-2023
Inserm
1999-2023
Morphogenèse du coeur
2019-2023
Université Paris Cité
2019-2023
Délégation Paris 5
2019-2020
Institut des Maladies Génétiques Imagine
2019
Centre National de la Recherche Scientifique
2011-2015
Laboratoire de Recherche Scientifique
2010-2012
Hôpital Antoine-Béclère
1999
Institut Pasteur du Cambodge
1999
Abstract Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show mouse heart that Fat4 modulates signalling restrict mutant myocardium thicker, with increased cardiomyocyte size and proliferation, this mediated by upregulation transcriptional activity Yap1, effector pathway. not required for canonical activation kinases but it sequesters a partner...
Rift Valley fever virus (RVFV) is an enzootic circulating in Africa that transmitted to its vertebrate host by a mosquito vector and causes severe clinical manifestations humans ruminants. RVFV has tripartite genome of negative or ambisense polarity. The M segment contains five in-frame AUG codons are alternatively used for the synthesis two major structural glycoproteins, GN GC, at least accessory proteins, NSm, 14-kDa cytosolic protein, P78/NSm-GN, 78-kDa glycoprotein. To determine...
Background Rift Valley fever virus (RVFV) causes disease in livestock and humans. It can be transmitted by mosquitoes, inhalation or physical contact with the body fluids of infected animals. Severe clinical cases are characterized acute hepatitis hemorrhage, meningoencephalitis and/or retinitis. The dynamics RVFV infection cell types vivo poorly understood. Methodology/Principal Findings strains expressing humanized Renilla luciferase (hRLuc) green fluorescent protein (GFP) were generated...
Rift Valley fever (RVF) is an arthropod-borne viral disease repeatedly reported in many African countries and, more recently, Saudi Arabia and Yemen. RVF virus (RVFV) primarily infects domesticated ruminants, resulting miscarriage pregnant females death for newborns young animals. It also has the ability to infect humans, causing a feverish syndrome, meningoencephalitis, or hemorrhagic fever. The various outcomes of RVFV infection animals humans argue existence host genetic determinants...
Pseudomonas aeruginosa is an opportunistic pathogen involved in nosocomial infections. While a number of studies have demonstrated the roles TLR2, TLR4 and TLR5 host defense againt P. infection, implication TLR9 this process has been overlooked. Here, we show that DNA stimulates inflammatory response through pathway both cell line primary alveolar macrophages (AMs). This activation requires asparagine endopeptidase- endosomal acidification. Interestingly, TLR9-/- mice resisted to lethal lung...
Abstract Staphylococcus aureus is a common cause of bacterial infections in respiratory diseases. It secretes molecules to dampen host immunity, and the recently identified adenosine one these molecules. The type IIA secretory phospholipase A2 (sPLA2-IIA) protein endowed with antibacterial properties, especially against Gram-positive bacteria such as S. aureus. However, role sPLA2-IIA–mediated killing by still unknown. present studies showed that mutant lacking production (∆adsA strain)...
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) variants that have developed protease (PR) inhibitor resistance most often display cross-resistance to several molecules within this class of antiretroviral agents. The clinical benefit the switch a second PR in presence such resistant viruses may be questionable. We examined evolution HIV-1 genotypes and phenotypes individuals having failed sequential treatment with two distinct inhibitors: saquinavir (SQV) followed by indinavir (IDV). In...
Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, molecular links between cilia, IFT proteins, cardiogenesis yet to be established. Using a combination of biochemistry, genetics, live-imaging methods, we show that complex B (Ift88, Ift54, Ift20) modulate Hippo pathway effector YAP1 zebrafish mouse. We demonstrate this interaction is key restrict formation proepicardium myocardium. In cellulo...
Summary: To investigate the genetic and biologic features of HIV-1 strains circulating in Cambodia, viruses from 95 HIV-1-seropositive individuals were subtyped by heteroduplex mobility assay (HMA) 23 further analyzed for their characteristics. Eighty-nine clearly infected subtype E. The other six samples sequenced, together with 17 HMA E samples. All but one Cambodian env sequences clustered previously described Thai Vietnamese sequences, bearing a GPGQ motif at tip V3 loop; last had GPGR...
Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that both safe and effective. Development evaluation of vaccines, diagnostics treatments depend on the availability appropriate animal models. Animal models also necessary to understand basic pathobiology infection. Here, we report use an inbred MBT/Pas mouse model consistently reproduces RVF disease serves our purpose testing efficacy vaccine candidates; attenuated virus (RVFV) a recombinant RVFV-capripoxvirus....
We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed at least two clones harboring one or copies cya locus encoding major toxins, adenylate cyclase-hemolysin. No difference was observed between in murine and cellular models, probably due to high instability duplication.
Abstract Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHD). However, molecular links between cilia, IFT cardiogenesis yet to be established. Using a combination of biochemistry, genetics, live imaging methods, we show that complex B (Ift88, Ift54 Ift20) modulate Hippo pathway effector YAP1 zebrafish mouse. We demonstrate this interaction is key restrict formation proepicardium myocardium. In cellulo experiments...