A5100615153- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Cancer Cells and Metastasis
- Reproductive biology and impacts on aquatic species
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Marine Bivalve and Aquaculture Studies
- Renal and Vascular Pathologies
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Hormonal and reproductive studies
- Cancer, Stress, Anesthesia, and Immune Response
- Fish Biology and Ecology Studies
- Aquaculture Nutrition and Growth
- Sexual function and dysfunction studies
Inje University Haeundae Paik Hospital
2015-2025
Inje University Busan Paik Hospital
2013-2023
Inje University
2008-2020
University of Michigan–Ann Arbor
2017-2020
Bellingham Technical College
2020
Albany Medical Center Hospital
2019
Ann Arbor Center for Independent Living
2017
Busan Medical Center
2013-2016
Vanderbilt University Medical Center
2016
Samsung (South Korea)
2014
No AccessJournal of UrologyAdult Urology1 Oct 2013Efficacy and Safety Photodynamic Therapy for Recurrent, High Grade Nonmuscle Invasive Bladder Cancer Refractory or Intolerant to Bacille Calmette-Guérin Immunotherapy Joo Yong Lee, Richilda Red Diaz, Kang Su Cho, Meng Shi Lim, Jae Seung Chung, Won Tae Kim, Sik Ham, Young Deuk Choi LeeJoo Lee Department Urology, Yonsei University College Medicine, Seoul, Republic Korea Severance Hospital Urological Science Institute, , DiazRichilda Diaz...
Reducing the risk of urethral strictures after transurethral surgery for patients with bladder cancer requires effective strategies. We compared clinical outcomes a novel drug-injectable catheter set (NIUS) hyaluronic acid (HA) those conventional intraurethral HA injection method. This six-center, prospective, randomized, single-blind trial included 192 male aged ≥ 20 years scheduled to undergo surgery. The primary outcome was patient-reported satisfaction. Secondary were pain intensity,...
Background and Purpose: To compare the oncologic results, functional outcomes, complications of transperitoneal (TP) extraperitoneal (EP) robotic radical prostatectomy. Patients Methods: From June 2007 to April 2009, 105 patients underwent TP prostatectomy, 155 EP Clinicopathological perioperative data were compared between two groups. Postoperative outcomes including potency incontinence assessed. Results: Patient demographics similar in No significant differences positive surgical margins...
Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in function with the induction tumor metastasis. A unique aspect cancer bone metastases mouse models is their relative predilection to hindlimb (femur) compared forelimb (humerus). Comparative gene expression profiling was performed within humerus femur from non–tumor-bearing mice evaluate differences microenvironments these locations. This...
Abstract Rates of progression and treatment response in advanced prostate cancer are highly variable, necessitating non‐invasive methods to assess the molecular characteristics these tumors real time. The unique potential circulating tumor cells (CTCs) serve as a clinically useful liquid biomarker is due their ability inform via both enumeration RNA expression. A microfluidic graphene oxide‐based device (GO Chip) used isolate CTCs CTC clusters from whole blood 41 men with metastatic...
There is evidence that cancer stem-like cells (CSC) and neuroendocrine behavior play critical roles in the pathogenesis clinical course of metastatic castration-resistant prostate (m-CRPC). However, there limited mechanistic understanding how CSC phenotypes impact development m-CRPC. In this study, we explored role intracellular chemokine CXCL12γ induction differentiation its on expression was detected small-cell carcinoma tissues circulating tumor from m-CRPC patients displaying an...
Objectives To investigate the incidence of lymphocele and determine risk factors for postoperative after extraperitoneal robot‐assisted radical prostatectomy by using propensity score‐matching. Methods A total 483 patients underwent prostate cancer between J anuary 2009 ugust 2011. Of these, 200 pelvic lymph node dissection during prostatectomy. All magnetic resonance imaging or computed tomography postoperatively to detect Propensity scores an established control group were calculated each...
Objective To evaluate serial changes in renal function by investigating various clinical factors after radical nephrectomy ( RN ). Patients and Methods The study population consisted of 2068 consecutive patients who were treated at multiple institutions for cortical tumour without metastasis between 1999 2011. We measured the change estimated glomerular filtration rate eGFR ) during a 60‐month follow‐up period. over time analysed according to baseline ≥60 15–59 mL/min/1.73m 2 using linear...
The trend toward precision-based therapeutic approaches dictated by molecular alterations offers substantial promise for men with metastatic castration-resistant prostate cancer (mCRPC). However, current characterization are primarily tissue based, necessitating serial biopsies to understand changes over time and limited the challenges inherent extracting genomic material from predominantly bone metastases. Therefore, a circulating tumor cell (CTC)-based assay was developed determine gene...
While circulating tumor cell (CTC)-based detection of AR-V7 has been demonstrated to predict patient response second-generation androgen receptor therapies, the rarity expression in metastatic castrate-resistant prostate cancer (mCRPC) suggests that other drivers resistance exist. We sought use a multiplex gene platform interrogate CTCs and identify potential markers abiraterone enzalutamide. 37 patients with mCRPC initiating treatment enzalutamide (n = 16) or 21) were prospectively enrolled...
To evaluate the subclassifications of pT2 diseases in tumour-nodes-metastases (TNM) staging system for prostate cancer.We retrospectively analysed data 372 patients who underwent radical retropubic prostatectomy (RRP) pathologically organ-confined cancer at our institution. Pathological all subjects were re-evaluated using 1997 and 2002 TNM cancer. Various clinicopathological features along with biochemical recurrence-free survival (BRFS) subgroups assessed.Using criteria, 87 tumours (23.4%)...
Prostate-specific antigen (PSA) is used for diagnosing prostate cancer, but does not reflect the characteristics of cancer cells to allow assessment progression. PSA mRNA and circulating tumor (CTCs) could be potential biomarkers. However, relationship between serum levels in CTCs unclear, this study aimed investigate relationship.Healthy donors (HD, n = 9), patients with local non-metastatic stage (n 30), metastatic hormone-sensitive (mHSPC, 10), castration-resistant (mCRPC, 75), were...
Circulating tumor cells (CTCs) display antigenic heterogeneity between epithelial and mesenchymal phenotypes. However, most current CTC isolation methods rely on EpCAM (epithelial cell adhesion molecule) antibodies. This study introduces a more efficient technique utilizing both vimentin (mesenchymal marker) antibodies, alongside lateral magnetophoretic microseparator. The effectiveness of this approach was assessed by isolating CTCs from prostate (n = 17) pancreatic 5) cancer patients using...
We compared the preventive effects of cyclosporine A combined with prednisolone and melatonin (Sigma-Aldrich) on damage to contralateral testis after ipsilateral testicular torsion-detorsion between pubertal adult rats.We divided Sprague-Dawley rats into groups 1-sham operation, 2-detorsion, 3-detorsion plus 4-detorsion melatonin. After 4 hours torsion we treated detorsion only or drug depending group.Seminiferous tubule diameter germ cell layer thickness were greater in group 3 than at each...
We report a case of synchronous rectal and prostate cancer treated successfully with simultaneous da Vinci robotic-assisted low anterior resection the rectum laparoscopic radical prostatectomy to address both cancers.Recently, minimally invasive surgical techniques using robot® system (Intuitive Surgical, Sunnyvale, USA) were introduced as curative modality malignancies. Herein, we an initial robotic for adenocarcinoma sharing considerable number port sites.Simultaneous could be performed...
Cardiovascular events (CVE) are the leading cause of mortality in kidney transplant recipients. The adverse effects long-term therapy with steroids on cardiovascular risk have motivated increasing interest steroid withdrawal (SW). objective this study was to compare incidences CVE and all-cause between patients who had undergone SW at 1 year posttransplant control continued steroids.A cohort 400 consecutive adult recipients a 1993 1998 qualified for late studied. At 188 underwent SW, whereas...
A Multiinstitutional Clinicopathologic StudyWe developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and determine when neurovascular bundle (NVB) may be spared.Total 1,471 Korean men who underwent radical prostatectomy for between 1995 2008 were included.We drew nonrandom samples 1,031 development, leaving 440 validation.With multivariate logistic regression analyses, we made predicts ECE at prostatectomy.Receiver operating...
Abstract We aimed to isolate circulating tumor cells (CTCs) using a microfluidic technique with novel lateral magnetophoretic microseparator. Prostate cancer–specific gene expressions were evaluated mRNA from the isolated CTCs. A CTC‐based multigene model was then developed for identifying advanced prostate cancer. Peripheral blood samples obtained five healthy donors and patients localized cancer (26 cases), metastatic hormone‐sensitive (mHSPC, 10 castration‐resistant (mCRPC, 28 cases). CTC...